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Fig. 4 | Surgical Case Reports

Fig. 4

From: Acute hemorrhagic cholecystitis related to diffuse neurofibroma of gallbladder in a patient with neurofibromatosis type 1

Fig. 4

Top left panel: Low magnification image of an H&E-stained tissue sample. Diffusely proliferating bland spindle or stellate cells with abundant loose myxoid stroma can be seen occupying most of the gallbladder wall, suggesting diffuse neurofibroma. Top right panel: S-100 protein immunostaining reveals S-100 protein-positive Schwann cells and negative fibroblasts in the tumor, consistent with neurofibroma. Bottom left panel: Plexiform neurofibroma surrounded by diffuse neurofibroma within the gallbladder wall. Bottom right panel: Ulcers, erosions, hemorrhage, fibrin deposits, neutrophils, and tissue lysis, all indicative of acute cholecystitis. H&E, hematoxylin and eosin

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