Treatment of bleeding from a portion of pancreatojejunostomy after pancreaticoduodenectomy with division of the splenic vein: two case reports

Background There is no definitive strategy for gastrointestinal bleeding due to left-sided portal hypertension after pancreaticoduodenectomy (PD) for pancreatic cancer (PC) with concomitant portal vein resection (PVR). Case presentation Case 1: A 70-year-old woman underwent a PD for PC with PVR. Seven years after her surgery, she suffered severe anemia with suspected gastrointestinal bleeding. Computed tomography scan (CT) revealed varices at a portion of the pancreaticojejunostomy (PJ). Angiography revealed that splenic venous flow drained into the varices and then into the portal vein. A diagnosis of bleeding varices of the PJ due to left-sided portal hypertension was made. Following a partial splenic artery embolization, her anemia improved. Case 2: An 80-year-old male underwent a PD for pancreatic head cancer combined with resection of the confluence of the portal and splenic veins with a reconstruction between the portal and superior mesenteric veins. Eighteen months after his surgery, he developed melena with negative endoscopy findings in his large and small bowel. CT revealed varices at the site of the PJ that communicated with the jejunal and portal veins. He underwent obliteration of the varices via a trans-portal-venous approach. As a result, he remained without melena until he died of PC 17 months after the embolization. Conclusions Left-sided portal hypertension following a PD with bleeding varices can be treated by interventional radiology with minimal invasiveness.


Background
Left-sided portal hypertension (LSPH) is a localized form of portal hypertension that occurs as a result of an isolated thrombosis or obstruction of the splenic vein (SV) [1]. LSPH is different from PH in terms of normal liver function and no obstruction of the portal vein (PV) [2]. Also, it has been reported that LSPH occurred after pancreaticoduodenectomies (PDs) without SV reconstructions [3,4]. Herein, we discuss two different types of interventional radiology (IVR) methods for treating intestinal bleeding from pancreaticojejunostomies (PJs) due to LSPH after PDs with concomitant PV resections (PVRs).

Case 1
A 70-year-old woman underwent PD for pancreatic cancer (PC) with a concomitant PVR. She also underwent an SV and inferior mesenteric vein (IMV) resection. The side-to-end anastomosis was performed only between the SV and IMV (Fig. 1). She discharged without complications. Seven years after her surgery, she suffered severe anemia and gastrointestinal bleeding was suspected. However, we could not find a bleeding lesion using gastrointestinal endoscopes. Computed tomography (CT) revealed varices at a portion of the PJ (Fig. 2a, b). Angiography revealed that splenic venous flow drained into the varices around the PJ and then ran into the PV (Fig. 2c). Therefore, we diagnosed that her anemia originated from varices at the PJ with LSPH.
We selected partial splenic artery embolization (PSE) for hemostasis. At the first stage, we embolized 70% of the splenic arterial flow. Ten months after the first stage PSE, she again complained of melena and anemia, for which we performed a second stage PSE (embolized 90% of splenic artery flow). Although follow-up CT at 3 years after first stage PSE showed the varices around the PJ (Fig. 3), her bleeding episodes have not been observed during a 2-year follow-up period.

Case 2
An 80-year-old male underwent a PD for pancreatic head cancer combined with resection of the confluence  of the PV and SV in addition to a reconstruction between the PV and superior mesenteric vein (SMV) (Fig. 4). Eighteen months after surgery, he had melena with negative findings on both upper and lower gastrointestinal endoscopic examinations. CT scans revealed varices at a portion of the PJ that communicated with a vein of the elevated jejunal limb and the PV (Fig. 5a, b). We selected obliteration of the varices via a trans-portal-venous approach by puncturing the intrahepatic PV. The varices around the PJ disappeared after obliteration using ethanolamine oleate iopamidol (Fig. 5c, d). Follow-up CT at 1 year after this procedure showed no varices at a portion of the PJ (Fig. 6). His melena had disappeared until his death due to a recurrence of PC 17 months after IVR.

Discussion
Previously, some authors have shown that PD without SV reconstruction could cause LSPH [3,4]. However, until now, there was no definitive procedure to prevent LSPH after PVR without SV reconstruction because certain LSPH mechanisms after a PD were unclear. Gyoten  et al. [5] reported that concomitant splenic artery divisions during operations may attenuate the risk of LSPH. Some authors [6,7] also advocated that preserving the SV-IMV confluence or reconstruction of the SV-IMV anastomosis would be useful for preventing LSPH. However, Ono [8] and Ismael et al. [9] showed that SV-IMV anastomosis or SV-IMV confluence preservation was insufficient because blood flow from the SV eventually drains into the SMV via the marginal veins of the colon and/or omentum. Findings of our cases support their findings. The present cases showed that preservation of the SV-IMV flow was not useful in preventing LSPH. One possible reason for the formation of varices at a portion of the PJ is the division of communication from the SV to the greater omentum and marginal veins of the transverse and right colon. Because we usually separate the omentum from the colon when we perform a PD, our experiences supported Ono and Ismael's opinions. Recently, some authors [10,11] have shown that the preservation of collateral veins prevents LSPH. Considering these findings, preservation of many drainage vein of splenic flow may reduce the risk of LSPH. For intestinal bleeding from a PJ due to LSPH, several types of procedures can be considered: total pancreatectomy, a splenectomy, obliteration of the varices via a trans-portal-venous approach, and a PSE. Previously, several authors have reported that PSE is an effective treatment for acute gastric bleeding due to LSPH [12,13]. Our first case suggested that PSE would be effective not only for gastric bleeding but also for bleeding from PJs due to LSPHs. PSEs are also thought to be less invasive than splenectomies. However, PSEs could cause severe postoperative reactions such as splenic abscess, sepsis, and splenic ruptures [14]. Wang et al. [15] reported that splenic infarctions following PSEs could be controlled in 60-70% of patients. However, some recent reports have indicated that a total splenic embolization may be associated with lower rates of splenic abscess formation than partial embolization [16,17].
In our second case, we selected obliteration of the varices at the PJ via a trans-portal-venous approach because CT scans showed a route from the PV to the varices at a portion of the PJ. This procedure was previously reported by Sakamoto et al. [18] in 2014. This procedure had several benefits that could maintain the splenic arterial flow and approach the varices directly. However, the procedure is highly technical. In our first case, we cannot select obliteration of the varices because the approach to the varices from PV was thought to be difficult due to tortuosity of the vein.
Our cases suggested that IVR could be the first choice for intestinal bleeding at a portion of the PJ due to LSPH. Furthermore, it is assumed that trans-portal-venous approach is first-choice procedure.

Conclusions
We presented two types of IVR procedures for intestinal bleeding at a portion of the PJ following PD. The obliteration of the varices in PJ could be first choice procedure.