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  • Case Report
  • Open Access

Metastatic colonic and gastric polyps from breast cancer resembling hyperplastic polyps

  • 1, 2Email author,
  • 3,
  • 4,
  • 5 and
  • 1
Surgical Case Reports20184:23

https://doi.org/10.1186/s40792-018-0433-4

  • Received: 7 December 2017
  • Accepted: 13 March 2018
  • Published:

Abstract

Breast cancer metastasis to the gastrointestinal tract is relatively rare and is generally found when patients complain of symptoms such as gastrointestinal obstruction. Herein, we report a case with metastatic colonic and gastric lesions from breast cancer, with the formation of mucosal polyps which resembled typical hyperplastic polyps.

A 47-year-old woman underwent curable surgery for breast cancer and received standard systemic treatments. Her primary tumor was composed of a mix of invasive lobular and ductal carcinomas. During adjuvant endocrine therapy, she developed multiple colonic metastases, identified by colonoscopy performed as part of a general health check-up. She had no symptoms. Small elevated sessile polyps in the transverse colon and rectum showed histological features of signet-ring cell type adenocarcinoma, similar to the invasive lobular component of the primary breast cancer. During treatments for recurrent disease, she also developed multiple gastric metastases, with the same endoscopic and pathological features as the colonic lesions. Her treatment regimen was switched to oral chemotherapy, and she has since maintained stable disease for nearly 3 years. Multiple bone metastases eventually developed, and she was again switched to another systemic treatment but, to date, has remained free of symptoms.

We emphasize that the endoscopic findings of the metastatic lesions in the colon and stomach in this case highly resembled hyperplastic polyps. Since biopsy is not always performed for hyperplastic polyps in the gastrointestinal tract, we believe that this case report may encourage endoscopists to offer biopsies to the patient who has a history of breast cancer.

Keywords

  • Breast cancer
  • Lobular carcinoma
  • Colonic metastasis
  • Mucosal metastatic polyp

Background

Breast cancer rarely metastasizes to the gastrointestinal (GI) tract, and only 5% of patients with recurrent disease have GI metastasis [1]. Invasive lobular carcinoma (ILC), which is characterized by minimal cell-cell adhesion, is known to more often metastasize to the GI tract than invasive ductal carcinoma (IDC), and this is especially true of ILC of the signet-ring cell type [2, 3].

In making the differential diagnosis of metastatic disease, several immunohistochemical (IHC) markers are useful for identifying breast cancer as the primary tumor. Estrogen receptor (ER) and human epidermal growth factor receptor 2 (HER2) are often examined, but their expressions are detected in 12–25% and 20% of gastric cancers [46], and in 30–56% and 4–14% of colon cancers [710], respectively. Thus, these examinations are not sufficient, in terms of tissue specificity, for identifying the origin of metastasis. CK7 is often observed in the epithelial layers of breast ducts and the lungs, while intestinal tissues show no expression of this protein [11, 12]. On the contrary, CK20 is often expressed in the large intestine and bile ducts, while it is rarely seen in the breast [11, 12]. Thus, metastatic disease from breast cancer is expected to be CK7-positive and CK20-negative, while the opposite is generally seen in primary colon cancer. GCDFP-15 and mammaglobin are also widely used. GCDFP-15, one of the proteins comprising the walls of benign cysts of the breast, is expressed in 32–47% of breast cancer metastatic lesions [13, 14]. Mammaglobin expression, observed only in breast and skin tissues, is also positive in 42–87% of metastases from breast cancer [1315].

GI metastasis is typically found when patients complain of symptoms such as GI obstruction. At this stage, GI tract metastasis of ILC reportedly shows macroscopic findings of linitis plastic in some cases, rather than forming a large, localized, and elevated lesion [1620].

Herein, we report a rare case with metastatic colonic mucosal polyps from breast cancer, which had an entirely hyperplastic appearance, and produced no symptoms. Metastasis localized only in the GI mucosa, verified endoscopically [18] or surgically [19], is very rare.

Case presentation

A 47-year-old woman felt a lump in her left breast and came to our hospital. We diagnosed invasive breast cancer (cT2N1M0 Stage IIB) and administered primary systemic chemotherapy (FEC × 4 cycles followed by Docetaxel × 4 cycles). Clinically, a complete response was obtained and she then underwent mastectomy (Bt+Ax). Pathological findings of the operative specimen were a mix of ILC and IDC. The ILC component had lost E-cadherin expression, and some cells showed signet-ring cell carcinoma features (Fig. 1a,b). Pathologically, the tumor was 105 mm in diameter and metastasis was detected in one lymph node; the histological features were consistent with ILC, while no lymphovascular involvement was detected (pT3N1aM0 Stage IIIA). The chemotherapy effect was grade 2, according to the general rules for Clinical and Pathological Recording of Breast Cancer (17th edition) by the Japanese Breast Cancer Society. ER and progesterone receptor (PR) were both positive and HER2 was negative. These IHC results were consistent with both the IDC and the ILC components. Following surgery, she received adjuvant endocrine therapy with a selective estrogen receptor modulator (SERM) for 2 years followed by sequential aromatase inhibitor (AI). Since she suffered from fatigue, the treatment was switched to SERM 4 years and 4 months after surgery. Eight months later, she underwent colonoscopy at another hospital as part of a general health check-up. She had no symptoms. A small elevated sessile polyp (4 mm in diameter) was found in the transverse colon (Fig. 2a) and was removed endoscopically. Histologically, adenocarcinoma (signet-ring cell type) was observed in the mucosa of the transverse colon (Fig. 3a). Because the histological type was not one commonly seen in colon cancer cases, biopsy specimens were reviewed at our hospital and compared with that of the primary breast cancer. Immunohistochemical examination revealed the polyp to be ER positive, PR negative, HER2 negative, E-cadherin negative, Cytokeratin (CK) 7 positive, CK20 negative, gross cystic disease fluid protein (GCDFP-15) positive, and mammaglobin negative (Fig. 3ae). Based on histological similarity and the results of additional IHC examinations, we concluded that the polyp represented metastasis from the original breast cancer. We performed computed tomography and positron emission tomography at the time of diagnosis of recurrent disease, but no distant metastases, including the colonic polyp, were detected by these examinations.
Fig. 1
Fig. 1

Pathological findings of primary breast cancer. a Invasive lobular carcinoma in primary breast lesion: discohesive small round cells (E-cadherin negative) are arranged in slender strands (Hematoxylin and eosin staining (HE), × 400). b Signet-ring cell features (blue arrows) were observed in the invasive lobular carcinoma lesion of the primary breast cancer (× 400)

Fig. 2
Fig. 2

Metastatic mucosal polyp in transverse colon. a A small elevated sessile polyp (4 mm in diameter) was found in the transverse colon. Polypectomy was endoscopically performed and pathological examination revealed it to be a signet-ring cell carcinoma. b Multiple metastatic polyps in the transverse colon: re-examination by colonoscopy, performed 4 months after the diagnosis of metastasis, showed an increase in the numbers of metastatic polyps throughout the large intestine. Five biopsies were taken from the ascending colon, transverse colon, and rectum and all were confirmed to be signet-ring cell carcinoma

Fig. 3
Fig. 3

Pathological findings of metastatic colonic polyp (HE). a Adenocarcinoma (signet-ring cell type) in the mucosa of the transverse colon (× 200). be The metastatic mucosal polyp was CK7 positive, CK20 negative, GCDFP-15 positive, and mammaglobin negative (b, c, d, and e, respectively, × 200). These expressions corresponded to those of the primary breast cancer lesion

Since the metastases were diagnosed 8 months after starting SERM, which had been preceded by AI as adjuvant therapy, the patient restarted treatment with the initial AI. Colonoscopy, performed 2 months later, revealed that the numbers of small polyps had increased and were present throughout the large intestines (Fig. 2b). Five biopsies in total were taken from the ascending and transverse portions of the colon and the rectum, and all showed the same histological features as the signet-ring cell carcinoma polyp. However, on re-examination 4 months later, the numbers of polyps had obviously decreased, indicating the endocrine treatment to be effective. The patient maintained a stable disease state with this treatment for 1 year after the initial diagnosis of metastases. However, she eventually developed multiple small white elevated lesions (Fig. 4a), which had not been present at the time of initial diagnosis of the recurrent disease. We confirmed these gastric lesions to have the same pathological features, signet-ring cell type adenocarcinoma (Fig. 4b), as the colonic lesions, despite having the appearance of hyperplastic polyps. The gastric polyps showed the same expression pattern, with CK7, CK20, GCDFP-15, and mammaglobin being positive, negative, positive, and negative, respectively. She started treatment with capecitabine, and the gastric lesions remained stable for 2 years and 7 months, while the colonic lesions had almost disappeared within 10 months of starting this drug. She eventually developed multiple bone metastases, and her systemic treatment was switched to another chemotherapeutic regimen.
Fig. 4
Fig. 4

Multiple metastatic gastric polyps. Gastrointestinal fiberscopy revealed multiple small white elevated polyps in the stomach (a), which had not been seen at the time of the initial diagnosis of recurrent disease of the colon. Pathological findings (b, HE, × 200) confirmed signet-ring cell carcinoma

Throughout her clinical course, she has remained free of symptoms, suffering neither abdominal pain nor melena.

Conclusions

We could not ascertain whether the metastases represented mucosal lesions if the patient had not undergone a routine health check-up. Otherwise, she might have progressed to a severe condition, such as GI perforation or obstructive ileus. Instead, this patient has been free of symptoms for more than 5 years with adequate systemic therapies against recurrent diseases.

We emphasize that, based on the endoscopic findings, these colonic and gastric metastatic lesions essentially had the appearance of hyperplastic polyps. Since biopsy is not consistently performed for hyperplastic polyps in the GI tract, this case report may encourage endoscopists to offer biopsies to patients with a history of breast cancer. Whether or not this endoscopic appearance indicates early GI metastasis needs to be determined based on further case reports.

Abbreviations

AI: 

Aromatase inhibitor

CK: 

Cytokeratin

ER: 

Estrogen receptor

GI: 

Gastrointestinal

HER2: 

Human epidermal growth factor receptor 2

IDC: 

Invasive ductal carcinoma

IHC: 

Immunohistochmical

ILC: 

Invasive lobular carcinoma

PR: 

Progesterone receptor

SERM: 

Selective estrogen receptor modulator

Declarations

Authors’ contributions

YH and TH identified the unusual features of this case. YH wrote the article. TH performed endoscopy and provided all endoscopic images for the article. AA was the principal pathologist and supplied all of the pathology images. YH, HM, and MS were responsible for overall care of the patient. MS critically revised the manuscript for content. All authors read and approved the final manuscript.

Ethics approval and consent to participate

Not applicable.

Consent for publication

Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.

Competing interests

The authors declare that they have no competing interests.

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Authors’ Affiliations

(1)
Department of Breast Oncology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
(2)
Department of Pathology and Oncology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
(3)
Tamaplaza South Gastrointestinal Clinic, 3-14-12 Shinishikawa, Aoba-ku, Yokohama-shi Kanagawa, 225-0003, Japan
(4)
Department of Human Pathology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
(5)
Department of Surgery, Koshigaya Municipal Hospital, 10-47-1 Higashikoshigaya, Koshigaya Saitama, 343-8577, Japan

References

  1. Mukaiyama T, Ogawa M, Horikoshi N, Inoue K, Inagaki J, Egaki K, Kasumi F, Nishi M, Sakamoto G. Analysis of metastatic behaviors and causes of death in 100 autopsied patients with breast cancer. Jpn. J. Breast Cancer. 1989;4:121–6.Google Scholar
  2. Arpino G, Bardou VJ, Clark GM, Elledge RM. Infiltrating lobular carcinoma of the breast: tumor characteristics and clinical outcome. Breast Cancer Res. 2004;6:R149–56.View ArticlePubMedPubMed CentralGoogle Scholar
  3. Merino MJ, Livolsi VA. Signet-ring cell carcinoma of the breast. Cancer. 1981;48:1830–7.View ArticlePubMedGoogle Scholar
  4. Chandanos E, Rubio CA, Lindblad M, Jia C, Tsolakis AV, Warner M, Gustafsson JA, Lagergren J. Endogenous estrogen exposure in relation to distribution of histological type and estrogen receptors in gastric adenocarcinoma. Gastric Cancer. 2008;11:168–74.View ArticlePubMedGoogle Scholar
  5. Gan L, He J, Zhang X, Zhang Y, Yu G, Chen Y, Pan J, Wang J, Wang X. Expression profile and prognostic role of sex hormone receptors in gastric cancer. BMC Cancer. 2012;12:566.View ArticlePubMedPubMed CentralGoogle Scholar
  6. Bang Y-J, Van Cutsem E, Feyereislova A, Chung HC, Shen L, Sawaki A, Lordick F, Ohtsu A, Omuro Y, Satoh T, Aprile G, Kulikov E, Hill J, Lehle M, Rüschoff J, Kang Y-K. Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial. Lancet. 2010;376:687–97.View ArticlePubMedGoogle Scholar
  7. Alford TC, Do HM, Geelhoed GW, Tsangaris NT, Lippman ME. Steroid hormone receptors in human colon cancers. Cancer. 1979;43:980–4.View ArticlePubMedGoogle Scholar
  8. Marugo M, Molinari F, Fazzuoli L, Parodi MC, Bernasconi D, Menozzi F, Giordano G. Estradiol and progesterone receptors in normal and pathologic colonic mucosa in humans. J Endocrinol Investig. 1985;8:117–9.View ArticleGoogle Scholar
  9. Nathanson DR, ATt C, Shia J, Chen B, D'Alessio M, Zeng ZS, Nash GM, Gerald W, Barany F, Paty PB. HER 2/neu expression and gene amplification in colon cancer. Int J Cancer. 2003;105:796–802.View ArticlePubMedGoogle Scholar
  10. Li Q, Wang D, Li J, Chen P. Clinicopathological and prognostic significance of HER-2/neu and VEGF expression in colon carcinomas. BMC Cancer. 2011;11:277.View ArticlePubMedPubMed CentralGoogle Scholar
  11. Weiss LM, Chu PG. Immunohistochemical characterization of signet-ring cell carcinomas of the stomach, breast, and Colon. Am J Clin Pathol. 2004;121:884–92.View ArticlePubMedGoogle Scholar
  12. Tot T. The role of cytokeratins 20 and 7 and estrogen receptor analysis in separation of metastatic lobular carcinoma of the breast and metastatic signet ring cell carcinoma of the gastrointestinal tract. APMIS. 2000;108:467–72.View ArticlePubMedGoogle Scholar
  13. Luo M-H, Huang Y-H, Ni Y-B, Tsang JYS, Chan S-K, Shao M-M, Tse GM. Expression of mammaglobin and gross cystic disease fluid protein-15 in breast carcinomas. Hum Pathol. 2013;44:1241–50.View ArticlePubMedGoogle Scholar
  14. Yan Z, Gidley J, Horton D, Roberson J, Eltoum IE, Chhieng DC. Diagnostic utility of mammaglobin and GCDFP-15 in the identification of metastatic breast carcinoma in fluid specimens. Diagn Cytopathol. 2009;37:475–8.View ArticlePubMedGoogle Scholar
  15. Bhargava R, Beriwal S, Dabbs DJ. Mammaglobin vs GCDFP-15: an immunohistologic validation survey for sensitivity and specificity. Am J Clin Pathol. 2007;127:103–13.View ArticlePubMedGoogle Scholar
  16. Winston CB, Hadar O, Teitcher JB, Caravelli JF, Sklarin NT, Panicek DM, Liberman L. Metastatic lobular carcinoma of the breast: patterns of spread in the chest, abdomen, and pelvis on CT. AJR Am J Roentgenol. 2000;175:795–800.View ArticlePubMedGoogle Scholar
  17. Arrangoiz R, Papavasiliou P, Dushkin H, Farma JM. Case report and literature review: metastatic lobular carcinoma of the breast an unusual presentation. Int J Surg Case Rep. 2011;2:301–5.View ArticlePubMedPubMed CentralGoogle Scholar
  18. Takeuchi H, Hiroshige S, Yoshikawa Y, Kusumoto T, Muto Y. A case of synchronous metastasis of breast cancer to stomach and colon. Anticancer Res. 2012;32:4051–5.PubMedGoogle Scholar
  19. Matsuda I, Matsubara N, Aoyama N, Hamanaka M, Yamagishi D, Kuno T, Tsukamoto K, Yamano T, Noda M, Ikeuchi H, Tomita N, Hirota S. Metastatic lobular carcinoma of the breast masquerading as a primary rectal cancer. World J Surg Oncol. 2012;10:231.View ArticlePubMedPubMed CentralGoogle Scholar
  20. Eljabu W, Finch G, Nottingham J, Vaingankar N. Metastatic deposits of breast lobular carcinoma to small bowel and rectum. Int J Breast Cancer. 2011;2011:413949.View ArticlePubMedPubMed CentralGoogle Scholar

Copyright

© The Author(s). 2018

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