Fig. 4

Histopathological examinations of biopsy before chemotherapy. a Atypical cells with enlarged chromatin nuclei and eosinophilic endoplasmic reticulum form vesicular nests on hematoxylin–eosin stain. b D2-40 staining is positive, indicating that the tumor cells have infiltrated the lymphatic vessels. c Atypical cells with enlarged nuclei and eosinophilic sporangium form a vesicular structure and proliferate. It is a highly atypical invasive ductal carcinoma of the breast