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A case of gastric heterotopic pancreas with gastroduodenal invagination
Surgical Case Reportsvolume 5, Article number: 110 (2019)
Heterotopic pancreas (HP) is a rare disease commonly found incidentally on imaging studies, at endoscopy or at autopsy and can be associated with abdominal pain, vomiting, heart burn, gastric outlet obstruction, and even dysphagia in very rare cases. Heinrich’s classified HP into three groups, types1–3, with Heinrich’s type 3 HP the rarest and difficult to diagnose properly because it has only pancreatic ducts but has no islet and acini. The aim of this study is to report a case of gastric outlet obstruction caused by type 3 HP with gastroduodenal invagination with reference to the literature and diagnosed finally by immuno-histochemical analysis.
The case presented is a 40-year-old male presenting with vomiting and abdominal pain. Computed tomography (CT) revealed a cystic mass in the upper abdomen and he was referred to the Tokushima University. Gastric fiber showed that the pedunculated mass originated from the stomach. An open distal gastrectomy was performed. Pathologically, there was small glands proliferation in the sub-mucosal (SM) layer which was membrane and cytoplasm (MUC)1 positive and muscle proliferation.
This finding revealed the tumor as HP. Postoperative course was uneventful and the patient was discharged 12 days after surgery. The patient has remained well 12 months after surgery.
HP should be considered in the differential diagnosis of SM tumors with gastroduodenal invagination even if this is a rare symptom.
Submucosal (SM) tumors are tumors in the submucosa or muscularis propria of the gastric wall and are associated with many types of diseases. Gastrointestinal stromal tumors (GISTs) and leiomyomas are the most common gastric SM tumors. Heterotopic pancreas (HP) is also one of the differential diagnoses for SM tumors but is very rare. It is often difficult to differentiate SM tumors [1, 2], so some imaging examination, such as endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) which has been recently reported to be useful  is essential for a precise diagnosis.
As previously stated, HP is one of the SM tumors and is defined as the presence of pancreatic tissue outside its normal location and without anatomic and vascular continuity with the main body of the pancreas . Usually asymptomatic, gastric heterotopia is commonly an incidental finding on imaging studies, at endoscopy or at autopsy [1, 4]. Only a few cases are shown to be clinically significant, particularly larger lesions, which can be associated with abdominal pain, vomiting, gastric outlet obstruction, and even dysphagia in the very rare cases located near the esophago-gastric junction . Gastric HP is commonly situated in the submucosa of the distal stomach, most often within 50 mm of the pylorus. It is usually seen at endoscopy as a yellowish, soft tumor. The SM location of HP is often evaluated by endoscopic ultrasound with the recognition of features distinguishing it from GISTs and leiomyoma, the major clinical and endoscopic differential diagnoses .
Pathologically, HP is variably composed of pancreatic acini, ducts, or islets. Some cases contain all components of the pancreas, including ducts, acini, and endocrine islets, whereas others consist of pancreatic ducts only. Heinrich named the three types as types 1–3 respectively . HPs have also been termed ‘adenomyomas’ or ‘myoepithelial hamartomas’ [1, 7] and are usually characterized by dilated pancreatic ducts only and surrounded by prominent smooth muscle proliferation. Other cases consist of only acinar tissue, whereas some consist of only islet cells. This study reports a case of gastric outlet obstruction with gastroduodenal invagination of HP with reference to the literature.
A 40-year-old male presented with vomiting and abdominal pain. Computed tomography (CT) revealed a cystic mass in the upper abdomen and the patient was subsequently referred to the Tokushima University. Laboratory tests were as follows: leukocyte count 7400/μl; hemoglobin 8.6 g/dl; albumin 4.0 g/dl; amylase 91 IU/l; total bilirubin 0.3 mg/dl; carcinoembryonic antigen (CEA) 1.5 ng/ml; carbohydrate antigen 19-9 (CA19-9) 8 U/mL; DUPAN-II < 25 U/ml; and S-pancreas-1 antigen (Span-1) 7 U/ml. The CT in the axial view revealed a 6 cm low-density mass in the pylorus of the stomach and a coronal view confirmed gastroduodenal invagination (Fig. 1a, b). Magnetic resonance imaging (MRI) revealed a mass lesion: T1-weighted image (WI) low, T2 WI high, intermediate-high apparent diffusion coefficient (ADC) value, and diffusion-weighted image (DWI) high (Fig. 2). The gastric fiber showed that the pedunculated mass originated from the stomach and the cushion sign was positive (Fig. 3). The tumor was expected to be difficult to resect by endoscopy because of its size and the presence of gastroduodenal invagination. We did not perform ultrasonography (US).
According to these findings, GIST, duplication cyst, malignant lymphoma, and gastric polyp could be stated as a differential diagnosis (Table 1). In particular, MRI finding suggested duplication cyst but gastric duplication has not reported to be accompanied by gastroduodenum invagination. Therefore, the preoperative diagnosis was a SM cystic tumor originating from the stomach with gastroduodenal invagination. An open distal gastrectomy was performed because of its invagination at which time the mass was found in the duodenum 3rd portion and invaginated to the duodenum. It was moved to the stomach and a distal gastrectomy with B-1 reconstruction was performed (Fig. 4). It was unclear whether there was malignant finding.
The resected specimen showed a solid, edematous nodule with small glands originating from the gastric antrum with some of the small glands and the stroma in the SM layer. (Fig. 5). Pathologically, many glands and stroma were found in the SM layer some of these glands were dilated (Fig. 6a, b). Edematous stroma and inflammatory cells were found in SM layer and smooth muscle bundles were found around the glands (Fig. 6c, d). At first, it was diagnosed as SM heterotopic glands of the stomach. However, it was difficult to differentiate from other SM cysts. Immuno-histochemical analysis was performed, which showed positivity on the grands’ membranes and cytoplasm (MUC)1 and negative on MUC2, MUC5AC, and MUC6, which suggested that the grands originated from pancreatic ducts (Fig. 7). This tumor lacked pancreatic acini but the above results of immuno-staining revealed that these atypical tissues were pancreatic ducts and the tumor was HP. The postoperative course was uneventful and the patient was discharged 12 days after surgery and has remained well 12 months after surgery.
SM tumors are divided into a number of groups and GISTs and leiomyomas are the most common of these gastric SM tumors. HP is also one of the differential diagnoses. It is often difficult to differentiate SM tumors into the respective groups . Pang’s retrospective study of thirty-two cases of HP showed that there were no cases which were diagnosed properly before the operations were performed . Regarding an endoscopic study, Kubota’s review of 26 cases of SM tumor suggested that most HPs are yellowish, cloudy, small, soft, and nodular in shape . On the one hand, solid tumors such as neuro-endocrine tumors (NETs) generally extend vertically and are papillary while; on the other hand, soft tumors such as HPs tend to extend horizontally and show cushion sign positive. The case described in this study showed a cushion sign positive which means a soft tumor but with a formed papillary architecture and gastroduodenal invagination, atypical for a soft tumor like HP. And the correlation pedunculated shape and HP’s pathological type was obscure.
The SM location of pancreatic heterotopia is often evaluated using endoscopic ultrasound with the recognition of features distinguishing it from a GIST or leiomyoma, the major clinical and endoscopic differential diagnoses. Moreover, EUS-FNA is reported to be useful  for a precise diagnosis. In the case study, endoscopic biopsy could have been performed at the same time but tissue specimens obtained using standard endoscopic biopsy forceps would not have been adequate for histopathological diagnosis of HP .
It has been reported that the proper diagnosis rate of HP by CT is only 16.7% , while the proper diagnosis rate using MRI is higher. MRI often shows HP as T1 WI high, T2 WI low . In the case study, the mass lesion showed low intensity in T1 WI and high intensity in T2 WI. The density of the tumor’s content suggested that this tumor included water-like content and resembled that of a pancreatic serous cystic neoplasm (SCN) and gastric duplication and was atypical as HP or a GIST. However, the resected specimen was filled with solid tumor. Pathologically, there were many secretory glands and this stroma was edematous, which might show a T2 WI, water-like image. The correlation between image by CT and MRI and pathological type of HP is obscure; however, some reports suggested that the enhancement on CT is typically similar to that of the normal pancreas but the enhancement degree depends heavily on the histopathologic composition. Duct dominant type including type 3 HP exhibits lower enhancement than the normal pancreas . MRI could show the variable image according to HP’s subtype.
Pathologically, HP is variably composed of pancreatic acini, ducts, or endocrine islets. Some cases contain all components of the pancreas, including ducts, acini, and endocrine islets, whereas others consist of pancreatic ducts only. In 1909, Heinrich classified the HP into three types histologically: type 1, the most common, with all the components of the pancreas including acini, ducts, and endocrine islets; type 2, with acini and ducts and no endocrine islets; and type 3, with ducts alone . In the case study, immuno-histochemical analysis showed MUC1-positive cells, which revealed the existence of benign pancreatic ducts, identifying it as belonging to type 3. They are usually characterized by only dilated pancreatic ducts and are surrounded by prominent smooth muscle proliferation while some of them are cystically dilated . In type 3, because only the pancreatic ducts exist, differentiation between HP and SM heterotopic glands is very difficult. The case study was diagnosed as HP because of two reasons. First, the mass expressed MUC1 on the glands’ membranes, which was expressed specifically in the pancreatic glands’ membranes and cytoplasm. Secondly, the muscle proliferation existed in the mass which was also specific to type 3 HP.
HP is usually asymptomatic [1, 13, 14] and commonly found incidentally on imaging studies, at endoscopy or at autopsy. Only a few cases are clinically significant, particularly larger lesions, because they can be associated with abdominal pain, vomiting  and gastric outlet obstruction [5, 16]. Dysphagia and heartburn can occur in the very rare cases when the lesion is located near the esophago-gastric junction [2, 17, 18]. Gastroduodenal invagination is a rare symptom and to the best of the authors’ knowledge, only a few cases of HP as a cause of gastric outlet obstruction in adult have been observed [5, 15, 16, 19,20,21,22,23]. Almost all gastric HP is situated in the submucosa of the distal stomach, and often within 50 mm of the pylorus . This location and the larger size of a tumor may lead to several symptoms similar to the case study where the lesion was near the pylorus and 6 cm in size . About treatment of HP, if HP is discovered as an incidental finding, local excision is recommended. Increasingly, some are removed endoscopically with satisfactory postoperative results . However, endoscopic excision can be considered in select case. In our case, the reduction of incarceration was expected to be difficult endoscopically and laparoscopically, and open strategy was performed. Moreover, the adenocarcinoma could not be excluded completely and DG was performed. In some case, DG was also performed because of obscure diagnosis .
The HP tissue can undergo secondary changes and complications such as acute pancreatitis, pseudo-cyst formation, development of mucinous cysts, and pancreatic intra-epithelial neoplasia [7, 19, 24,25,26]. Rare cases of ectopic pancreatic tissue complicated by adenocarcinoma or even endocrine tumors have been described. In symptomatic lesions, if a preoperative diagnosis can be secured, minimally invasive techniques should be the treatment of choice, including endoscopic resection and laparoscopic surgery [2, 13, 18]. The case study was thought to be difficult to resect completely by endoscopy and showed invagination; therefore, an open gastrectomy was performed.
HP can show vertical progression and gastroduodenal invagination. When experimenting with such a tumor, consideration should be given to HP always being included as a part of differential diagnoses. When the diagnosis is difficult, the histological examination, in particular, immuno-histochemical analysis, for example MUC, can reveal pancreatic ectopia, which is a helpful diagnostic method.
Carbohydrate antigen 19-9
Endoscopic ultrasound-guided fine-needle aspiration
Gastrointestinal stromal tumor
Magnetic resonance imaging
Membrane and cytoplasm
Serous cystic neoplasm
Shimizu M, Park DY. Congenital abnormalities of the stomach. In: Neil AS, Bryan FW, Geraint TW, Joel KG, Gregory YL, Marco RN, editors. MORSON AND DAWSON's gastrointestinal pathology fifth edition. Hoboken: Wiley-Blackwell; 2013. p. 104–9.
Subasinghe D, Sivaganesh S, Perera N, Samarasekera DN. Gastric fundal heterotopic pancreas mimicking a gastrointestinal stromal tumour (GIST): a case report and a brief review. BMC Res Notes. 2016;9:185.
Niimi K, Goto O, Kawakubo K, Nakai Y, Minatsuki C, Asada-Hirayama I, et al. Endoscopic ultrasound-guided fine-needle aspiration skill acquisition of gastrointestinal submucosal tumor by trainee endoscopists: a pilot study. Endosc Ultrasound. 2016;5(3):157–64.
Kobara H, Mori H, Rafiq K, Matsunaga T, Fujihara S, Nishiyama N, et al. Evaluation of gastric submucosal tumors using endoscopically visualized features with submucosal endoscopy. Oncol Lett. 2014;8(1):161–8.
Trifan A, Tarcoveanu E, Danciu M, Hutanasu C, Cojocariu C, Stanciu C. Gastric heterotopic pancreas: an unusual case and review of the literature. J Gastrointestin Liver Dis. 2012;21(2):209–12.
Von Heinrich H. Ein peitrang zur histrologie des sogen akzessorischen pancreas. Virchows Arch. 1909;198:392–401.
Inoue Y, Hayashi M, Arisaka Y, Higuchi K, Egashira Y, Tanigawa N. Adenocarcinoma arising in a heterotopic pancreas (Heinrich type III): a case report. J Med Case Rep. 2010;4:39.
Pang LC. Pancreatic heterotopia: a reappraisal and clinicopathologic analysis of 32 cases. South Med J. 1988;81(10):1264–75.
Oh H, Kim GH, Lee MW, Jeon HK, Baek DH, Lee BE. Magnifying endoscopy with narrow-band imaging for gastric heterotopic pancreas. Endosc Int Open. 2018;6(3):E369–e75.
Cho JS, Shin KS, Kwon ST, Kim JW, Song CJ, Noh SM, et al. Heterotopic pancreas in the stomach: CT findings. Radiology. 2000;217(1):139–44.
Fujimoto A, Goto O, Takeuchi H, Koguchi Y, Akimoto T, Mitsunaga Y, Ochiai Y, Maehara T, Mishizawa T, Uraoka T, Hoseo N, Ohara K, Kameyama K, Jawakubo H, Kitagawa Y, Yahagi N. Clinically difficult to diagnose heterotopic pancreas in the stomach, report of a case. I to Cho. 2017;52(10):1361–5.
Lin YM, Chin NC, Li AF, Liu CA, Chou YH, Chiou YY. Unusual gastric and tumor-like lesions: radiological with pathological correlation and literature review. World J Gastroenterol. 2017;23(14):2493–504.
Gokhale UA, Nanda A, Pillai R, Al-Layla D. Heterotopic pancreas in the stomach: a case report and a brief review of the literature. Jop. 2010;11(3):255–7.
Kilius A, Samalavicius NE, Danys D, Zaldokas G, Seinin D. Asymptomatic heterotopic pancreas in Meckel's diverticulum: a case report and review of the literature. J Med Case Rep. 2015;9:108.
Christodoulidis G, Zacharoulis D, Barbanis S, Katsogridakis E, Hatzitheofilou K. Heterotopic pancreas in the stomach: a case report and literature review. World J Gastroenterol. 2007;13(45):6098–100.
Jiang LX, Xu J, Wang XW, Zhou FR, Gao W, Yu GH, et al. Gastric outlet obstruction caused by heterotopic pancreas: a case report and a quick review. World J Gastroenterol. 2008;14(43):6757–9.
Filip R, Walczak E, Huk J, Radzki RP, Bienko M. Heterotopic pancreatic tissue in the gastric cardia: a case report and literature review. World J Gastroenterol. 2014;20(44):16779–81.
Rimal D, Thapa SR, Munasinghe N, Chitre VV. Symptomatic gastric heterotopic pancreas: clinical presentation and review of the literature. Int J Surg. 2008;6(6):e52–4.
Huang YC, Chen HM, Jan YY, Huang TL, Chen MF. Ectopic pancreas with gastric outlet obstruction: report of two cases and literature review. Chang Gung Med J. 2002;25(7):485–90.
Ikematsu Y, Nishiwaki Y, Kida H, Iwaoka Y, Nagashima S, Ozawa T, et al. Gastric outlet obstruction caused by a heterotopic pancreas in a pregnant woman: report of a case. Surg Today. 2003;33(12):952–5.
Eisenberger CF, Kropp A, Langwieler TE, Gocht A, Izbicki JR, Knoefel WT. Heterotopic pancreatitis: gastric outlet obstruction due to an intramural pseudocyst and hamartoma. Z Gastroenterol. 2002;40(4):259–62.
Agale SV, Agale VG, Zode RR, Grover S, Joshi S. Heterotopic pancreas involving stomach and duodenum. J Assoc Physicians India. 2009;57:653–4.
Ayantunde AA, Pinder E, Heath DI. Symptomatic pyloric pancreatic heterotopia: report of three cases and review of the literature. Med Sci Monit. 2006;12(6):Cs49–52.
Fukino N, Oida T, Mimatsu K, Kuboi Y, Kida K. Adenocarcinoma arising from heterotopic pancreas at the third portion of the duodenum. World J Gastroenterol. 2015;21(13):4082–8.
Tong L, Pan H, He J, Weng M, Zheng L. Hepatoid adenocarcinoma arising from heterotopic pancreas of the ileum: a case report. Medicine (Baltimore). 2016;95(33):e4067.
Yoon JB, Lee BE, Kim DH, Park DY, Jeon HK, Baek DH, et al. A rare case of early gastric cancer combined with underlying heterotopic pancreas. Clin Endosc. 2018;51(2):192–5.
NM is the corresponding author and carried out the revision of the manuscript. All the authors equally took part in the conception of the case study; acquisition, analysis, or interpretation of data; drafting and revising of the paper; final approval of the paper; and agreement to be accountable for the integrity of the case report. All authors read and approved the final manuscript.
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