A case study of a collision tumor composed of cancers of the bile duct and pancreas
© Izumi et al.; licensee Springer. 2015
Received: 5 January 2015
Accepted: 22 April 2015
Published: 9 May 2015
In this case report, we describe the extremely rare case of a collision tumor comprising cancers of the bile duct and the pancreas. A 70-year-old man was referred to our hospital with a diagnosis of obstructive jaundice. He was diagnosed with pancreatic head cancer, and we performed a pancreaticoduodenectomy with lymph node dissection. At laparotomy, there were two palpable masses in the vicinity of the confluence of the cystic duct and the head of the pancreas. The resected specimen demonstrated tumors at the confluence of the cystic duct and in the pancreatic head. Histopathological examination demonstrated a moderately differentiated tubular adenocarcinoma in the pancreatic head and a well-differentiated tubular adenocarcinoma at the confluence of the cystic duct. Immunostaining was negative for p53 and MUC6 in the pancreatic head tumor; however, immunostaining was positive for both in the tumor located at the confluence of the cystic duct. The two tumors were histologically different and were diagnosed as collision cancer caused by the collision of the bile duct and pancreatic cancers.
KeywordsCollision tumor Bile duct cancer Pancreatic cancer
Collision cancers are malignancies in the same organ or anatomical site that comprises at least two different tumor components, with no mixed or transitional area between two components. Dual cancer involving a combination of pancreatic and bile duct cancers is rare, and to our knowledge, few cases of a collision cancer composed of these two specific cancers have been previously reported . We encountered a patient with a very rare collision cancer in which the pancreatic and bile duct cancers had collided.
Patient was a 70-year-old male.
Chief complaint was right upper abdominal pain.
Past medical history
Past medical history was unremarkable.
Family medical history
Family medical history was unremarkable.
History of present illness
The patient presented to his physician with a chief complaint of right upper abdominal pain in November 2009. Blood testing demonstrated obstructive jaundice, and the patient was admitted to our hospital for further evaluation.
Relevant physical exam
The palpebral conjunctivae were mildly yellow, but no pallor was noted. The abdomen was flat and soft without tenderness, and no mass was palpated.
Laboratory data on admission
8.4 × 103/μL
4.56 × 106/μL
18.9 × 104/μL
An approximately 3-cm, low-echoic mass with unclear boundaries and heterogeneous content was detected in the pancreatic head. There was a 17.8-mm dilation of the common bile duct and a 2.9-mm dilation of the caudal pancreatic duct due to the mass.
Abdominal computed tomography
Magnetic resonance cholangiopancreatography
The intrapancreatic bile duct tapered off sharply, and there was marked dilation of the duct proximal to this obstruction.
Endoscopic retrograde cholangiopancreatography
At laparotomy, the abdomen was opened using an upper abdominal midline incision. No ascites or peritoneal seeding was noted. There were two palpable masses in the vicinity of the confluence of the cystic duct and the head of the pancreas. The resected margins of the pancreatic and biliary ducts were subjected to rapid intraoperative pathological examination, and the bile duct remnant was found to be positive for residual tumor cells. After additional resection, rapid intraoperative pathological examination confirmed clear margins. Pylorus-preserving pancreaticoduodenectomy and lymph node dissection were performed.
Gemcitabine chemotherapy was administered as adjuvant chemotherapy following standard treatment guidelines for pancreatic cancer. However, the patient died of multiple lung metastases 4 years and 1 month after surgery.
According to the criteria presented by Warren and Gates , synchronous malignant neoplasms are defined as follows: (1) each of the tumors must present a definite picture of malignancy; (2) each must be distinct; and (3) the possibility that one is a metastatic lesion caused by the other must be ruled out. Also, Moertel et al.  arbitrarily classified tumors diagnosed within a 6-month period as ‘simultaneous lesions’ and those diagnosed at intervals of longer than 6 months as ‘interval lesions.’
The number of reports of dual cancers is increasing every year due to the marked progress of diagnostic imaging technology in recent years, increasing frequency of medical checkups, and the aging of the population [4-6]. The reported rate of pancreatic cancer associated with other organ malignancies is 5.6% to 16.6% [7,8]. The ranking of cancers presenting concomitantly with pancreatic cancer, from the highest to the lowest incidence, is as follows: gastric cancer, thyroid cancer, lung cancer, and breast cancer.
Collision cancers refer to tumors located in the same organ or anatomical site. According to the World Health Organization (WHO) histological classification, collision tumors comprise at least two different malignant components, with no mixed or transitional area in between. Among intrapancreatic collision tumors, the incidence of collision between an intraductal papillary mucinous neoplasm and cancers of other types is high [9,10]. In the pancreatic head area, adenocarcinoma and other types of cancer have been reported; however, collision of two adenocarcinomas is extremely rare. To the best of our knowledge, this is the third reported case of a collision tumor between a bile duct adenocarcinoma and pancreatic adenocarcinoma.
The symptoms and imaging-based findings of pancreatic head cancer accompanied by bile duct infiltration are very similar to those of bile duct cancer accompanied by pancreatic infiltration, and it is difficult to distinguish between these two conditions before surgery in many cases. In our patient, a mass was palpated in the pancreatic head during surgery, and a hard, hypertrophic bile duct was also palpated at the confluence of the three ducts slightly distal to the pancreatic mass. In the resected specimen, a mass was also observed at the confluence of the three ducts slightly proximal to the mass in the pancreatic head, suggesting dual cancer. Obstructive jaundice associated with pancreatic head cancer is generally assumed to result from malignant invasion of the bile duct by the pancreatic cancer. However, in this patient, the stenosis of the ducts within the head of the pancreas and the hypertrophy of the bile duct at the confluence of the three ducts were slightly separated from each other. Thus, it is possible that this particular dual cancer might have been diagnosed earlier if endoscopic ultrasonography or intraductal ultrasonography had been performed.
The clinical behavior, associated prognosis, and malignant potential of collision tumors are generally related to the most aggressive of the colliding tumors . Pancreatic carcinoma is associated with a very poor prognosis and a short survival period. Therefore, the prognosis of patients with dual cancers involving pancreatic cancer mainly depends on the prognosis associated with the pancreatic cancer . On the other hand, Geng Ming Niu et al.  reported ten cases of collision cancer in which the colliding cancers were pancreatic and periampullary cancers, and the outcome was worse than that of patients with pancreatic cancer alone.
In reports of collision cancers in which periampullary carcinoids and adenocarcinomas collided, the difference in the origins of the tumors was observed on CEA staining [12,13]. Hirono et al.  also reported differences among the CK20, MUC2, and p53 expression levels on immunostaining of cancers presenting in the bile duct and the ampulla of Vater, showing that they were independent cancers colliding with each other rather than one type of cancer. In our patient, differences were noted in the expression levels of p53 and MUC6, showing that two histopathologically different cancers had collided with each other in the pancreatic parenchyma. No transition between the two cancers was noted, leading to a diagnosis of collision cancer composed of bile duct and pancreatic cancers.
The pathological and immunohistochemical findings in this case support the assertion that two separate cancers, one originating from the bile duct and one from the head of the pancreas, collided with each other, and thus, this case can be defined as one of collision cancers. Our case report is the third report of a case of collision cancer between a bile duct cancer and a pancreatic cancer.
Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the editor in chief of this journal.
The authors would like to thank Enago for the English language review.
- Niu G, Jin D, Ji Y, Hou J, Wang D, Lou W. Survival analysis of pancreatic and periampullary collision cancers. J Dig Dis. 2010;11:231–6.PubMedGoogle Scholar
- Warren S, Gates O. Multiple primary malignant tumors. A survey of the literature and a statistical study. Am J Cancer. 1932;16:1358–414.Google Scholar
- Moertel CG, Dockerty MB, Baggenstoss AH. Multiple primary malignant neoplasms. Cancer. 1961;14:221–30.View ArticlePubMedGoogle Scholar
- Shimizu S, Oshita A, Tashiro H, Amano H, Kobayashi T, Tanaka M, et al. Synchronous double cancers of primary hepatic adenosquamous carcinoma and hepatocellular carcinoma: report of a case. Surg Today. 2013;43:418–23.View ArticlePubMedGoogle Scholar
- Haratake J, Hashimoto H. An immunohistochemical analysis of 13 cases with combined hepatocellular and cholangiocellular carcinoma. Liver. 1995;15:9–15.View ArticlePubMedGoogle Scholar
- Miyaguni T, Muto Y, Kusano T, Yamada M, Matsumoto M, Shiraishi M. Synchronous double cancers of the remnant stomach and pancreas: report of a case. Surg Today. 1995;25:1038–42.View ArticlePubMedGoogle Scholar
- Kamisawa TIT, Egawa N, Tsuruta K, Okamoto A, Kawamura T, Koike M. Study on pancreatic cancer associated with other primary malignancies (in Japan). Suizo (J Jpn Pancr Soc). 1993:164–9.Google Scholar
- Makino TKY, Takahashi S, Maruyama H, Kohara T, Yokose Y, Emi Y, et al. Clinicopathology of pancreatic cancer analyzed from annual of the pathological autopsy cases in Japan (in Japanese). Tan To Sui (J Gall Pancr). 1984:761–8.Google Scholar
- Hirono S, Tani M, Terasawa H, Kawai M, Ina S, Uchiyama K, et al. A collision tumor composed of cancers of the bile duct and ampulla of Vater - immunohistochemical analysis of a rare entity of double cancer. Hepatogastroenterology. 2008;55:861–4.PubMedGoogle Scholar
- Stukavec J, Jirasek T, Mandys V, Denemark L, Havluj L, Sosna B, et al. Poorly differentiated endocrine carcinoma and intraductal papillary-mucinous neoplasm of the pancreas: description of an unusual case. Pathol Res Pract. 2007;203:879–84.View ArticlePubMedGoogle Scholar
- Eriguchi N, Aoyagi S, Hara M, Okuda K, Tamae T, Fukuda S, et al. Synchronous or metachronous double cancers of the pancreas and other organs: report on 12 cases. Surg Today. 2000;30(8):718–21.View ArticlePubMedGoogle Scholar
- Williams IM, Williams NW, Stock D, Foster ME. Collision tumour of the ampulla of Vater: carcinoid and adenocarcinoma. HPB Surg. 1997;10:241–4.View ArticlePubMed CentralPubMedGoogle Scholar
- Ferrando Marco J, Pallas Regueira A, Moro Valdezate D, Fernández Martínez C. Collision tumor of the ampulla of Vater: carcinoid and adenocarcinoma. Rev Esp Enferm Dig. 2007;99:235–8.View ArticlePubMedGoogle Scholar
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.