Pathological complete response achieved by gemcitabine plus cisplatin therapy for initially unresectable advanced gallbladder cancer: a case report

Miura, Yuya; Ashida, Ryo; Sugiura, Teiichi; Ohgi, Katsuhisa; Yamada, Mihoko; Otsuka, Shimpei; Todaka, Akiko; Uesaka, Katsuhiko

doi:10.1186/s40792-022-01375-z

Surgical Case Reports

Table 1 The cases diagnosed initially with an unresectable gallbladder cancer and could be performed radical resection

From: Pathological complete response achieved by gemcitabine plus cisplatin therapy for initially unresectable advanced gallbladder cancer: a case report

No	Author reference (year)	Age (yeaears)	Reasons for unresectability	Chemotherapy	*Interval (months)	Surgery	Residual tumor status	Histological evaluation	Postoperative survival (months)	Status
1	Morimoto et al. [9] (2008)	69	Liver metastasis	GEM	12	GBR, partial resection of the duodenum and the colon, partial liver resection of segment 8, lymphadenectomy	R0	PR	20	Alive
2	Sharma et al. [5] (2010)	N/A	N/A	GEM + oxaliplatin	N/A	N/A	N/A	N/A	N/A	N/A
3	Takita et. al [10] (2011)	57	Metastasis of para-aortic lymph node	GEM + S-1	9	GBR, lymphadenectomy	R0	PR	12	Alive
4	Kato et al. [11] (2013)	57	Arterial infiltration portal vein infiltration	GEM	N/A	Right hemi-hepatectomy with caudal lobectomy, EBDR, lymphadenectomy	R0	N/A	42	Alive
5	Kato et al. [11] (2013)	57	Arterial infiltration	GEM	N/A	Right hemi-hepatectomy with caudal lobectomy, EBDR, lymphadenectomy	R1	N/A	18	Dead
6	Kato et al. [11] (2013)	57	Arterial infiltration	GEM	N/A	Hepatectomy of segment 4a and 5, EBDR, lymphadenectomy	R1	N/A	19	Dead
7	Kato et al. [11] (2013)	61	Arterial infiltration, duodenal infiltration	GEM	N/A	Hepatectomy of segment 4a and 5, EBDR, lymphadenectomy	R1	N/A	8	Dead
8	Einama et al. [12] (2014)	60	Arterial infiltration	S-1	36	Right hemi-hepatectomy, EBDR, lymphadenectomy	R0	PR	30	Alive
9	Rama et al. [13] (2014)	64	Metastasis of para-aortic lymph node	GEM + CDDP	6	GBR, EBDR, lymphadenectomy	R0	PR	6	Alive
10	Kato et al. [14] (2015)	62	Arterial infiltration	GEM + CDDP	9	Right hepatic trisegmentectomy, with caudal lobectomy, EBDR, Lymphadenectomy	R0	PR	N/A	Dead
11	Tsuyuki et al. [15] (2018)	76	Metastasis of para-aortic lymph node	GEM + CDDP	6	GBR, lymphadenectomy	R0	PR	7	Alive
12	Hashimoto et al. [7] (2019)	47	Local advanced	GEM + CDDP	6	GBR, lymphadenectomy	R0	CR	14	Alive
13	Kato et al. [8] (2020)	59	Metastasis of para-aortic lymph node	GEM + CDDP	6	GBR, EBDR, lymphadenectomy	R0	CR	11	Alive
14	Present case	71	Metastasis of para-aortic lymph node	GEM + CDDP	49	GBR, lymphadenectomy	R0	CR	18	Alive

N/A not available, GEM gemcitabine, PR partial response, S − 1, tegafur/gimeracil/oteracil, GBR gallbladder bed resection, EBDR extrahepatic bile duct resection, SD stable disease, CDDP cisplatin, CR complete response
*Interval to surgery from the first chemotherapy

Back to article page