Thoracoscopic radical esophagectomy and laparoscopic transhiatal lymph node dissection for superficial esophageal cancer associated with lymph node metastases in the dorsal area of the thoracic aorta
© Ninomiya et al.; licensee Springer. 2015
Received: 12 December 2014
Accepted: 18 February 2015
Published: 10 March 2015
Esophageal cancer invading the muscularis mucosa sometimes involves regional lymph node metastases. However, lymph node metastases are rare in the dorsal area of the thoracic aorta. We describe a patient with an intramucosal esophageal cancer invading the muscularis mucosa, accompanied by lymph node metastases in the dorsal area of the thoracic aorta. These lesions were successfully resected by hand-assisted laparoscopic surgery using a transhiatal approach. A 60-year-old man was diagnosed with superficial esophageal cancer during a routine health examination. Endoscopic examination and ultrasonography revealed a superficial cancer, of diameter 6.0 cm, invading the submucosal layer and intramural metastases caudal to the primary tumor. Enhanced computed tomography and F-deoxyglucose positron emission tomography demonstrated the two metastatic lymph nodes, one in the dorsal area of the thoracic aorta and the other near the left gastric artery. Thoracoscopic radical esophagectomy with three-field lymph node dissection was performed. The metastatic lymph node in the dorsal area of the thoracic aorta was successfully removed by hand-assisted laparoscopic surgery using a transhiatal approach. Histopathological examination showed primary cancer invading the muscularis mucosa and intramural metastases in the lamina propria mucosa and submucosal layer. The pathological diagnosis according to the Japanese classification of esophageal cancer was MtLt, 47 mm, 0-IIa + IIb, pT1a-MM, ie(+), INF-b, ly3, v0, pN4(4a), pIM1, M0, and pstage IVa. The patient underwent two courses of adjuvant chemotherapy, consisting of CDDP and 5-fluorouracil. At present, 1 year and 8 months after surgery, the patient remains alive without tumor recurrence. Although the lymph node in the dorsal area of the thoracic aorta is not recognized as regional nodes of thoracic esophageal cancer, solitary mediastinal metastases from a mucosal cancer may indicate the existence of direct lymphatic flow from the thoracic esophagus to the retroaortic region. Transhiatal approach by hand-assisted laparoscopic surgery is useful to dissect the metastatic lymph node in the dorsal area of the thoracic aorta.
KeywordsEsophageal cancer Lymphatic metastasis Video-assisted surgery Thoracic-aorta
Superficial esophageal cancer invading the muscularis mucosa (MM) may occasionally be associated with lymph node metastases [1,2]. In the Japanese classification of esophageal cancer, regional lymph nodes have been classified by their associations with patient prognosis, based on their rates of metastasis and patient survival [3,4]. Lymph node metastases are rare in the dorsal area of the thoracic aorta. Therefore, the lymph node in the dorsal area of the thoracic aorta is not recognized as regional nodes. We describe a patient with an intramucosal esophageal cancer invading the MM, accompanied by lymph node metastases in the dorsal area of the thoracic aorta. These lesions were successfully resected by hand-assisted laparoscopic surgery (HALS) using a transhiatal approach.
The esophagus has multidirectional lymphatic flow, resulting in widespread and random patterns of lymph node metastasis from the cervical to the abdominal areas. Lymphatics form a dense submucosal plexus running longitudinally and non-segmentally, resulting in metastases to distant regional lymph nodes. The rate of metastasis and the importance of dissection of regional lymph nodes in patients with thoracic esophageal cancer were previously investigated in a large number of patients who underwent radical esophagectomy . However, none of these patients had metastases in the retroaortic area. Recurrence after radical esophagectomy has been reported in the distant viscera, the locoregional area, and at multiple sites . A report described two patients with solitary nodal recurrence in the dorsal area of the thoracic aorta after curative resection of esophageal cancer . This area is therefore a site of tumor recurrence after curative surgery operation. In contrast, only two case reports have described primary esophageal cancer associated with lymph node metastases in the dorsal area of the thoracic aorta [10,11]. Horio et al.  speculated that metastases in the dorsal area of the thoracic aorta may indicate nearby extensive lymph-node metastasis, even if the metastasis appears solitary on preoperative examination. In our institution, lymphatic recurrence after radical thoracoscopic esophagectomy was observed in 23 of 146 (15.8%) patients. Nodal recurrence in the mediastinal area is infrequent after radical thoracoscopic esophagectomy . However, six (4.1%) patients showed lymphatic recurrence in the dorsal area of the thoracic aorta. Among these six patients, three patients survived after local therapy by radiation or surgical resection. Therefore, we convinced surgical resection to the lymph node metastasis in the dorsal area of the thoracic aorta might have a certain degree of survival benefit in some cases.
Previous studies showed 1% to 8.5% of mucosal esophageal squamous cell carcinoma showed lymph node metastasis [12-15]. Multicenter retrospective cohort study showed only two patients (1.9%) among 104 patients with 111 lesions of esophageal squamous cell cancer invading the MM developed lymph node metastasis after endoscopic mucosal resection . However, lymph node metastasis was observed in 18.0% in patients with esophageal squamous cell cancer invading the MM who underwent radical esophagectomy with lymph node dissection . Lymphatic permeation has been reported to be a good predictor of lymph node metastasis in patients with superficial esophageal cancer . As far as we know, there have been no reports of the mucosal esophageal squamous cell cancer accompanied by distant lymph node metastasis. The primary tumor in our patient had highly aggressive metastatic potential, as indicated by lymphatic invasion of the primary tumor, the intramural metastasis, and lymph node metastases in two separate areas, the distant mediastinal and abdominal regions. However, the primary tumor was a mucosal cancer invading the MM layer, with only one metastatic lymph node in the mediastinum. Solitary mediastinal metastases from a mucosal cancer may indicate the existence of direct lymphatic flow from the thoracic esophagus to the retroaortic region.
Previously, lymph node metastases in the dorsal area of the thoracic aorta were removed using a transthoracic approach from the left thoracic cavity [10,11]. To remove all the regional lymph nodes as well as the metastatic retroaortic lymph node by transthoracic approach, a bilateral transthoracic procedure is needed in this case. We used a transhiatal approach to dissect the lymph node in the dorsal area of the thoracic aorta of our patient. The use of pneumomediastinum and anterior retraction of the thoracic aorta made visualization of the retroaortic area possible. In performing transhiatal approach for mediastinal dissection, counter retraction to enlarge the esophageal hiatus is necessary. We created four ports to insert the retractors, an Enseal device (Ethicon Endo-Surgery, Inc., Ohio, USA) and a scope in HALS procedure.
We could safely dissect the metastatic lymph node using an EnSeal device and complete curative dissection without using a left transthoracic approach, thus minimizing surgical trauma.
In conclusion, the lymph nodes in the dorsal area of the thoracic aorta may be metastatic sites in patients with thoracic esophageal cancer. A laparoscopic transhiatal approach may be useful in dissecting lymph nodes in the dorsal area of the thoracic aorta in circumstances where lymph node metastasis in this area is suspected.
Written informed consent was obtained from the patient for publication of this Case report and any accompanying images.
- Shimizu Y, Tsukagoshi H, Fujita M, Hosokawa M, Kato M, Asaka M. Long-term outcome after endoscopic mucosal resection in patients with esophageal squamous cell carcinoma invading the muscularis mucosae or deeper. Gastrointest Endosc. 2002;56(3):387–90.View ArticlePubMedGoogle Scholar
- Katada C, Muto M, Momma K, Arima M, Tajiri H, Kanamaru C, et al. Clinical outcome after endoscopic mucosal resection for esophageal squamous cell carcinoma invading the muscularis mucosae - a multicenter retrospective cohort study. Endoscopy. 2007;39(9):779–83.View ArticlePubMedGoogle Scholar
- Japan Esophageal Society. Japanese classification of esophageal cancer, tenth edition: part I. Esophagus. 2009;6(1):1–25.View ArticleGoogle Scholar
- Japan Esophageal Society. Japanese classification of esophageal cancer, tenth edition: parts II and III. Esophagus. 2009;6(2):71–94.View ArticleGoogle Scholar
- Ninomiya I, Okamoto K, Fujimura T, Fushida S, Osugi H, Ohta T. Oncologic outcomes of thoracoscopic esophagectomy with extended lymph node dissection: 10-year experience from a single center. World J Surg. 2014;38(1):120–30.View ArticlePubMedGoogle Scholar
- Shiozaki A, Fujiwara H, Murayama Y, Komatsu S, Kuriu Y, Ikoma H, et al. Posterior mediastinal lymph node dissection using the pneumomediastinum method for esophageal cancer. Esophagus. 2012;9:58–64.View ArticleGoogle Scholar
- Udagawa H, Ueno M, Shinohara H, Haruta S, Kaida S, Nakagawa M, et al. The importance of grouping of lymph node stations and rationale of three-field lymphoadenectomy for thoracic esophageal cancer. J Surg Oncol. 2012;106(6):742–7.View ArticlePubMedGoogle Scholar
- Bhansali MS, Fujita H, Kakegawa T, Yamana H, Ono T, Hikita S, et al. Pattern of recurrence after extended radical esophagectomy with three-field lymph node dissection for squamous cell carcinoma in the thoracic esophagus. World J Surg. 1997;21(3):275–81.View ArticlePubMedGoogle Scholar
- Kaisaki S, Kitayama J, Ishigami H, Nagawa H. Solitary nodal recurrence in the dorsal area of the thoracic aorta after a curative resection of esophageal cancer: report of two cases. Surg Today. 2007;37(3):243–7.View ArticlePubMedGoogle Scholar
- Horio T, Ogata S, Tsujimoto H, Akase T, Takahata R, Yaguchi Y, et al. Esophageal cancer initially thought to be accompanied by a solitary metastasis to an intrathoracic paraaortic lymph node. Acta Med Okayama. 2012;66(5):417–21.PubMedGoogle Scholar
- Preston SR, Baker CR, Priest OH, Sudderick RM. Thoracoscopic-assisted four-phase esophagectomy with four-field lymph node dissection for esophageal cancer: case report and description of a new technique. J Laparoendosc Adv Surg Tech A. 2012;22(7):701–4.View ArticlePubMedGoogle Scholar
- Fujita H, Sueyoshi S, Yamana H, Shinozaki K, Toh U, Tanaka Y, et al. Optimum treatment strategy for superficial esophageal cancer: endoscopic mucosal resection versus radical esophagectomy. World J Surg. 2001;25(4):424–31.View ArticlePubMedGoogle Scholar
- Tachibana M, Hirahara N, Kinugasa S, Yoshimura H. Clinicopathologic features of superficial esophageal cancer: results of consecutive 100 patients. Ann Surg Oncol. 2008;15(1):104–16.View ArticlePubMedGoogle Scholar
- Li B, Chen H, Xiang J, Zhang Y, Kong Y, Garfield DH, et al. Prevalence of lymph node metastases in superficial esophageal squamous cell carcinoma. J Thorac Cardiovasc Surg. 2013;146(5):1198–203.View ArticlePubMedGoogle Scholar
- Tanaka T, Matono S, Mori N, Shirouzu K, Fujita H. T1 squamous cell carcinoma of the esophagus: long-term outcomes and prognostic factors after esophagectomy. Ann Surg Oncol. 2014;21(3):932–8.View ArticlePubMedGoogle Scholar
- Eguchi T, Nakanishi Y, Shimoda T, Iwasaki M, Igaki H, Tachimori Y, et al. Histopathological criteria for additional treatment after endoscopic mucosal resection for esophageal cancer: analysis of 464 surgically resected cases. Mod Pathol. 2006;19(3):475–80.View ArticlePubMedGoogle Scholar
- Tajima Y, Nakanishi Y, Ochiai A, Tachimori Y, Kato H, Watanabe H, et al. Histopathologic findings predicting lymph node metastasis and prognosis of patients with superficial esophageal carcinoma: analysis of 240 surgically resected tumors. Cancer. 2000;88(6):1285–93.View ArticlePubMedGoogle Scholar
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