A case of splenic metastasis of ovarian cancer treated with complete laparoscopic splenectomy and transvaginal specimen extraction
© Takase et al. 2016
Received: 16 October 2015
Accepted: 3 March 2016
Published: 14 March 2016
A 61-year-old woman was diagnosed with right inguinal lymph node and splenic metastasis of ovarian serous cystadenocarcinoma. We performed right inguinal lymph node dissection and total laparoscopic splenectomy in the supine position followed by transvaginal specimen extraction (TVSE). First, using three ports, we extracted the right inguinal lymph node. We repaired the posterior wall of the inguinal canal using a mesh plug. We added two ports and displaced the spleen from the retroperitoneum and lifted it using a snake retractor, disconnecting the hilum using an automatic suturing device. Next, the posterior wall of the vagina was intraperitoneally incised. And an Alexis® laparoscopic system was inserted into the vagina. The cap maintained aeroperitoneum, a collection bag was inserted in the abdominal cavity via the vagina, and the spleen was collected. When the spleen was removed from the body, partial fragmentation of the organ was required in the bag. Organ fragmentation was performed only within the bag, and we made sure not to tear the bag. The vaginal wound was laparoscopically sutured. The patient had no operative complications and was able to actively ambulate at the first day after surgery due to a slight postoperative pain. Total laparoscopic splenectomy with TVSE in the supine position may be a safe and feasible method for selected female patients. This technique enables minimally invasive surgery for female patients with splenic disease.
Complete laparoscopic splenectomy is defined as a surgical technique in which all surgical maneuvers are performed through ports . However, spleen extraction requires a small incision in the abdomen. To explore an even less invasive form of laparoscopic surgery, “natural orifice transluminal endoscopic surgery” (NOTES), in which the surgical maneuvers and organ extraction are performed through natural orifices without creating abdominal wounds, has been attempted [2, 3]. NOTES has the major advantage of circumventing the requirement for developing a small abdominal incision; however, NOTES still has technical issues and difficulties with regard to its clinical application . “Natural orifice specimen extraction” (NOSE) techniques that are similar to NOTES have been attempted in recent years. Transvaginal specimen extraction (TVSE), one of these techniques, has been attempted mainly in Europe and the USA, and it is claimed to have the advantages of reducing surgical wound pain, reducing wound complications, shortening the period of hospitalization, and ensuring excellent esthetic outcomes [5–10].
Here, we describe a case in which we performed splenectomy in the supine position and extracted the specimen transvaginally to avoid abdominal incision. Widespread experience with laparoscopic pancreatectomies has allowed safe splenectomies in the supine position, by a safe and even less invasive surgical method using TVSE without the changing of body positions as required in conventional laparoscopic splenectomy [5–10]. The present surgical procedure was performed after obtaining approval from the Japanese Meabashi Red Cross hospital ethical committee.
Here, we describe laparoscopic transvaginal splenectomy in a patient with splenic metastasis of ovarian cancer. To the best of our knowledge, this is the first report in the world about splenectomy using an extremely minimally invasive surgical method. A report on complete laparoscopic splenectomy has been published in 2013, but in that case, a hysterectomy was needed because of hypermenorrhea; therefore, the report focused on the use of the transvaginal route developed at the time of the hysterectomy . In this case, the patient had undergone total hysterectomy. We accessed the transvaginal route from the beginning with a view of performing TVSE; thus, the intent of TVSE in the two reports differs.
The main advantages of this technique are as follows. It avoids the destruction of the abdominal wall and eliminates visible scars, decreasing the risk of abdominal hernia . Furthermore, it also decreases postoperative pain and the risk of surgical site infection (SSI) . In this case, the patient did not require any postoperative analgesics, and there was no SSI. Generally, obese patients tend to require a larger incision for specimen extraction, and obese patients are at an increased risk of developing SSI. In this aspect, TVSE is also useful for obese patients.
Complications of TVSE are reportedly infrequent [9, 10], but the risk of infection due to the transvaginal maneuvers is of concern. In our department, we irrigate the vagina and abdominal cavity with saline before and after extraction, and an Alexis® wound retractor and tissue collection bags are used for specimen extraction so as to protect the vagina and help prevent infections. We have not experienced any infections using TVSE in any of our other cases, including cases of colon, stomach, and liver cancer, as well as cancer of the small intestine. It is extremely important to ensure oncological suitability. No relapse specifically caused by TVSE has been reported for colon cancer [9, 12]; however, some reports have pointed out that to prevent peritoneal dissemination or delivery site metastasis, specimens should be put in a bag before extraction . However, others claim that as long as oncological principles and procedures are followed, there should be no increase in the dissemination as a result of TVSE, and the validity of TVSE in early-stage uterine cervical cancer has been demonstrated in the field of gynecology . In this case, the specimen was put in a collection bag for extraction. We also fragmented the spleen inside the bag for easier extraction. With this method, the extraction of larger solid organ specimens by TVSE is at least theoretically possible as long as there are no pathological problems.
In our department, we have performed NOSE mainly for colon cancer surgery. Some studies show that NOSE for colorectal cancer is feasible, safe, and oncologically acceptable for selected cases [13, 14]. TVSE enables us to extract relatively large specimens, the vagina being very elastic. TVSE is potentially adaptable to all types of abdominal carcinomas. TVSE being a technique under development, we generally perform TVSE only for carcinomas diagnosed in the absence of lymph node metastasis and serosa infiltration.
We describe a case of splenic metastasis of ovarian cancer for which a complete laparoscopic splenectomy was performed in the supine position, with transvaginal specimen extraction. We eliminated the disadvantage of the lateral position using the supine position. Additionally, TVSE reduced the damage to the body wall, allowing an extremely minimally invasive operation. TVSE may become an option for even less invasive laparoscopic surgeries in the future.
Written informed consent was obtained from the patient for the publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
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