Long-term survival of an adult patient with undifferentiated embryonal sarcoma of the liver with multidisciplinary treatment: a case report and literature review

Endo, Yukiko Kumata; Fujio, Atsushi; Murakami, Keigo; Sasaki, Kengo; Miyazawa, Koji; Kashiwadate, Toshiaki; Tokodai, Kazuaki; Miyagi, Shigehito; Fujishima, Fumiyoshi; Unno, Michiaki; Kamei, Takashi

doi:10.1186/s40792-022-01436-3

Surgical Case Reports

Table 1 Previous studies’ clinical parameters of adult patients with UES who survived over 48 months

From: Long-term survival of an adult patient with undifferentiated embryonal sarcoma of the liver with multidisciplinary treatment: a case report and literature review

References	Author	Year	Age/sex		Localization	Maximum diameter (cm)	Initial treatment	Resection margin	Adjuvant chemotherapy	Recurrence	Location of recurrence		Outcome
[8]	Grazi	1996	25/M	67.6	Right lobe	15	Surgery	Inrtaoperative tumor rupture	None	Yes	Liver	Operation	DOD
[9]	Almogy	2004	25/F	60	Right lobe	14	Surgery	Negative	Ifosfamide, doxorubicin, mesna	Yes	Liver, bone	VAC	RBS
[10]	Almogy	2005	21/F	75	Right lobe	15	Surgery	Intraoperatively, another lesion was pointed out	N.A	N.A	Intrahepatic region noted in the first surgery	Operation, ifosfamide, doxorubicin, mesna	NED
[11]	Sebastien	2005	18/F	48	Right lobe	26	Surgery	N.D	VAC	Yes	Intra-abdominal	Operation, chemotherapy	DOD
[12]	Lentz	2008	34/F	72	Right lobe	20	Surgery	Free	None	Yes	Liver, intra-abdominal	Carboplatin, etoposide, doxorubicin, ifosfamide	NED
[13]	Tsukada	2010	21/F	60	Right lobe	12	Surgery	N.D	None	No	–		NED
[14]	Kim	2011	47/F	48	Left lobe	13	Surgery	N.D	MAID	Yes	Bone	RT	NED
[15]	Dhanasekaran	2012	53/M	126	Left lobe	30	Chemotherapy → Tx	N.A	None	No	–		NED
[16]	Noguchi	2012	27/F	60	Right lobe	21	Surgery	Negative	VADRCA + CDDP + RT, Peripheral stem cell extraction	No			NED
[17]	Masuda	2015	52/F	62	Right lobe	23	Surgery	N.D	None	Yes	Liver	Operation, TACE(CDDP 50 mg + lipiodol 2.5 ml, epirubicin)	DOD
[17]	Masuda	2015	53/F	65	Left lobe	22	Surgery	N.D	None	Yes	Liver	Operation, TACE(CDDP 80 mg + lipiodol 4 ml, 5-FU 1000 mg)	RBS
[4]	Esteban	2018	41/F	60	Right lobe	26	Surgery	Negative	None	Yes	Liver	GEM + DOC	RBS
[18]	Beksac	2018	26/F	72	Left lobe	25	Surgery	N.D	Taxol, Cisplatin, ifosfamide	No			NED
[19]	Capozza	2019	20/F	168	Right lobe	15	Surgery	Negative	VAIA	No			NED
[3]	Babu	2021	31/F	120	Left lobe	10.3	Surgery	N.D	Cyclophosphamide, vincristine	Yes	Liver	Chemotherapy (cyclophosphamide, vincristine) → Tx	NED
	Our case	2021	33/F	49	Right lobe	17	Surgery	Negative	None	Yes	Liver	Fig. 5	DOD

UES undifferentiated embryonal sarcoma of the liver, Tx transplantation, VAC vincristine, actinomycin-D and cyclophosphamide, MAID mesna, doxorubicin, ifosfamide and dacarbazine, VAIA vincristine, actinomycin-D, ifosfamide and doxorubicin, VADRCA vincristine, doxorubicin, actinomycin-D and cyclophosphamide, CDDP cisplatin, RT radiation therapy, TACE transcatheter arterial chemoembolization, 5-FU 5-fluorouracil, GEM gemcitabine, DOC docetaxel, ND not documented, NA not applicable, NED no evidence of disease, DOD died of disease, RBS recurrence but survived

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