Fig. 6

Microscopic and immunohistochemical findings of the choriocarcinoma. High magnification photomicrograph enclosed in a black square in a is presented in b–n. The medullary portion contained small carcinoma cells with a tendency to differentiate into layers (a, b). These poorly differentiated squamous cell carcinoma-like cell clusters were negative for hCG, p40, αSMA, glypican-3, AFP, Oct3/4, CD146, S100 and CEA (c, f, i–m, o, p) and focally positive for p53, CK5/6, SALL4, PLAP and EMA (d, e, g, h, n) using immunohistochemical staining