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Surgical Case Reports
Fig. 3 | Surgical Case Reports

Fig. 3

From: Mixed adenoneuroendocrine carcinoma with loss of HER2 positivity after trastuzumab-based chemotherapy for HER2-positive gastric cancer: a case report

Fig. 3

Microscopic examination of the stomach and liver of the resected specimen. Histopathological examination of the primary gastric cancer revealed that it was composed of enriched solid and small nested growths of high nuclear cytoplastic ratio tumor cells with necrosis and fibrosis, which had atypical enlarged hyperchromatic nuclei (a). Histopathological examination of the liver showed that the tumors were pathologically compatible with metastases from the gastric cancer (b). The immunohistochemical HER2 scores were 1 for the primary gastric cancer and 0 for the liver metastases (primary gastric cancer (c), liver metastasis (d))

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