- Case report
- Open Access
Giant left atrial myxoma causing acute ischemic stroke in a child
© The Author(s). 2018
- Received: 19 October 2017
- Accepted: 21 December 2017
- Published: 12 January 2018
Ischemic stroke is uncommon in pediatric populations and is sometimes caused by cardiac myxoma. In such cases, neurological deficits initially present in ischemic stroke due to emboli or thrombi of the myxoma. Echocardiography is helpful to diagnose myxoma in a timely manner and allows urgent surgical resection of the myxoma. We report a successful case of myxoma in a 7-year-old boy who initially presented with left-sided hemiparesis.
- Ischemic stroke
Ischemic stroke is uncommon in pediatric populations, particularly that caused by primary cardiac tumor. We report a rare case of a 7-year-old boy who presented with left-sided hemiparesis caused by ischemic stroke due to left atrial myxoma.
Ischemic stroke in children is extremely rare, with a reported incidence of 2–13 cases per 100,000 children . This clinical condition increases long-term morbidity (50–80%) and mortality (up to 20%) . In children, ischemic stroke can be caused by conditions such as tumor, endocarditis, vasculopathy, thrombotic disorders, and inflammatory disorders [3, 4]. Ischemic stroke due to myxoma in children younger than 18 years old is extremely rare. Only 17 cases have been reported in the literature .
Also, primary cardiac tumor is uncommon in pediatric populations. Myxoma is the most common in adults but is the third most next to rhabdomyoma and fibroma in children . Because the myxomas are gelatinous and fragile, these sometimes cause ischemic stroke in the children also. Myxoma in children reveals various symptoms depending on the size and location, and therefore, it is difficult to diagnose appropriately.
Many of the patients with myxoma present with one or more symptoms of Goodwin’s triad, which include embolism, intracardiac obstruction, and constitutional symptoms . Embolism is the most common symptom in atrial myxoma, which occurs in 20–45% of myxomas, so neurological deficits due to embolic stroke are the first symptoms of myxoma in some cases [2, 3]. Peripheral cutaneous embolic phenomena have also been reported as “red spots” or “rash,” which often presents before cerebral ischemic events [2, 3]. In children, particularly infants, intracardiac obstruction is more common than stroke, because of the small heart cavity. Congestive heart failure was seen in 64% of infant patients . Constitutional symptoms in myxoma patients typically include fever, weight loss, fatigue, and dizziness.
In our case, the patient presented with dizziness and nausea once a week from 1 year before admission. These symptoms might have represented constitutional symptoms of myxoma and some emboli or thrombi of myxoma causing minor strokes in the brain. If echocardiography had been performed at that time, cardiac myxoma might have been detected earlier at a smaller size. On this admission, echocardiography was immediately performed after he presented with neurological deficit. This allowed us to perform emergent tumor resection and prevented occurring additional embolism due to myxoma.
Cardiac myxoma in children is uncommon but sometimes causes ischemic stroke and further complications due to thrombi or emboli. Emergent resection of the tumor is the best treatment at present for children and thus warrants immediate and precise diagnosis. Our experience suggests that echocardiography should be performed when children present with unusual neurological deficits.
None of authors received any funding.
HI wrote this case report and HK supervised the writing of the report. NI, SN, and HK performed the surgery. All authors read and approved the final manuscript.
Consent for publication
Written informed consent was obtained from the families of the patient for scientific activity including publication of this case report.
All authors declare that they have no competing interests.
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- Lynch JK, Hirtz DG, DeVeber G, Nelson KB. Report of the National Institute of Neurological Disorders and Stroke workshop on perinatal and childhood stroke. Pediatrics. 2002;109:116–23.View ArticlePubMedGoogle Scholar
- Jenifer F, David L, Don M. Cardiac myxoma causing acute ischemic stroke in a pediatric patient and a review of literature. Pediatr Neurol. 2014;50:525–9.View ArticleGoogle Scholar
- Al-Mateen M, Hood M, Trippel D, Samuel JI, Otto RK, Vitikanen KJ. Cerebral embolism from atrial myxoma in pediatric patients. Pediatrics. 2003;112:e162–7.View ArticlePubMedGoogle Scholar
- van den Wijngaard I, Wermer M, van Walderveen MA, Wiendels N, Peeters-Scholte C, Lycklama GJ. Intra-arterial treatment in a child with embolic stroke due to atrial myxoma. Interv Neuroradiol. 2014;20:345–51.View ArticlePubMedPubMed CentralGoogle Scholar
- Sernich S, Chauhan A, Singh D, Fuchs H, Caspi J. Left atrial myxoma in a child: a challenging diagnosis of rare lesion. World Journal for Pediatric and Congenital Heart Surgery. 2012;4(2):220–2.View ArticleGoogle Scholar