Fig. 1

A series of measurable tumor sizes and lenvatinib doses over time. Lenvatinib dose and duration of treatment are shown in the upper part of the graph (black boxes). The size of the three measurable sites (neck: pre-laryngeal lymph node, lung: largest mass in the right lobe, adrenal: left) are represented by dashed or solid lines with open circles, boxes, and triangles, respectively. Four arrows indicate the dates of computed tomography (CT) scans shown in Fig. 2