Congenital hemophilia A is an X-linked recessive coagulation disorder caused by factor VIII deficiency. This disorder is characterized by a bleeding tendency, a normal PT, and a prolonged aPTT. As the most common congenital coagulopathy, hemophilia A occurs in 1–2 per 10,000 male births . In severe hemophilia, deep bleeding such as intra-articular and intramuscular hemorrhage is seen in infancy and early childhood due to increased mobility and activity. Unusual purpura or hematoma may also trigger the diagnosis . In this case, hemophilia was not diagnosed preoperatively because the patient showed no symptoms of blood disorder. In hemophilia, the PT and platelet count remain normal and the aPTT is prolonged. Patients with mild hemophilia may have a normal aPTT. If the aPTT is prolonged, mixing studies can determine whether the patient has a factor deficiency or presence of an inhibitor. Factor activity levels are measured for the relevant factor if a familial defect is known, or for all of these factors in new cases. The diagnosis of hemophilia A requires confirmation of a factor VIII activity level below 40% of normal or, in some circumstances where the factor VIII activity level is ≥ 40%, a pathogenic factor VIII gene mutation. A normal vWF antigen should also be documented to eliminate the possibility of some forms of von Willebrand disease. In this case, factor VIII activity level of the patient was 34% and a normal level of vWF antigen, so hemophilia A was diagnosed. Patients with hemophilia A need regular replacement therapy or on-demand replacement therapy (i.e., factor given only in the setting of acute bleeding or surgery). Regular replacement therapy is expensive and places substantial burdens on the patient for recurrent venous access, but patients with mild pathology can receive on-demand therapy only. The "Guidelines for Hemostatic Treatment of Hemophilia Patients without Inhibitors" by The Japanese Society on Thrombosis and Hemostasis recommend that patients undergoing surgery under general anesthesia should be administered a trough factor level of at least 80% for 5–10 days, and thereafter a trough factor level of at least 30% for 3–5 days .
Postoperative hemorrhage in thyroid surgery can cause laryngeal edema, which can lead to asphyxia. In the case of postoperative bleeding, emergency reoperation to evacuate hematoma is mandatory. In our case, reoperation was performed immediately after the bleeding was detected. However, some points of difference from the usual progress of postoperative bleeding were apparent. First, the onset of postoperative bleeding was slower than usual. One report found that 95.7% of postoperative bleeding occurs within 24 h after surgery , but our patient experienced bleeding after 27 h. Second, no arteriovenous vessels were detected as bleeding points. In general, postoperative hemorrhage from thyroid surgery occurs in 1–1.5% . According to a previous report , 67% of bleeding points are arterial, 27% are venous, and 6% show no specific bleeding source, but display diffuse oozing. Abnormal coagulation was thought to have resulted in very mild venous hemorrhage, which would normally be expected to stop spontaneously, and physical movement may have triggered further bleeding, resulting in neck swelling. Third, the drain insertion site is usually covered with blood clots or plasma, but this case showed fresh blood without coagulation when we removed the drain 2 days after reoperation, and the amount of blood collected in the drain bag was only 22 mL. Fourth, subcutaneous hematoma was observed again on POD 11, 5 days after discharge from hospital, despite the patient being discharged after sufficient wound compression and confirmation of resolution of swelling. At this point, we considered the possibility of non-surgical causes of bleeding. Thorough examination then revealed abnormalities in blood coagulability. Because the cause of bleeding had been unclear and a risk of rebleeding was suggested, we had recommended continued hospitalization and observation, but the patient wanted to return home early. Since the pace of bleeding was slow, we had discharged the patient on the premise that we would contact him if any bleeding tendency was identified, but the bleeding recurred 5 days after discharge. The amount of bleeding at this time was about 5 mL, and since no subjective symptoms such as breathing discomfort were present and the bleeding rate was very slow, we judged the possibility of airway symptoms as low. Pressure was applied to the wound with gauze and outpatient follow-up was continued, with the wound absorbed spontaneously. Since then, the patient has not experienced any further neck bleeding.
In this case, no family or medical history was suggestive of hematological disease. Preoperative blood tests were not predictive of abnormalities in coagulation capacity. However, careful elicitation of history during the postoperative interview identified episodes of bleeding difficulty during a previous tooth extraction. If those bleeding episodes had been confirmed, the diagnosis of hemophilia could have been made earlier. Asking patients about previous bleeding episodes preoperatively is recommended, in addition to checking the medical history and blood test results.