Testicular metastasis 9 years after resection of primary descending colon cancer with simultaneous pulmonary metastasis: a case report

Yoshimura, Daishi; Sekido, Yuki; Takahashi, Hidekazu; Hata, Tsuyoshi; Hamabe, Atsushi; Ogino, Takayuki; Miyoshi, Norikatsu; Uemura, Mamoru; Yamamoto, Hirofumi; Doki, Yuichiro; Eguchi, Hidetoshi

doi:10.1186/s40792-023-01684-x

Surgical Case Reports

Table 1 Summary of heterochronic recurrence of testicular metastasis of colorectal cancer

From: Testicular metastasis 9 years after resection of primary descending colon cancer with simultaneous pulmonary metastasis: a case report

Case Number	Age at primary resection	Time from first surgery to recurrence (months)	Pathological diagnosis of primary lesions			Localization of left and right of primary lesions*	Histological type^†	Primary resection^‡	Adjuvant	Diagnostic indicator of recurrence	Metastasis of peritesticular structures	Treatment	Outcome
Case Number	Age at primary resection	Time from first surgery to recurrence (months)	pT	pN	stage	Localization of left and right of primary lesions*	Histological type^†	Primary resection^‡	Adjuvant	Diagnostic indicator of recurrence	Metastasis of peritesticular structures	Treatment	Outcome
#1 [9]	74	12 M	4	0	II	Right/AC	Tub2	RHC + SBR + OR	+	Scrotal swelling and tenderness	Epididymis, Spermatic cord	Orchiectomy (for pain relief and diagnosis)	Died 2 months after orchiectomy
#2 [10]	64	12 M	3	1	III	Right/TC	Muc	RHC	+	Scrotal swelling	Epididymis, Spermatic cord	Started chemotherapy after right orchiectomy	ND
#3 [11]	51	24 M	ND	ND	ND	Left/DC	Tub2	Colon Resection	−	A small lump in the scrotum that has increased since the primary resection	Peritesticular soft tissue	Started chemotherapy after orchiectomy	ND
#4 [12]	60	8 M	3	2	III	Left/SC	Tub2	AR	+	Scrotal swelling and tenderness	Epididymis	Started chemotherapy	ND
#5 [13]	23	41 M	ND	ND	ND	Left/TC	Sig	LHC	ND	Scrotal swelling	Epididymis, Spermatic cord	Orchiectomy	Survived 9 months recurrence free after orchiectomy
#6 [14]	74	30 M	ND	ND	ND	Left/DC	ND	LHC	ND	Inguinal and testicular pain as well as a hydrocele testis	Epididymis, Spermatic cord	Orchiectomy (for pain relief and diagnosis)	ND
#7 [15]	71	60 M	3	1	III	Left/Rec	Tub2	LAR	+	Scrotal swelling	ND	Orchiectomy	Recurrence in lungs and liver 6 months after orchiectomy. Later died
#8 [16]	65	74 M	2	0	I	Left/Rec	Tub2	LAR	−	Testicular enlargement and pain during chemotherapy for recurrence (74 months after first surgery)	ND	Orchiectomy (for pain relief and diagnosis)	ND
#9 [17]	40	5 M	4a	2	III	Left/SC	Por	LHC	+	Pain in inguinal region, scrotal swelling	Spermatic cord	Chemotherapy and homeopathic treatment after orchiectomy	Died 6 months after orchiectomy
#10 [18]	70	24 M	3	1	III	Right/Appe	Por	RHC after Appendicectomy	+	Scrotal swelling	Spermatic cord	Started chemotherapy after orchiectomy	ND
Our case	59	108 M	3	1a	IVA^#	Left/DC	Tub2 > Tub1	LHC	+	Discomfort in scrotum	Epididymis, Spermatic cord	Chemotherapy after orchiectomy	Survived 11 months recurrence free after orchiectomy

ND: Not Described
*AC: Ascending Colon, Appe: Appendix, DC: Descending Colon, Rec: Rectum, SC: Sigmoid Colon, TC: Transverse Colon
^†tub2: Moderately differentiated adenocarcinoma, muc: Mucinous adenocarcinoma, por: Poorly differentiated adenocarcinoma, sig: Signet-ring cell carcinoma, tub1: well-differentiated adenocarcinoma
^‡AR: Anterior Resection, LAR: Low Anterior Resection, LHC: Left Hemi Colectomy, OR: Omentum Resection, SBR: Small Bowel Resection, RHC: Left Hemi Colectomy
^#Our case was classified by the 8th version of the Union for international cancer control (UICC) TNM classification of colorectal carcinoma. For other cases, no clear classification criteria were specified in the paper

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