Microcystic serous cystadenoma mimicking pancreatic neuroendocrine neoplasm: report of a resected case with preoperative diagnostic difficulty and review of the literature

Surgical Case Reports

Table 2 Clinical series in which surgical resection was performed with preoperative diagnosis of pNEN and postoperative pathological diagnosis of SCA was obtained

Case no.	Author	Year	Age/sex	Location	Enhanced CT findings	EUS findings	EUS-FNA	Surgical procedure	Postoperative diagnosis
1	Yamamoto et al. [21]	2004	60/M	UP	Hypervascular, uniformly	N/A	N/A	Enucleation	SCA solid variant
2	Yamaguchi et al. [22]	2006	58/F	Pb	Enhanced in arterial phase	N/A	N/A	DP	Solid serous adenoma
3	Reese et al. [23]	2006	66/M	Ph	Hypervascular	N/A	N/A	PD	Solid serous adenoma
4	Sanaka et al. [24]	2007	74/M	Pb	Hypervascular	Hypoechoic	Inconclusive	Enucleation	Solid serous adenoma
5	Yasuda et al. [25]	2011	72/F	Ph	Hypervascular	No cyst	N/A	PD	SCA solid variant
6	Kishida et al. [26]	2014	58/M	Pb	Hypervascular	N/A	N/A	DP	SCA solid variant
7	Sagami et al. [27]	2015	67/M	Ph	Unilocular tumor with wall thickening	Hypoechoic	N/A	PD	Macrocystic type SCN
8	Wu et al. [28]	2015	48/M	Ph	Enhanced in arterial phase	N/A	N/A	PD	SCA solid variant
9	Wu et al. [28]	2015	65/F	Pb	Enhanced in arterial phase	N/A	N/A	DP	SCA solid variant
10	Katsourakis et al. [29]	2016	72/F	Pt	N/A	N/A	Inconclusive	DP	Solid serous adenoma
11	Hamid et al. [30]	2017	53/F	Pb	Solid	N/A	N/A	DP	SCA solid variant
12	Yamashita et al. [31]	2018	32/F	Ph	Hypervascular	Hypoechoic	NET	PD	VHL-associated MSNNs
13	Demesmaker et al. [32]	2019	63/M	Ph	Hypervascular	Hypoechoic	Negative	PD	SCA solid variant
14	Nappo et al. [3]	2020	63/M	Pb, Pt	N/A	Hypoechoic	Inconclusive	DP	Microcystic SCA
15	The present case	2021	27/M	Pt	Hypervascular, uniformly	Hyperechoic	Inconclusive	DP	Microcystic SCA

EUS-FNA: endoscopic ultrasound-fine needle aspiration; UP: uncinate process of the pancreas; Ph: pancreatic head; Pb: pancreatic body; Pt: pancreatic tail; DP: distal pancreatectomy; PD: pancreaticoduodenectomy; SCA: serous cystadenoma; SCN: serous cyst neoplasm; VHL-associated MSNNs: Von Hippel–Lindau-associated mixed serous neuroendocrine neoplasms; N/A: not applicable