Fig. 3

Therapy algorithm—appendectomy is the treatment of choice for acute appendicitis in immunocompetent patients. A conservative therapy with intravenous antibiotic therapy alone can be discussed in selected patients. Immunosuppressed patients divided in uncomplicated or complicated appendicitis. Septic patients with/without complicated appendicitis should always be evaluated for immediate surgical or interventional therapy, accompanied by antibiotic therapy and other supportive therapies. For a clinically stable patient presenting with an uncomplicated appendicitis, we recommend initially antibiotic and G-CSF therapy. At the onset of granulocyte regeneration, shown in the evidence of monocyte increase, the delayed appendectomy should be performed, for an adequate wound healing