Isolated myeloid sarcoma presenting with small bowel obstruction: a case report

Background

Myeloid sarcoma (MS) is a solid tumor consisting of myeloid blasts or immature myeloid cells, which are unusual outside the bone marrow.

Case presentation

We present a rare case of isolated myeloid sarcoma of the small bowel in a 54-year-old man who was admitted to our hospital with repeated symptoms of intestinal obstruction. A small bowel series via an ileus tube revealed severe jejunal obstruction. Computed tomography revealed that the obstruction was likely caused by a jejunal tumor. The patient underwent laparoscopy-assisted partial resection of the jejunum with lymphadenectomy. Histopathological examination of the surgical specimen confirmed that MS had been responsible for the obstruction.

Conclusions

Patients with MS require systemic chemotherapy, as do patients with acute myeloid leukemia. Hence, an early, accurate diagnosis is imperative for treating this malignancy. It is also important to list MS in the differential diagnosis of a small bowel tumor, even in nonleukemic patients.

Myeloid sarcoma (MS), a solid tumor consisting of myeloid blasts or immature myeloid cells outside the bone marrow, is an unusual presentation of acute myeloid leukemia (AML). MS is also known by other names—e.g., chloroma, granulocytic sarcoma—which can create some confusion in understanding this disease. MS can develop anywhere in the body, with the most common sites being the lymph nodes, bone/spine, and skin. Development of MS in the small intestine is reported to account for 10–11% of all MSs occurring in the gastrointestinal tract [1]. Because of its rarity and difficult diagnosis, MS has often been misdiagnosed as other diseases [2]. Here, we report a rare case of isolated primary MS of the small bowel causing intestinal obstruction.

A 54-year-old man with a history of hypertension and hyperlipidemia was admitted to our hospital complaining of abdominal pain and vomiting. He showed abdominal bloating but no signs of peritoneal irritation. Contrast-enhanced computed tomography (CT) revealed local thickening of the small bowel wall, which was assumed to be due to an inflammatory reaction (Fig. 1). We diagnosed inflammatory disease, administered conservative treatment, which was effective, and did not perform further checkups. After resuming oral intake, he was discharged 10 days after admission. A few days after discharge, however, his abdominal symptoms recurred, and he was readmitted to our hospital.

Contrast-enhanced abdominal computed tomography shows thickening of the small bowel wall. a Axial view. b Coronal view

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Blood tests showed a mild inflammatory reaction and dehydration. The white blood cell count was 8200/μl, with 62.3% neutrophils, 28.3% lymphocytes, 0.7% eosinophils, 0.5% basophils, and 8.3% monocytes. Other laboratory tests showed the following: hemoglobin 14.5 g/dl, platelets 265,000/μl, CEA 7.5 ng/ml, CA19-9 4.5 U/ml, and sIL-2R 313 U/ml. After insertion of an ileus tube, a small bowel series revealed severe obstruction in the jejunum with upstream dilatation (Fig. 2). CT showed that thickening of the jejunal wall was still causing obstruction. Because of the results of those assessments, we performed a laparoscopic exploratory examination for a more accurate diagnosis. The laparoscopic views revealed a hard mass at the stenotic site, prompting us to perform small bowel resection with mesenteric lymph node dissection in consideration that the tumor might be malignant. The surgical view showed a palpable, elastic, hard mass in the jejunum, necessitating partial resection of the jejunum with 10-cm margins from the tumor on both sides and mesenteric lymphadenectomy. During the lymph node dissection of the small intestinal mesentery, we removed seven lymph nodes, none of which showed signs of metastasis.

Small bowel series via the ileus tube shows severe obstruction in the jejunum with upstream dilatation

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Macroscopic examination of the resected specimen revealed a tumor approximately 60 mm in diameter that had caused stenosis of the entire jejunal circumference (Fig. 3). Histologically, hematoxylin and eosin (HE) staining showed diffuse infiltration and expansion of immature, atypical cells but without tissue destruction (Fig. 4). Immunochemical staining revealed that the cells were positive for myeloperoxidase (MPO) and CD34 and negative for CD20 (L26), CD3, CD30 (Ki1), CK (AE1/AE3), CK (MNF116), desmin, CD56, HMB-45, and S-100-protein (Fig. 5). These results confirmed the diagnosis of isolated jejunal MS. The patient’s postoperative recovery was uneventful, and he was discharged from the hospital 9 days after the surgery.

Resected mass measured approximately 60 × 50 mm. The mass, which was elastic and hard, blocked the entire circumference of the elevated cut surface

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Small intestine specimen shows diffuse infiltration and expansion of immature, atypical cells without tissue destruction (HE; a × 20, b × 200)

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Immunohistochemistry shows staining of the tumor cells for myeloperoxidase (MPO) (a) and CD34 (b)

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Although the bone marrow aspiration evaluation was negative for cytological findings of leukemia, and ¹⁸F-fluorodeoxyglucose-positron emission tomography (FDG-PET) showed no abnormal uptake, the patient was started on systemic chemotherapy for AML 6 months after his surgery.

MS occurs as an initial or replacement presentation of AML and sometimes as a complication of myeloproliferative disorders. Isolated MS is rare, with only 1.4–9.0% of AML patients reported to develop MS [3]. Kitagawa et al. reported that the interval between the diagnosis of MS and the occurrence of AML varied from 0.5 to 24 months in patients with initial MS [2]. The male/female ratio is 1.2:1, and the median age was 56 years (range 1 month to 89 years) [4].

Imaging and biopsy results are useful for confirming the diagnosis. FDG-PET shows high uptake by the tumor, and pathological examination shows both diffuse and concentrated areas of hyperplasia with large oval cells [1, 5]. It has been reported, however, that almost half the patients with MS have been misdiagnosed as having a primary or metastatic malignant tumor, especially malignant lymphoma [2, 6]. We did not list MS in the differential diagnosis of the patient and thus arrived at a misdiagnosis. Immunohistochemical examinations (e.g., CD68/KP1, CD33, CD34, CD117, and MPO) are performed to characterize the MS [4]. In our case, MPO was useful for establishing an accurate diagnosis.

Surgical resection is performed to treat an intestinal obstruction, as in our case, but MS patients should be treated with systemic chemotherapy tailored to the AML. Yamauchi and Yasuda analyzed 74 clinical records and showed that the median interval from MS to acute non-lymphocytic leukemia was significantly shorter among the patients who underwent surgical resection with or without irradiation than in those treated with chemotherapy only [6].

MS is rarely seen in the small intestine and certainly would not be easily recognized by general surgeons. Moreover, there is some confusion about the terminology. MS is described as a granulocytic sarcoma (extramedullary myelogenous leukemia) in Diagnostic Surgical Pathology, 3rd Edition published in 1999 and as a granulocytic sarcoma or a chloroma in Surgical Pathology, 10th Edition published in 2011 [7, 8]. Furthermore, it is called a myeloid sarcoma, granulocytic sarcoma, and chloroma in Surgical Pathology, 11th Edition published in 2018 [9]. MS is not even listed In WHO Classification of Tumours of the Digestive System, 4th Edition [10]. Hence, it appears desirable that, in the future, the definition of MS be unified regarding terminology.

In most cases of intestinal MS, patients exhibit symptoms of bowel obstruction. A review of the English-language literature between 2002 and 2019 revealed 18 cases of nonleukemic MS of the small intestine (Table 1). Although the type of treatment was not described in 2 cases, the remaining 16 patients underwent surgical resection. Among these 18 patients, 12 were treated with chemotherapy for AML, all of whom experienced complete remission. Among the remaining 6 patients, 4 were treated with surgery only, and 2 of the 4 developed AML. It is important for patients with MS to have an early, accurate diagnosis and to start treatment for AML as soon as possible.

We report the case of an isolated MS that presented with small bowel obstruction. MS is not well known, and many patients with the disease have been assigned an incorrect diagnosis at their first evaluation. Although it is difficult to confirm the diagnosis—especially when MS precedes the occurrence of AML—it is imperative for MS patients to have an early, definitive diagnosis and to start treatment for AML as rapidly as possible. Therefore, we must cite MS as one of the differential diagnoses of small bowel tumors, even in patients without any symptoms of leukemia.

MS:

Myeloid sarcoma

AML:

Acute myeloid leukemia

CT:

Computed tomography

HE:

Hematoxylin-eosin

MPO:

Myeloperoxidase

FDG-PET:

¹⁸F-fluorodeoxyglucose-positron emission tomography

We thank Nancy Schatken, BS, MT (ASCP), from Edanz Group (www.edanzediting.com/ac), for editing a draft of this manuscript.

Funding

None

Affiliations

1. Department of Surgery, Kindai University Nara Hospital, 1248-1 Otoda, Ikoma, Nara, 630-0293, Japan
   • Rie Mizumoto
   • , Masanori Tsujie
   • , Kotaro Kitani
   • , Hironobu Manabe
   • , Shuichi Fukuda
   • , Kaoru Okada
   • , Shumpei Satoi
   • , Hajime Ishikawa
   • , Masao Yukawa
   •  & Masatoshi Inoue
2. Department of Pathology and Laboratory Medicine, Kindai University Nara Hospital, 1248-1 Otoda, Ikoma, Nara, 630-0293, Japan
   • Tomoko Wakasa
3. Department of Gastroenterology and Hepatology, Kindai University Nara Hospital, 1248-1 Otoda, Ikoma, Nara, 630-0293, Japan
   • Toshihiko Kawasaki
4. Department of Hematology, Kindai University Nara Hospital, 1248-1 Otoda, Ikoma, Nara, 630-0293, Japan
   • Hitoshi Hanamoto

Contributions

RM, KK, HM, TW, SF, KO, SS, MT, GI, TK, MY, and MI participated in the treatment of this patient and wrote the draft of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Masao Yukawa.

Ethics approval and consent to participate

Not applicable

Consent for publication

Written informed consent was obtained from the patient’s next of kin to publish this case report and any accompanying images.

Competing interests

The authors declare that they have no competing interests.

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