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Typical carcinoid in right middle lobe of pulmonary hypoplasia
Surgical Case Reports volume 9, Article number: 135 (2023)
Abstract
Background
Pulmonary typical carcinoid occurring in hypoplasia of the right middle lobe is very rare.
Case presentation
A routine examination's chest X-ray revealed an abnormal shadow in the right middle lung field of an 82-year-old Japanese woman. A chest computed tomography scan showed a solid 2.5 × 2.0-cm nodule in the very small right middle lobe. A trans-bronchial lung biopsy of the mass in the right middle lobe was performed; it revealed atypical cells with round nuclei growing in multiple foci, and immunostaining was positive for chromogranin A, synaptophysin and CD56, suggesting pulmonary carcinoid. The preoperative clinical diagnosis of primary lung cancer, cT1cN0M0 stage IA3 was considered. A right middle lobectomy and mediastinal lymph node dissection were performed by video-assisted thoracic surgery. Intraoperatively, the middle lobe of the right lung was very small, with 1- to 2-mm-dia. pulmonary arteries and veins that were considered hypoplastic. The final histopathological diagnosis was typical carcinoid, pT2aN0M0 stage IB based on the presence of pleural invasion.
Conclusions
Including the present patient, only nine cases of lung cancer occurring within pulmonary hypoplasia have been reported, most of which were typical carcinoid.
Case presentation
A routine examination's chest X-ray revealed an abnormal shadow in the right middle lung field of a never-smoker, 82-year-old Japanese woman. She had a medical history of atrial fibrillation and stomach ulcer. A chest computed tomography (CT) scan showed a solid 2.5 × 2.0-cm nodule in the very small right middle lobe (Fig. 1). Positron emission tomography (PET) showed an accumulation of 18F-fluorodeoxyglucose (FDG) in the nodule, with a maximum standardized uptake value (SUVmax) of 3.68 in the early phase and 5.63 in the late phase. Bronchoscopy showed patency of B4 and B5 up to subsegmental bronchi and no abnormal bifurcation (Fig. 2a).
A trans-bronchial lung biopsy (TBLB) of the mass in the right middle lobe was performed; it revealed atypical cells with round nuclei growing in multiple foci, and immunostaining was positive for chromogranin A, synaptophysin and CD56, suggesting pulmonary carcinoid. The preoperative clinical diagnosis of primary lung cancer, cT1cN0M0 stage IA3 was considered.
A right middle lobectomy and mediastinal lymph node dissection were performed by video-assisted thoracic surgery (Fig. 2b). Intraoperatively, the middle lobe of the right lung was very small, and both the pulmonary arteries and veins were 1–2 mm in diameter, which was considered pulmonary hypoplasia. The size of the resected right middle lobe was 5.3 × 3.0 × 2.8 cm, and the tumor was 2.8 × 1.3 × 1.1 cm (Fig. 3a).
The histopathological examination showed that the tumor was composed of a proliferation of atypical cells with round or oval nuclei and stippled chromatin. Pleural invasion of tumor cells was observed. There was no mitosis or necrosis (Fig. 3b). The immunohistochemical analysis revealed positivity for chromogranin A, synaptophysin, and CD56 (Fig. 4). The normal area of the resected lung did not show the inflammatory cell infiltration usually seen in atelectatic lung, so we consider it to be lung hypoplasia rather than atrophic lung caused by atelectasis. The final histopathological diagnosis was typical carcinoid, pT2aN0M0 stage IB. Because of the patient's advanced age, she was followed up without adjuvant chemotherapy and has survived for 5 years without recurrence.
Discussion
Regarding the frequency of pulmonary dysplasia including hypoplasia, Krivchenya et al. [1] reported pulmonary dysplasia including hypoplasia in 0.01–0.067% of their series of autopsy cases, and Conway et al. [2] reported the rate 0.001% of delivery cases. This disorder rarely remains asymptomatic into adulthood, due to the presence of severe respiratory complications and/or congenital heart disease and gastrointestinal, genitourinary, and skeletal abnormalities in 50–85% of cases of pulmonary dysplasia including hypoplasia [3, 4]. Pulmonary dysplasia can be classified into three categories: aplasia, in which lung parenchyma, bronchi, and pulmonary vessels are absent; dysplasia, in which traces of bronchi are present but lung tissue and pulmonary vessels are absent; and hypoplasia, in which lung parenchyma, bronchi, and vessels are present but the number of alveoli is reduced and the airways and vessels are immature [1]. In the present case, there was no luminal narrowing or obstruction in the right middle lobe bronchus, and the presence of immature lung parenchyma and vessels suggested hypoplasia.
The cases of nine patients with lung cancer within pulmonary hypoplasia [5,6,7,8,9] including our present patient have been reported (Table 1). Interestingly, all cases were neuroendocrine tumors of right middle lobe origin, and eight of the nine cases were typical carcinoid tumors. Moreover, all of these cases were reported from Japan. Although there are reports of unknown prognosis and short observation periods, none of them have reported recurrence, and the prognosis appears to be good. Yukawa et al. speculated that neuroendocrine cells are activated to compensate for tissue remodeling in the hypoplastic lung, resulting in neuroendocrine hyperplasia, which may lead to carcinoid-precursor lesion development [9]. Motono et al. noted that if lung hypoplasia causes reactive neuroendocrine hyperplasia, then neuroendocrine tumors may occur with lung hypoplasia [8]. Although there are few reports of lung cancers developing in pulmonary hypoplasia, most of the cases are typical carcinoid, suggesting that there is some association between lung hypoplasia and carcinoid. To elucidate this, it may be necessary to pathologically clarify the state of neuroendocrine cells in the bronchial epithelium of the pulmonary hypoplasia.
There are several surgical problems in cases of lung cancer with pulmonary hypoplasia. Because pulmonary hypoplasia is occasionally associated with abnormal bronchial and vascular structures, it is necessary to observe the bronchial lumen by bronchoscopy and to fully confirm the pulmonary arteriovenous branches by CT scanning before surgery. In addition, as in the present case, the pulmonary arteries and veins are very thin in hypoplastic lungs, and careful manipulation is necessary to avoid extraction injury. The lung parenchyma is very small in hypoplastic lungs, making it difficult to avoid touching the tumor. Lung cancer occurring in pulmonary hypoplasia is a concern because the volume of lung parenchyma is small relative to the size of the tumor, making it more likely to invasive surround tissues. However, no invasion into surrounding tissues has been reported to date, which may be related to the fact that the tumor is a typical carcinoid with good prognosis and a central bronchogenic origin.
Conclusions
We have described a case of typical carcinoid developing in right middle lobe hypoplasia. Since previous reports suggest an associated between pulmonary hypoplasia and typical carcinoid, it will be necessary to accumulate more cases to elucidate the association.
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Abbreviations
- CT:
-
Computed tomography
- PET:
-
Positron emission tomography
- FDG:
-
Fluorodeoxyglucose
- SUV:
-
Standardized uptake value
- TBLB:
-
Trans-bronchial lung biopsy
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YK administered the clinical treatments. YK drafted the manuscript. TH and HN performed a dedicated review and contributed to the discussion. TM, SM, and TO helped make the pathological diagnosis. All authors read and approved the final manuscript.
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Kubouchi, Y., Kojima, S., Fujiwara, W. et al. Typical carcinoid in right middle lobe of pulmonary hypoplasia. surg case rep 9, 135 (2023). https://doi.org/10.1186/s40792-023-01718-4
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DOI: https://doi.org/10.1186/s40792-023-01718-4