Table 1 Reported cases of spontaneous regression of breast cancer
From: Temporary spontaneous regression of male breast cancer: a case report
References | Year | Age/sex | Suggested mechanism | Possible trigger | Regression | Pathologically verified SR |
|---|---|---|---|---|---|---|
[7] | 1994 | 46 F | Immunological response mediated by activated CD8 + T cells and NK cells | Treatment with dexamethasone | Regression of primary tumor and metastatic lesion | − |
[8] | 2008 | 68 F | Immunological and local inflammatory response | Arm injury Needle biopsy | Complete regression of primary tumor | + |
[4] | 2014 | 52 F | Immunological response | Unclear | Nearly complete regression of primary tumor and complete regression of metastatic lymph nodes | + |
[9] | 2016 | 44 F | Immunological response | Needle biopsy | Complete regression of primary tumor | + |
[6] | 2019 | 67 F | Immunological response | Unclear | Nearly complete regression of primary tumor and complete regression of metastatic lymph nodes | + |
[10] | 2019 | 72 F | Immunological response mediated by activated CD8 + T cells | Unclear | Complete regression of primary tumor and metastatic lymph nodes | + |
[11] | 2020 | 86 F | Immunological response mediated by activated CD8 + T cells | Unclear | Regression of metastatic skin lesions | − |
Our case | 2020 | 70 M | Ischemia/infarction | Unclear | Regression of primary tumor followed by reappearance | − |