Table 1 Literature review of the reported cases diagnosed with mixed acinar-neuroendocrine carcinoma
Author | Publication date | Age | Symptom | Sex | Size (cm) | Metastasis | Treatment | Regimen of chemotherapy | Follow-up | Recurrence |
|---|---|---|---|---|---|---|---|---|---|---|
Ulich et al | Nov, 1982 | 30 | Epigastric pain | F | 9.3 × 8.6 × 5.8 | None | PD | Alive (4 months) | – | |
Ichijima et al | Jan, 1985 | 6 | – | F | 8 × 5 × 4 | None | Resection | Alive (13 years) | – | |
Hassan et al | Sep-Oct, 1993 | 50 | Weight loss, constipation, abdominal pain | M | 19 × 18 | Liver, multiple | DP + splenectomy + colectomy | Deceased (10 months) | ||
Klimstra et al | Aug, 1994 | 81 | Nausea, abdominal pain | M | 3 | None | Resection | Alive (3 months) | – | |
70 | Back pain | M | 4 × 10 | Liver, lungs, lymph nodes | Resection | Deceased (3 months) | ||||
64 | Hematemesis | F | 10 | None | Bypass (inoperable) | Deceased (18 months) | – | |||
48 | – | F | 11 | Liver | Resection | Alive (12 months) | ||||
79 | Abdominal pain | F | 10 | None | Bypass chemoradiation | N/A | Alive (12 months) | – | ||
Cho et al | Apr, 1996 | 52 | Jaundice | F | 6 × 6 | None | PD + SMV resection | Alive (12 months) | – | |
Shimoike et al | Dec, 1997 | 28 | - | M | 3 | Liver, multiple; vertebral bone | TAE, chemotherapy | STZ, 5-FU | Deceased (10 months) | |
Frank et al | Aug, 1998 | 61 | Uncharacteristic abdominal complaints | M | 4.9 × 3.6 × 2.8 | Liver, later peritoneal carcinomatosis, skin | PD+ left hemihepatectomy + chemotherapy | Octreotide, a-interferon | Deceased (3.5 years) | |
Muramatsu et al | Sep, 2000 | 72 | Appetite loss, weight loss | M | 12 × 13 | Liver, multiple | N/A | Deceased (3 months) | ||
Ogawa et al | Jun, 2000 | 50 | - | M | 3 × 2.5 | None | PD | Alive (18 months) | – | |
Skacel et al | Sep, 2000 | 69 | N/A | M | 10 | None | Resection | Deceased (20 months) | + | |
75 | N/A | M | 5.5 | None | Resection | Alive (10 months) | – | |||
Mizuno et al | May, 2001 | 67 | - | F | N/A | Liver, multiple; at autopsy: spleen, stomach, left ovary, para-aortic lymph nodes | Chemotherapy | Octreotide, diazoxide, 5-FU, doxorubicin | Deceased (7 years) | |
Ohike et al (6 cases) | Jul, 2004 | Mean 58.4 (49–65) | N/A | M:F (2:4) | 8.2 (n = 2) | N/A | N/A | N/A | – | |
Imaoka et al | Oct, 2008 | 80 | N/A | M | 4 | None | PD | N/A | – | |
Kyriazi et al | Apr, 2009 | 74 | - | M | 12 × 9 × 6 | None | PD | Alive (3 months) | – | |
Chung et al | Nov, 2010 | 59 | Watery diarrhea | F | 8 × 2.5 | None | DP + splenectomy | N/A | – | |
Kobayashi et al | Apr, 2010 | 75 | - | M | 7 | None | DP | Alive (6 months) | – | |
Soubra et al | Mar, 2013 | 52 | Epigastric pain, fatigue, jaundice | M | 1.5 × 1.2 × 1.0 | Liver, soft tissue | PD + chemotherapy | 1st: cisplatin, camtothecin 2nd: gemcitabine, cisplatin | Alive (30 months) | |
Lee et al | Feb, 2013 | 66 | Mid-epigastric discomfort | M | 3.1 × 2.8 | Liver | Chemotherapy | Irinotecan, capecitabine, erlotinib, docetaxel | Deceased (21 months) | |
Sullivan et al | April, 2013 | 75 | Acute pancreatitis | M | 0.6 | Liver | Chemotherapy | N/A | N/A | |
51 | - | M | 1.6 | None | DP | N/A | – | |||
Kanemasa et al | Sep, 2013 | 63 | Left flank pain | M | 6 | Liver | Chemotherapy | 1st: S-1 2nd: gemcitabine | Deceased (18 months) | |
Ogbonna et al | Nov, 2013 | 57 | Epigastric pain radiating to the back | F | 2.5 | None | DP + splenectomy + chemoradiation | etoposide,carboplatin | N/A | – |
Yu et al | Apr, 2013 | 80 | Epigastric pain associated with dyspepsia and early satiety | M | 14 × 9 | Liver, kidney | Chemotherapy, palliative surgery | 1st: carboplatin, etoposide 2nd: FOLFOX | Alive (36 months) | |
89 | Poor appetite and weight loss | M | 3.9 × 3.7 | None | PD | Deceased (2.5 months) | – | |||
60 | Abdominal pain, diarrhea | M | 16 × 13 | None | Colectomy, gastrectomy, pancreatectomy, chemotherapy | Cetuximab, irinotecan | Deceased (6 months) | |||
74 | Epigastric pain, weight loss | M | 10 × 5.5 | None | Chemoradiation + DP | neoadjuvant: 5-FU | Alive (17 months) | – | ||
59 | Fatigue, poor appetite, intermittent jaundice | M | 7.5 × 6.5 | None | Whipple | Alive (7 months) | Local recurrence and liver (4 months) | |||
Kumamoto et al | Apr, 2015 | 42 | Back pain | M | 3.1 × 8.0 × 2.9 | Liver, multiple | DP + hepatectomy | Alive (48 months) | 4 months | |
Liu et al | Aug, 2015 | 65 | Jaundice, nagging epigastric pain, intermittent diarrhea | F | 8 × 6 | Liver, multiple | PD + partial hepatectomy | Alive (12 months) | ||
Sugimoto et al | Apr, 2017 | 48 | Abdominal pain | M | 7.7 × 5.9 | None | Chemotherapy + PD | Neoadjuvant: FOLFIRINOX | Alive (21 months) | – |
Takano et al | Oct, 2017 | 50 | Epigastralgia and back pain | M | 3 | None | DP | Alive (1 year) | – | |
Hara et al | Dec, 2017 | 45 | Severe anaemia | F | 11 | Liver, multiple; later, stomach | TACE followed by DP + splenectomy; later gastrectomy | Alive (7 years) | ||
Strait et al | Nov, 2018 | 33 | Abdominal discomfort, back pain, early satiety, weight loss | M | 3.6 × 2.9 | Liver, multiple | Chemotherapy + PD | Neoadjuvant: FOLFIRINOX | Alive (10 months) | |
66 | Abdominal pain | M | 10 | None | Chemotherapy | FOLFIRINOX, panitumumab | Alive (4 months) | – | ||
Tang et al | Jun, 2019 | 52 | Tenderness in the right upper quadrant | M | 10.6 | Liver, multiple | Chemoradiation | Etoposide, cisplatin | Deceased (5 months) | |
Niiya et al | Oct, 2020 | 72 | Upper abdominal pain | M | 2.9 | None | DP | N/A | – | |
Akki et al | Jul, 2021 | 60 s | Abdominal pain | M | 2.2 | None | PD | Alive (31 months) | liver | |
60 s | - | M | 4 | None | DP | Alive (6 months) | - | |||
our case | 65 | – | M | 12 | None | DP + splenectomy + left adrenal, transverse colon, small bowel resection, partial gastrectomy, chemotherapy | 1st: gemcitabine, nab-paclitaxel 2nd: pembrolizumab | Deceased (8 months) | liver, lung, lymph node, peritoneal dissemination (5 months) |