- Case report
- Open Access
A large mural nodule in branch duct intraductal papillary mucinous adenoma of the pancreas: a case report
© Haruki et al.; licensee Springer. 2015
- Received: 24 October 2014
- Accepted: 8 December 2014
- Published: 24 February 2015
Indications for resection of branch duct intraductal papillary mucinous neoplasms (IPMNs) remain controversial because of their low tendency to be malignant. Surgical resection should be recommended if any factors indicating malignancy are present. However, preoperative differentiation between benign and malignant tumors is very difficult, especially in cases of branch duct IPMNs. We herein report a case of branch duct intraductal papillary mucinous adenoma (IPMA) of the pancreas with a large mural nodule of 25 mm. A 74-year-old woman was admitted for examination and treatment for a cystic tumor in the head of the pancreas. Magnetic resonance cholangiopancreatography and computed tomography showed a cystic lesion, 50 mm in diameter, with an irregular mural nodule in the pancreatic head. Endoscopic ultrasonography demonstrated a multicystic tumor connected with the main pancreatic duct (MPD). The mural nodule had a diameter of 18 mm, and the MPD had a slight dilation of 6 mm. These findings suggested a high potential for malignancy. The patient underwent pancreaticoduodenectomy with lymph node dissection. The excised pancreas showed multiple cysts located in the branch pancreatic duct with a maximum diameter of 75 mm. The mural nodule had a maximum diameter of 25 mm. The tumor was diagnosed as an IPMA by pathological examination. After operation, the patient was discharged without any complications. Two years after resection, the patient remains in remission with no evidence of tumor recurrence.
- Intraductal papillary mucinous neoplasm
- Branch duct
- Mural nodule
Detection of intraductal papillary mucinous neoplasms (IPMNs) of the pancreas has been increasing due to recent advances in imaging. IPMNs can be malignant and undergo transformation from an adenoma to invasive carcinoma. International consensus guidelines from 2006  and recently updated in 2012  recommend surgical resection of main duct IPMNs due to a high risk of malignancy, ranging from 60% to 100%. On the other hand, branch duct IPMNs have lower rate of malignancy (6% to 51%) [3-5], although surgical resection should be recommended if any factors indicating malignancy are present. Large mural nodules are associated with a higher risk of malignancy. However, differentiating between intraductal papillary mucinous adenoma (IPMA) and intraductal papillary mucinous carcinoma (IPMC) is often difficult, especially in branch duct IPMNs. We herein report a case of branch duct IPMA of the pancreas with a large mural nodule. To the best of our knowledge, this case involves the largest mural nodule diagnosed as branch duct IPMA reported so far in the English literature.
IPMNs are an increasingly recognized entity representing a spectrum of benign and malignant neoplasms of the pancreas. While there is a general consensus that all main duct IPMNs should be resected, the indications for resection of branch duct IPMNs remain controversial because of their lower tendency for malignancy. The guidelines include a flowchart covering the suggested surgical resection and follow-up procedures for branch duct IPMNs. Recent guidelines  recommended that surgical resection should be considered without further testing if a patient with a cystic lesion of the pancreas has obstructive jaundice, an enhancing solid component within the cyst, or dilation of the MPD to ≥10 mm. According to the most recent guidelines, surgical resection was therefore required in this case due to the presence of an enhanced mural nodule. Moreover, older guidelines  recommended that resection should be performed if any of the following five factors are present: a cyst >3 cm in diameter, mural nodules, MPD dilation to >6 mm, positive cytology, or symptoms attributable to the tumor. Nagai et al.  evaluated the usefulness of these guidelines in branch duct IPMN and reported a high sensitivity (97.3%) but low specificity (29.8%) for predicting malignancy in branch duct IPMN according to these guidelines. Furthermore, as patients presented with more factors, there was an increase in the specificity and positive predictive value but a decrease in sensitivity and negative value of the guidelines for making a preoperative diagnosis of malignancy. Although preoperative imaging, such as EUS and MRCP, showed that the case presented here had four of the factors described in the previous guidelines, histology indicated that the tumor was an IPMA.
Some meta-analyses have evaluated the risk of malignancy. For both main duct and branch duct IPMNs, a cyst size >3 cm, presence of a mural nodule, MPD dilation, and main duct IPMNs were associated with an increased risk of malignancy . For branch duct IPMNs, presence of a mural nodule, MPD dilation, thick septum/wall, and a cyst size >3 cm were indicators of malignancy .
Several recent studies reported that the size of mural nodules was a more significant malignant factor than tumor size for predicting the malignancy of branch duct IPMNs. For the prediction, the cutoff values for mural nodule size were 5 to 10 mm [9-12]. In addition, the MPD size, high serum CEA and carbohydrate antigen 19–9 levels, and high CEA levels in the pancreatic juice have been reported to be predictive factors for malignancy of branch duct IPMNs [11,13,14]. However, it is still impossible to detect all malignant cases, even after examination for these factors and the use of recent imaging modalities. EUS is very useful for identifying small lesions in the pancreas and a helpful modality for the diagnostic evaluation of branch duct IPMNs [12,15]. Furthermore, the mural nodule size of branch duct IPMNs detected using EUS was a reliable predictive factor for malignancy . Magnetic resonance imaging is also well suited for the detection of pancreatic lesions, including IPMNs . There have also been meta-analyses on these tools for differentiating malignant and benign IPMNs. Cytology based on endoscopic retrograde cholangiopancreatography was reported to have a high specificity (97.2%) but a poor sensitivity (35.1%) for distinguishing benign IPMNs from malignant IPMNs . The level of cyst fluid CEA was mostly ineffective in differentiating malignancy; sensitivity was 65%, while specificity was 66% . In histology, expression of human telomerase reverse transcriptase was strongly associated with malignant transformation in IPMNs .
Preoperative prediction of malignancy for branch duct IPMNs is still difficult. Therefore, further studies, including advances in high-resolution imaging or improved molecular-biological techniques, would be required for correct and differential diagnosis of IPMA and IPMC.
Written informed consent was obtained from the patients for publication of this case report and any accompanying images.
- Tanaka M, Chari S, Adsay V, Fernandez-del Castillo C, Falconi M, Shimizu M, et al. International consensus guidelines for management of intraductal papillary mucinous neoplasms and mucinous cystic neoplasms of the pancreas. Pancreatology. 2006;6:17–32.View ArticlePubMedGoogle Scholar
- Tanaka M, Fernández-del Castillo C, Adsay V, Chari S, Falconi M, Jang JY, et al. International consensus guidelines 2012 for the management of IPMN and MCN of the pancreas. Pancreatology. 2012;12:183–97.View ArticlePubMedGoogle Scholar
- Nagai K, Doi R, Kida A, Kami K, Kawaguchi Y, Ito T, et al. Intraductal papillary mucinous neoplasms of the pancreas: clinicopathologic characteristics and long-term follow-up after resection. World J Surg. 2008;32:271–8.View ArticlePubMedGoogle Scholar
- Matsumoto T, Aramaki M, Yada K, Hirano S, Himeno Y, Shibata K, et al. Optimal management of the branch duct type intraductal papillary mucinous neoplasms of the pancreas. J Clin Gastroenterol. 2003;36:261–5.View ArticlePubMedGoogle Scholar
- Sugiyama M, Izumisato Y, Abe N, Masaki T, Mori T, Atomi Y. Predictive factors for malignancy in intraductal papillary-mucinous tumours of the pancreas. Br J Surg. 2003;90:1244–9.View ArticlePubMedGoogle Scholar
- Nagai K, Doi R, Ito T, Kida A, Koizumi M, Masui T, et al. Single-institution validation of the international consensus guidelines for treatment of branch duct intraductal papillary mucinous neoplasms of the pancreas. J Hepatobiliary Pancreat Surg. 2009;16:353–8.View ArticlePubMedGoogle Scholar
- Anand N, Sampath K, Wu BU. Cyst features and risk of malignancy in intraductal papillary mucinous neoplasms of the pancreas: a meta-analysis. Clin Gastroenterol Hepatol. 2013;11:913–21.View ArticlePubMedGoogle Scholar
- Kim KW, Park SH, Pyo J, Yoon SH, Byun JH, Lee MG, et al. Imaging features to distinguish malignant and benign branch-duct type intraductal papillary mucinous neoplasms of the pancreas: a meta-analysis. Ann Surg. 2014;259:72–81.View ArticlePubMedGoogle Scholar
- Uehara H, Ishikawa O, Katayama K, Kawada N, Ikezawa K, Fukutake N, et al. Size of mural nodule as an indicator of surgery for branch duct intraductal papillary mucinous neoplasm of the pancreas during follow-up. J Gastroenterol. 2011;46:657–63.View ArticlePubMedGoogle Scholar
- Kanno A, Satoh K, Hirota M, Hamada S, Umino J, Itoh H, et al. Prediction of invasive carcinoma in branch type intraductal papillary mucinous neoplasms of the pancreas. J Gastroenterol. 2010;45:952–9.View ArticlePubMedGoogle Scholar
- Hirono S, Tani M, Kawai M, Okada K, Miyazawa M, Shimizu A, et al. The carcinoembryonic antigen level in pancreatic juice and mural nodule size are predictors of malignancy for branch duct type intraductal papillary mucinous neoplasms of the pancreas. Ann Surg. 2012;255:517–22.View ArticlePubMedGoogle Scholar
- Kobayashi N, Sugimori K, Shimamura T, Hosono K, Watanabe S, Kato S, et al. Endoscopic ultrasonographic findings predict the risk of carcinoma in branch duct intraductal papillary mucinous neoplasms of the pancreas. Pancreatology. 2012;12:141–5.View ArticlePubMedGoogle Scholar
- Zhang HM, Yao F, Liu GF, Wang XB, Xiu DH, Gen I. The differences in imaging features of malignant and benign branch duct type of Intraductal Papillary Mucinous Tumor. Eur J Radiol. 2011;80:744–8.View ArticlePubMedGoogle Scholar
- Akita H, Takeda Y, Hoshino H, Wada H, Kobayashi S, Marubashi S, et al. Mural nodule in branch duct-type intraductal papillary mucinous neoplasms of the pancreas is a marker of malignant transformation and indication for surgery. Am J Surg. 2011;202:214–9.View ArticlePubMedGoogle Scholar
- Wong J, Weber J, Centeno BA, Vignesh S, Harris CL, Klapman JB, et al. High-grade dysplasia and adenocarcinoma are frequent in side-branch intraductal papillary mucinous neoplasm measuring less than 3 cm on endoscopic ultrasound. J Gastrointest Surg. 2013;17:78–84.View ArticlePubMedGoogle Scholar
- Canto MI, Hruban RH, Fishman EK, Kamel IR, Schulick R, Zhang Z, et al. Frequent detection of pancreatic lesions in asymptomatic high-risk individuals. Gastroenterology. 2012;142:796–804.View ArticlePubMed CentralPubMedGoogle Scholar
- Suzuki R, Thosani N, Annangi S, Komarraju A, Irisawa A, Ohira H, et al. Diagnostic yield of endoscopic retrograde cholangiopancreatography-based cytology for distinguishing malignant and benign intraductal papillary mucinous neoplasm: systematic review and meta-analysis. Dig Endosc. 2014;26:586–93.View ArticlePubMedGoogle Scholar
- Ngamruengphong S, Bartel MJ, Raimondo M. Cyst carcinoembryonic antigen in differentiating pancreatic cysts: a meta-analysis. Dig Liver Dis. 2013;45:920–6.View ArticlePubMedGoogle Scholar
- Nissim S, Idos GE, Wu B. Genetic markers of malignant transformation in intraductal papillary mucinous neoplasm of the pancreas: a meta-analysis. Pancreas. 2012;41:1195–205.View ArticlePubMedGoogle Scholar
- Kawada N, Uehara H, Nagata S, Tsuchishima M, Tsutsumi M, Tomita Y. Predictors of malignancy in branch duct intraductal papillary mucinous neoplasm of the pancreas. JOP. 2014;15:459–64.PubMedGoogle Scholar
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.