Table 1 Conversion surgery after PRRT for initially unresectable PNET
Case | Year | Authors | Age | Sex | Liver metastasis | Unresectable factors | Pre-treatment | Response (RECIST) | Conversion surgery | R | PFS months |
|---|---|---|---|---|---|---|---|---|---|---|---|
1 | 2009 | Kaemmerer [31] | 33 | F | No | SMA/SMV involvement PALN metastasis | 90Y-DOTATATE × 2cycles | PR | PPPD + Mesenterium LN resection | R0 | 18.0 |
2 | 2010 | Stoeltzing [19] | 49 | M | Yes | Multiple liver metastases | Distal pancreatectomy → 90Y-DOTATOC × 2cycles | PR | Subsegmentectomy + RFA | R0 | 12.0 |
3 | 2012 | Ezziddin [32] | 43 | F | Yes | SMV involvement Multiple liver metastases | 177Lu-DOTATATE × 3cycles | PR-CR | PD + adjuvant SSA | R0 | 22.0 |
4 | 2012 | Barber [33] | 50 | M | No | Not mentioned | Chemotherapy → 177Lu-DOTATATE × 4cycles | PR | Not mentioned | R0 | 12.0 |
5 | 2020 | Chiapponi [20] | 49 | M | Yes | Multiple liver metastases | Sandostatin + 177Lu-DOTATATE → Selective internal radiotherapy | PR | Distal pancreatectomy + Partial hepatectomy | R1 | 57.0* |
6 | 2021 | Opalinska [21] | – | M | No | Large vessel infiltration or Invasion to adjacent organs | 90Y-DOTATATE¶ | PD | Not mentioned | R1 | 8.2 |
7 | 2021 | Opalinska [21] | – | M | Yes | 177Lu/90Y-DOTATATE¶ | SD | Hemi-hepatectomy | R0 | 116.2 | |
8 | 2021 | Opalinska21 | – | F | Yes | 90Y-DOTATATE¶ | SD | Not mentioned | R0 | 26.4 | |
9 | 2023 | Our case | 52 | M | Yes | Bone metastasis Multiple liver metastases | SSA → 177Lu-DOTATATE + SSA | PR-CR | Partial hepatectomy | R0 | 17.0 |
10 | 2011 | Staszczak34 | 56 | M | Yes | SMV involvement Multiple liver metastases | 90Y-DOTATATE¶ | PR | Not performed | – | – |