Fig. 4

Histopathological examination of the multiple tumors. a All tumors except for two tumors in segments 4 and 6 were composed of well to moderately differentiated adenocarcinoma cells, growing in tubular or in a cribriform pattern. b The tumor in segment 6 showed a proliferation of atypical cells with rounded nuclei and eosinophilic cytoplasm that were arranged in a small nested pattern, accompanied by fibro-collagenous stroma. c Immunohistochemical examination of the tumor cells in segments 4 and 6 revealed that they were differentiation (CD) 56-positive. d Immunohistochemical examination of the tumor cells in segments 4 and 6 revealed that they were chromogranin-A-positive. e Immunohistochemical examination of the tumor cells in segments 4 and 6 revealed that they were synaptophysin-positive. f Immunohistochemical examination of the tumor cells in segments 4 and 6 revealed that the MIB-1 labeling index was less than 1%