From: Liver metastasis from rectal neuroendocrine neoplasm detected 15 years after primary resection
Recurrence-free period (years) | Surgical margin | Rectal tumor size (mm) | Ki-67 (%) | Tumor depth | Treatment for rectal NEN | Lymphovascular invasion | Number of liver metastasis | Maximum size of liver metastasis (mm) | Treatment for liver metastasis | Outcome after treatment of liver metastasis | |
---|---|---|---|---|---|---|---|---|---|---|---|
Shigematsu et al. [6] | 30 | Negative | 10 | 5.0 | SM | Transanal posterior proctotomy | Absent | Multiple | 50 | Hepatectomy | Recurrence at the 1-year follow-up |
Kwaan et al. [7] | 13 | Negative | 6 | N/A | SM | Transanal resection | N/A | Multiple | N/A | N/A | N/A |
Hane et al. [5] | 13 | Negative | 12 | 1.7 | SM | Endoscopic resection | Present | Multiple | 47 | Everolimus | Stable disease at the 39-month follow-up |
Hane et al. [5] | 10 | Negative | 13 | < 1.0 | SM | Endoscopic resection | Absent | Multiple | N/A | Octreotide/everolimus/streptozocin | Died of liver metastasis at the 1-year follow-up |
Hane et al. [5] | 9 | Negative | 10 | 5 | SM | Endoscopic resection | Absent | Multiple | 15 | Radiofrequency ablation + octreotide | Recurrence at the 1-year follow-up |
Kwaan et al. [7] | 5 | Positive | 7 | N/A | SM | Endoscopic resection | N/A | Multiple | N/A | N/A | N/A |
Our case | 15 | Negative | 10 | < 2.0 | SM | Low anterior resection + lymphadenectomy | Present | Single | 7 | Hepatectomy | Recurrence-free at the 6-month follow-up |