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Fig. 5 | Surgical Case Reports

Fig. 5

From: Epstein–Barr virus-associated inflammatory pseudotumor variant of follicular dendritic cell sarcoma of the liver: a case report and review of the literature

Fig. 5

Oncogenesis of EBV-associated FDCS. Type 1 EBV initially infects human B lymphocytes and converts into the latency type. Then, it moves and infects the FDCs. EBER or LMP-1 protein released from the EBV to FDCs causes inhibition of cell apoptosis and proliferation of FDCs by amplification of the CD40 signaling pathways. IPT: inflammatory pseudotumor; FDCS: follicular dendritic cell sarcoma; EBV: Epstein–Barr virus; LMP-1: latent membrane protein-1; EBER: Epstein–Barr virus enucleated RNA

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