Solitary fibrous tumor of the greater omentum: case report and review of literature

Abstract

Background

Solitary fibrous tumor (SFT) is a rare neoplasm of mesenchymal origin occurring most often in the visceral pleura, however, it has been described in almost every anatomic location of the human body. While most SFTs have a benign behavior, they can potentially be locally aggressive and demonstrate a malignant behavior.

Case presentation

A 63 year-old male patient presented with lower abdominal pain and nausea and was noted on CT to have a large, heterogeneous lower abdominal mass with no evidence of metastatic disease. A surgical resection was performed and the mass appeared to be connected to the greater omentum with a vascular pedicle. It was not invading any intra-abdominal or pelvic organs. Pathology revealed an SFT of omental origin. The mitotic count was less than 4 per 10 high-power fields and all pathologic characteristics did not meet the criteria for a malignant SFT.

Conclusions

We report an extremely rare case of SFT originating from the greater omentum. A multidisciplinary team approach was followed to plan the patient’s management strategy.

Background

Solitary fibrous tumor (SFT) is a rare soft tissue tumor of mesenchymal origin that accounts for less than 2% of all soft tissue masses [1]. It was first described in the pleura in 1931 [2] and approximately 30% of SFTs arise in the thoracic cavity (pleura, mediastinum, lung parenchyma), while extra pleural tumors arise in the peritoneal cavity, retroperitoneal and pelvic soft tissue, abdominal viscera, deep soft tissue of extremities and head and neck [3]. The abdominal cavity represents the most frequent extra pleural site for SFTs; nevertheless, these tumors are much less common in the peritoneal than in the pleural cavity [4]. SFT involving the omentum have been previously reported in the literature. Herein, we report a rare case of a large SFT originating from the greater omentum and review the literature on the subject.

Case presentation

A 63 year-old gentleman presented to the emergency department with non-specific periumbilical pain and nausea. He denied any vomiting, changes to his bowel habits, weight loss, fever or history of similar pain episodes. He was otherwise healthy and had no previous abdominal surgeries. On physical examination, there was some mild lower abdominal tenderness, but no mass was clinically palpable. A computed tomography (CT) of the abdomen and pelvis with oral and intravenous contrast was done and revealed a heterogeneous appearing mass like lesion in the midline of the pelvis measuring 11.4 × 6.8 × 6.6 cm. It showed peripheral enhancement with central hypodensity. The mass appears to be intimately associated with multiple segments of small bowel in the lower abdomen with no associated bowel obstruction (Fig. 1). The initial radiologist impression was suggestive of a possible gastrointestinal stromal tumor. A CT scan of the chest was performed as well and there was no evidence of metastatic disease in the abdominal or thoracic cavities.

Fig. 1

Heterogeneous SFT mass in the midline of the pelvis measuring 11.4 × 6.8 × 6.6 cm

The case was discussed in multidisciplinary tumor boards and the consensus was to proceed with surgical resection of the primary tumor. The patient was therefore taken to the operating room for a diagnostic laparoscopy, laparotomy and resection of the mass which was not found to involve the small bowel. During laparoscopic exploration, we did not identify any liver metastases or peritoneal deposits. The mass was occupying the middle portion of the lower abdominal cavity. We elected to convert to an open procedure due to concerns of disrupting the integrity of the tumor during laparoscopic dissection given its large size and weight. It was connected to the greater omentum with a vascular pedicle and slightly adherent to epiploic appendages of the sigmoid colon. An intraoperative flexible sigmoidoscopy was performed and was unremarkable. The mass was not invading any intra-abdominal structures and there was no evidence of metastatic disease. It was resected en bloc with adequate margin on the omental pedicle. The patient had an uneventful recovery and was discharged home on postoperative day three.

Pathology revealed an SFT arising from the omentum. It was described as a finely encapsulated bosselated mass with a rubbery texture and weighed 225 g (Fig. 2). Microscopic examination showed a cellular lesion that was not invading the thin capsule with areas of necrosis, which likely represents infarction with a focal histiocytic reaction. The lesion was composed of plump spindled or slightly epithelioid cells in a small, storiform pattern. Nuclei appeared mildly atypical and relatively monomorphic. The mitotic count was less than 4 per 10 high-power fields and no abnormal mitoses were seen, so the lesion did not meet the criteria for a malignant SFT. However, given the fact that mitoses are not rare, it was best considered of unknown biological potential. The lesion was relatively vascular with abundant capillaries and background larger, thin-walled vessels (Fig. 3). The pedicle was identified arising from the omentum and showed no evidence of tumor invasion. Immune histochemical staining demonstrated the tumor cells are negative from CD31, ASMA, S100, AE1/AE3, calretinin, desmin and CD117. The tumor was positive for vimentin, BCL-2 and CD34 (Fig. 4). CD31 develops the vessels in the background. The very rare tumor cell was positive for epithelial membrane antigen (EMA).

Fig. 2

Tumor after complete surgical resection, encapsulated bosselated mass

Fig. 3

Hematoxylin and eosin-stained sections: a, b thin-walled vessels with staghorn-like appearance (+ 100 magnification power), c areas of necrosis (+ 100 magnification power), d spindle cells and collagen deposits (+ 200 magnification power)

Fig. 4

Immunohistochemical test (+ 100 magnification power): immunohistochemical test showing the tumor was positive for CD34 (a), and bcl-2 (b), and negative for CD31 (c)

Given the benign nature of the tumor histopathology and the completeness of the resection with negative margins, adjuvant chemo- or radiation therapy was deemed not indicated in multidisciplinary discussions. At 6 months follow-up, the patient remains asymptomatic with no clinical or radiologic evidence of recurrence or metastatic disease. The team agreed that routine surveillance may not be required and imaging and other investigations could be done as needed if the patient develops concerning symptoms or signs on examination.

Discussion

SFTs are rare soft tissue neoplasms of mesenchymal origin occurring most often in the visceral pleura; nevertheless, they have been described in different anatomic locations [3]. They most commonly present in the fifth and sixth decade of life and appear to be equally distributed between men and women [5, 6]. Between 50 and 80% of thoracic SFT are asymptomatic masses while symptomatic tumors usually present with non-specific chest complaints such as chest pain, cough or dyspnea [7]. The abdominal cavity is the second most common location of SFT which has been noted in intraperitoneal, retroperitoneal and pelvic locations. Similar to intrathoracic SFT, they are generally asymptomatic until they reach a large enough size to cause mass effect on the intra-abdominal viscera [1, 8]. Non-specific abdominal symptoms include pain, vomiting and urinary symptoms. Uncommonly, patients may present with paraneoplastic syndrome, most commonly non-islet cell hypoglycemia. Paraneoplastic syndromes may occur in patients with SFT arising in all sites [9].

A definitive diagnosis of SFT requires histologic confirmation. Because many have non-specific symptoms or are asymptomatic, they are often identified incidentally on imaging studies [10]. On computed tomography (CT) and magnetic resonance imaging (MRI), they usually appear as well-circumscribed hypervascular lobulated soft tissue masses with areas of hemorrhage and necrosis particularly in large tumors [5].

Conventional immunohistochemical (IHC) markers of SFT include CD34, Bcl2, CD99, and vimentin in the absence of actin, desmin, S100 protein, or EMA. Nevertheless, these markers are not specific for SFT and may be inconsistently expressed [11, 12]. More recently, a strong nuclear expression of the C-terminal part of STAT6 (signal transducer and activator of transcription 6) has been shown to be a highly sensitive and specific marker for SFT, with a sensitivity and specificity of 98% and greater than 85%, respectively. However, STAT6 positivity alone may not be sufficient to distinguish some cases of SFT from its histologic mimic well-differentiated/dedifferentiated liposarcoma [8, 13, 14].

The management of SFT should be discussed in multidisciplinary tumor boards and a complete en bloc surgical resection represents the mainstay of therapy for all localized tumors [15]. Obtaining adequate negative margins has been shown to decrease the rate of local recurrence and improve overall survival [16]. In cases with positive surgical margins, particularly in higher-grade SFT, surgical re-resection should be considered [17]. The use of radiation therapy is best decided on a case-by-case basis in the context of a multidisciplinary discussion. For resected SFT with certain higher risk features such as positive surgical margins or high mitotic count, the use of adjuvant radiation may prevent local recurrences; however, an overall survival benefit has not been established [18, 19]. The role of adjuvant chemotherapy for resected SFT is unknown and the effectiveness of standard cytotoxic chemotherapeutic agents remains relatively poor [10]. Given the lack of data and the low incidence of SFTs, the benefit of adjuvant radiation and chemotherapy remains unknown. Additional clinical studies are needed to better characterize the molecular pathways involved with SFT in order to treat it more effectively.

The majority of SFTs have a benign behavior and do not recur locally or distally; nevertheless, 10–25% of pleural SFTs recur at 10 years [20,21,22,23]. Factors associated with poor prognosis include recurrent tumors, macro- or microscopically positive resection margins, tumor size > 10 cm, the presence of > 4 mitoses/10 HPF, increased nuclear pleomorphism, increased cellularity and presence of malignant component [1]. Solitary fibrous tumors originating from the greater omentum are extremely rare. To the best of our knowledge, only 15 [24,25,26,27,28,29,30,31,32,33,34,35,36,37,38] cases have reported in the literature up till December 2020 (Table 1).

Table 1 Reported cases of greater omentum SFT in the literature

Conclusions

We presented a case of SFT of the greater omentum that was discovered on a CT done to investigate vague abdominal symptoms. Surgical resection was performed with negative margins and the tumor did not meet the criteria of malignant SFTs, therefore the patient did not receive adjuvant therapy. A multidisciplinary team approach was followed to plan the management along its course of progression.