Wandering liver and intestinal malrotation: first report
© The Author(s). 2016
Received: 8 January 2016
Accepted: 23 July 2016
Published: 6 August 2016
A wandering liver is a rare development in both the adult and pediatric population where the liver is freely displaced along a transverse axis. We describe the first known occurrence in published literature of a wandering liver in an adult individual who also had an intestinal malrotation complicated by a midgut volvulus. The abnormal ability for a liver to wander presents a highly unusual anatomy that can be disorienting. Laparoscopic surgery is a viable option in reducing a midgut volvulus and addressing an intestinal malrotation in the presence of a wandering liver. This unusual presentation educates clinicians to avoid potential misdiagnosis given the abnormal location of the duodenum, appendix, liver, and gallbladder.
KeywordsWandering liver Intestinal malrotation Laparoscopic surgery Hepatic suspensory apparatus
Wandering liver is a term used to describe a rare development, resulting from a structural malformation in the hepatic suspensory apparatus, in which the liver is free to displace along the transverse axis around the inferior vena cava. Both congenital and—more commonly—acquired forms of wandering liver have been described . This anomaly is thought to arise in conjunction with a persistent ventral mesentery, which may incite a volvulus of the stomach and bowel . In this report, we describe the first known presentation of a wandering liver and intestinal malrotation in an adult resulting in acute midgut volvulus.
Postoperatively, the patient experienced an ileus and recovered uneventfully while regaining bowel function and tolerating diet by postoperative day 3. At 2 weeks of follow-up, resolution of symptoms was demonstrated.
A wandering or hypermobile liver in both the adult and pediatric population is rare in nature and the reported literature. A total of 11 cases since 1960 have been published in medical journals. Various distinct pathologies are associated with this condition in volvulus and/or obstruction of the stomach and bowel due to a persistent ventral mesogastrium [2, 3]. To our knowledge, this is the first reported occurrence of a concurrent wandering liver and intestinal malrotation in an individual. The incident was additionally complicated by a midgut volvulus with diverticulosis in full length of the small bowel.
The hepatic suspensory apparatus, which suspends the liver from the diaphragm and maintains the liver in the right upper quadrant of the abdomen, is made up of the coronary, triangular, and falciform ligaments . A persistent ventral mesentery is known to be associated with malrotation and volvulus; however, because the ligaments of the hepatic suspensory apparatus are derived from the ventral mesentery before it fuses with the peritoneum, it has been proposed that a persistent ventral mesentery could represent an arrest in the normal development of these ligaments, which predisposes them to laxity, allowing the liver to “wander” [2, 3].
Intestinal malrotation diagnosed at adult age is a rather rare finding and typically asymptomatic. Authors Nichols et al.  proposed an embryologic error that may result in the laxity or absence of both hepatic and colonic suspensory ligaments in the setting of colonic volvulus. We agree on this notion of developmental error; however, present literature does not offer any link of hepatic hypermobility to intestinal malrotation or volvulus. Nonetheless, malrotation is reported in 1:500 live births before one month of age with, essentially, no mention of a wandering liver . The impression that a wandering liver is an independent entity as opposed to a clinical sign in a syndrome requires more reported incidences for epidemiologic investigation.
In adult life, intestinal malrotation is generally an incidental finding on CT  and exceptionally infrequent in the setting of a wandering liver. This combination can be discovered during abdominal surgeries for different reasons or present as bowel obstruction. Recurrent episodes of bowel obstruction can occur with the potential of partial or complete volvulus. When symptomatic, prompt intervention (which could be performed laparoscopically) is indicated. Thus, a systemic approach to intestinal malrotation with a wandering liver is crucial in recognizing abnormal anatomy (i.e., duodenal obstruction) especially when approached laparoscopically.
In this case presentation, the preoperative CT scan demonstrated the liver to be midline of anterior abdomen. Upon insufflation and entering the abdomen laparoscopically, the liver was positioned in the left upper quadrant. With manipulation of the liver and positioning of the patient on the operating table, the unimpeded laxity of the hepatic ligaments was manifested within the upper abdominal cavity. This may indicate the competency of the liver to wander in abbreviated times as opposed to a long migratory process. Although not established, the short wandering time may increase predisposition to bowel obstruction in the presence of intestinal malrotation. Figure 1 exhibits liver migration within years of each other. However, on basis of laparoscopic exploration, a wandering liver suggests the ability to migrate in varying locations within hours. Hepatic displacement appears to be independent of any intra-abdominal pathology, i.e., bowel obstructions.
In the treatment approach of concurrent intestinal malrotation and wandering liver, identifying Ladd’s bands is critical for long-term success. The Ladd procedure remains the initial and mainstay procedure for intestinal malrotation in reducing any volvulus, dividing mesenteric bands, and performing an appendectomy. Compared to the open approach, laparoscopic correction may result in a shorter hospital length of stay and incite fewer adhesions with improved outcomes in postoperative pain.
This case explores the possibility for an association of both an intestinal malrotation and wandering liver in the adult population. An intestinal malrotation and midgut volvulus warrant prompt investigation and surgical intervention. It remains imperative that a wandering liver on incidental radiologic studies be monitored for the development of abdominal pathologies as varying hepatic displacements may occur in short timeframes. Clinicians must possess a high level of suspicion with this rare disorder to avoid potential misdiagnosis or delay in treatment given the abnormal location of multiple organs including the duodenum, appendix, liver, and gallbladder.
Consent for publication
Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
The authors Alex Ordonez, Davi Nguyen, Stephanie Mlacker, Andrea Ordonez, Emanuele Lo Menzo, Samuel Szomstein, and Raul Rosenthal have no additional acknowledgements to declare.
AO, DN, SM, ANO, EM, SS, and RR contributed to the case report conception and design. AO, DN, SM, and ANO contributed to the acquisition of data. AO, DN, EM, SS, and RR contributed to the analysis and interpretation of data. AO, DN, SM, ANO, EM, SS, and RR drafted the manuscript. AO, DN, EM, and RR helped in the critical revision. All authors conceived of the case report and participated in its design and coordination and helped to draft the manuscript. All authors read and approved the final manuscript.
The authors declare that they have no competing interests.
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- Bauones S, Hoang H, Roman C, Hery G, Delarue A, Petit P, Gorincour G. Wandering liver: ultrasound and magnetic resonance imaging diagnosis. J Pediatr Surg. 2012;47:e21–5.View ArticlePubMedGoogle Scholar
- Tatekawa Y. Gastric volvulus associated with a wandering liver: a case report and review of the literature. J Gastrointest Surg. 2011;15:2267–70.View ArticlePubMedGoogle Scholar
- Nichols B, Figarola M, Standley T. A wandering liver. Pediatr Radiol. 2010;40:1443–5.View ArticlePubMedGoogle Scholar
- Papadimitriou G, Marinis A, Papakonstantinou A. Primary midgut volvulus in adults: report of two cases and review of the literature. J Gastrointest Surg. 2011;15:1889–92.View ArticlePubMedGoogle Scholar
- Stewart D, Colodny A, Daggett W. Malrotation of the bowel in infants and children: a 15 year review. Surgery. 1976;79:716–20.PubMedGoogle Scholar