Simultaneous pulmonary metastases from colon and prostate cancer to the same lobe
© Nakamura; licensee Springer. 2015
Received: 2 February 2015
Accepted: 16 March 2015
Published: 31 March 2015
Simultaneous pulmonary metastases from different primary tumors to the same lobe are extremely rare, and we herein report the case. Surgical specimen of the pulmonary metastasis from colon cancer contained two additional nodules that were confirmed as metastases from prostate cancer. Pulmonary metastasis from prostate cancer rarely forms nodules, and there is a discrepancy in the incidence of pulmonary metastases between autopsy and clinical findings. This case suggests that different malignant tumors could simultaneously metastasize to the same pulmonary lobe, and more pulmonary metastases from prostate cancer might exist than expected.
Pulmonary metastasectomy plays an important role in selected patients and is widely performed, especially in colorectal cancer patients. However, simultaneous pulmonary metastasis from another primary organ is very rare. We experienced a case of simultaneous metastases from colon and prostate cancer and herein report the case.
Antiandrogen therapy was continued without any cytotoxic therapy for colon cancer. He died of acute cardiac failure 2 years after pulmonary lobectomy with undetectable serum PSA level (<0.1 ng/ml). Autopsy imaging showed no sign of recurrence.
The present case revealed simultaneous pulmonary metastases from colon and prostate cancer in the same lobe. Although a case of primary lung cancer with metastatic lymph node from prostate cancer has been reported, simultaneous pulmonary metastases from colorectal and prostate cancer are uncommon .
Surgical resection of a metastatic lung tumor is a feasible treatment option, especially in colorectal cancer patients. In contrast, the clinical significance of pulmonary metastasectomy in prostate cancer has not been established. This is because most pulmonary metastases from prostate cancer reveal lymphangitic spread, not nodules as in the present case, and are usually concomitant with bone metastases. While bone metastasis is the most frequent dissemination and a prognostic factor in prostate cancer, pulmonary metastasis is less frequent and has no impact on survival because of high sensitivity to endocrine therapy [2,3]. Because of these findings, clinical significance of pulmonary metastasectomy from prostate cancer is not established .
Although pulmonary metastases from prostate cancer account for 23% to 63% in autopsy series [2,5-7], only 3.6% to 21.2% of them are clinically evident [3,8,9]. These data suggest that more pulmonary metastases from prostate cancer might exist than expected and tend to be overlooked clinically. In the present case, the metastases were overlooked before surgery, in spite of the visualization on CT retrospectively (Figure 1B).
To the best of our knowledge, this is the first report that simultaneous pulmonary metastases from colon and prostate cancer occurs to the same lobe. Thoracic surgeons should be aware of this rare condition and that more pulmonary metastases from prostate cancer might exist than expected.
We routinely obtained general consent from every patient for using their clinical data before surgery. Written informed consent was not obtained from the patient for publication of this case report because this report is just a retrospective case report without additional invasive examinations or treatments for the study.
- Rossi G, Nannini N, Casali C, Longo L, Mengoli MC, Cavazza A. Peribronchial lymph node metastasis from prostate cancer in pulmonary lobectomy for primary lung adenocarcinomas: a possible source of pitfall with therapeutic consequences. Histopathology. 2011;58(6):996–8. doi:10.1111/j.1365-2559.2011.03841.x.View ArticlePubMedGoogle Scholar
- Nakamachi H, Suzuki H, Akakura K, Imamoto T, Ueda T, Ishihara M, et al. Clinical significance of pulmonary metastases in stage D2 prostate cancer patients. Prostate Cancer Prostatic Dis. 2002;5(2):159–63. doi:10.1038/sj.pcan.4500573.View ArticlePubMedGoogle Scholar
- Fabozzi SJ, Schellhammer PF, El-Mahdi AM. Pulmonary metastases from prostate cancer. Cancer. 1995;75(11):2706–9.View ArticlePubMedGoogle Scholar
- Wallis CJ, English JC, Goldenberg SL. The role of resection of pulmonary metastases from prostate cancer: a case report and literature review. Canadian Urological Association J. 2011;5(6):E104–8. doi:10.5489/cuaj.10136.View ArticleGoogle Scholar
- Legge DA, Good CA, Ludwig J. Roentgenologic features of pulmonary carcinomatosis from carcinoma of the prostate. Am J Roentgenol Radium Ther Nucl Med. 1971;111(2):360–4.View ArticlePubMedGoogle Scholar
- Bubendorf L, Schopfer A, Wagner U, Sauter G, Moch H, Willi N, et al. Metastatic patterns of prostate cancer: an autopsy study of 1,589 patients. Hum Pathol. 2000;31(5):578–83.View ArticlePubMedGoogle Scholar
- Saitoh H, Hida M, Shimbo T, Nakamura K, Yamagata J, Satoh T. Metastatic patterns of prostatic cancer. Correlation between sites and number of organs involved Cancer. 1984;54(12):3078–84.Google Scholar
- Bolton BH. Pulmonary metastases from carcinoma of the prostate: incidence and case report of a long remission. J Urol. 1965;94:73–7.PubMedGoogle Scholar
- Varkarakis MJ, Winterberger AR, Gaeta J, Moore RH, Murphy GP. Lung metastases in prostatic carcinoma. Clinical significance. Urology. 1974;3(4):447–52.View ArticlePubMedGoogle Scholar
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