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Fig. 4 | Surgical Case Reports

Fig. 4

From: INI1-negative colorectal undifferentiated carcinoma with rhabdoid features and postoperative rapidly growing liver metastases: a case report and review of the literature

Fig. 4

Sigmoid colon tumor cells had polymorphic nuclei and eosinophilic cytoplasm. These cells had poor connectivity with each other. These characteristics are called rhabdoid features, because the morphology of these cells is similar to that of rhabdomyosarcoma tumor cells (HE × 200) (a). Immunohistochemical examination showed that the tumor cells were positive for both epithelial (cytokeratin AE1/AE3) (× 200) (b) and mesenchymal cell markers (vimentin) (× 200) (c). These tumor cells were negative for INI1 (arrow), on the other hand, the surrounding non-neoplastic cells were positive for INI1 (arrowhead) (× 400) (d). Contrast to the tumor cells, non-tumor crypt epithelium cells were INI1 positive (× 100) (e). The tumor cells were negative for CDX2, which is a marker of colonocytes differentiation (× 200) (f)

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