Table 1 Summary of previous similar case reports
From: Squamous cell carcinoma of the uterine cervix metastasising to the thyroid gland: a case report
Author (year) | Clinical presentation | Biochemistry | Imaging | Histology | Treatment | Outcome |
|---|---|---|---|---|---|---|
Martino (1977) | A 39-year-old female with thyroid enlargement for 2 months. Radical hysterectomy and lymphadenectomy for a stage I cervical SCC 2 years ago | Basic biochemistry: normal. Thyroid profile and uptake scan: normal Anti-Tg Ab: undetectable | CXR: sharply outlined nodule in right lung hilum | The thyroid biopsy specimen showed a poorly differentiated SCC | Thyroidectomy was abandoned due to a large mass with gross infiltration of the trachea and the left neurovascular structures. A biopsy specimen was obtained | Died in 4 months due to rapid enlargement of the tumour and metastases. Post-mortem examination showed wide-spread metastasis |
Singh (2002) | A 38-year-old female with a rapidly growing neck mass. Radical hysterectomy and adjuvant chemoradiation for a stage IB neuroendocrine cervical carcinoma 1 year ago | Blood counts, basic biochemistry and thyroid profile were normal | MRI: large mass in the right side of the neck, which replaced the right thyroid lobe, and bilateral apical lung masses. CT: Multiple lesions in the liver | Biopsy of the thyroid and liver lesions revealed a poorly differentiated carcinoma. IHC panel was compatible with a neuroendocrine cervical carcinoma | Chemotherapy was initiated but developed significant adverse effects with the fourth cycle | Died 6 months after the diagnosis |
Karapanagiotou (2006) | A 68-year-old female with cough, haemoptysis painless palpable thyroid swelling. History of Stage IIIB cervical SCC 4 years ago | Blood count and basic biochemistry: Normal ESR: 65 | CT: large irregular mass (9 cm in diameter) in the neck, thyroid enlargement, enlarged mediastinal and para-aortic nodes, and multiple patchy lung infiltrates, no local recurrence Bone scan: negative | Bronchoscopy washing and brushing was positive for undifferentiated carcinoma Biopsy of the thyroid gland was performed, which showed non-keratinising SCC | 6 cycles of systemic chemotherapy and local radiotherapy | Died 16 months after the diagnosis |
Fuentes-Martinez (2015) | A 36 year-old woman with a thyroid nodule for one month. Radical chemotherapy for a hardly differentiated stage IA cervical carcinoma 1 year ago | NA | CT: an irregular nodule measuring 5 cm that occupied a large part of the right thyroid lobe | Fine needle aspiration showed hardly differentiated malignant cells | The patient received palliative treatment with radiotherapy and chemotherapy | Died 6 months after diagnosis |
Celik (2016) | A 56-year-old female with thyroid lumps and dysphagia. Radical hysterectomy and adjuvant chemoradiation for a cervical SCC 6 months ago | Basic biochemistry, thyroid profile, Tg, anti-Tg Ab: normal | USS: multiple thyroid nodules with micro- and macro-calcifications PET/CT: multiple lung, spine, lymph node metastasis | Multiple islands of atypical mitotically active squamous cells in the thyroid | Palliative total thyroidectomy and central lymph node dissection | Died in 5 months due to rapid progressions of the disease |
Varli (2018) | A 55-year-old female with a painless enlargement in the thyroid gland causing dyspnoea. She underwent radical surgery and chemoradiation for a stage IIA poorly differentiated cervical SCC | Basic biochemistry: normal. TSH was 0.02 IU/ml. Her fT3, fT4 and thyroid autoantibodies were normal | Ultrasonography: multinodular goitre. Pre-treatment PET/CT showed thyroid gland abnormalities with retrosternal elongation and metabolically inactive nodules, largest: 3 cm | Total thyroidectomy showed metastasis with squamous differentiation which was also identical to her treated cervical tumour | Total thyroidectomy | NA |