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Table 1 25 reported cases of primary extrahepatic bile duct neuroendocrine carcinoma

From: Rapidly progressed neuroendocrine carcinoma in the extrahepatic bile duct: a case report and review of the literature

Year Author Age/Sex Location Symptom Preoperative diagnosis Operation Histology Size
(mm)
Ki 67 Index
(%)
LN metastasis Adjuvant therapy Recurrence RFS
(months)
Recurrent organ Outcome
2003 Kuraoka 75M Bd jaundice BDC PD SCNEC 45 90 + ND + 5 LN ND
2003 Hazama 60M Bd jaundice SCC PD SCNEC 3 ND + - + 11 brain, LN 12M dead
2005 Kaiho 66F Bd pain BDC PD SCNEC + a 35 ND ND +, ND + ND liver 8M dead
2006 Sato 68M Bd jaundice BDC PD LCNEC + a 20 71.4 - ND + 2 liver 3M dead
2009 Kohashi 77M Bd jaundice BDC PD LCNEC 18 67 - - + 3 liver, lung, local 3M dead
2009 Okamura 62M Bd abdominal pain, fever SCC PD SCC 30 ND ND +, IP + 8 bone 20M dead
2011 Masui 82M Bd jaundice, anorexia BDC EHBDR AECC 25 35 - - + 3 liver 6M dead
2012 Takahashi 28F Bd pruritus BDC PD NEC 30 89.8 - - - 36 none 36M alive
2013 Sasatomi 76M Bp jaundice BDC H + EHBDR LCNEC 50 75 + - + 0 LN 21days dead
2013 Linder 82M Bd jaundice, abdominal pain, weight loss BDC PD MANEC 19 ND + - - 6 none 6M alive
2014 Lee 75M Bd jaundice BDC EHBDR MANEC 20 ND - - - 11 none 11M alive
2014 Wysocki 65M Bp jaundice, vomit, weight loss ND EHBDR LCNEC + a 36 80 ND - ND ND ND 5M dead
2014 Park SB 75F Bd nausea, jaundice BDC EHBDR LCNEC 27 ND + +, 5-FU+CDDP + 7 liver, local 12M dead
2015 Aigner 61M Bd abdominal pain, icterus, nausea, pruritus SCNEC EHBDR SCNEC 27 90 ND ND + 3 liver, LN, bone ND
2015 Kihara 70F Bp jaundice BDC H + EHBDR SCNEC 30 70 + +, CPT-11+CBDCA - 10 none 10M alive
2016 Priyanka 76M Bp jaundice, weight loss BDC EHBDR MANEC 14 90 - - ND ND ND ND
2016 Murakami 80M Bp jaundice BDC EHBDR LCNEC + a 24 72 + - + 2.5 Liver, lung, P 3M dead
2016 Oshiro 72M Bp jaundice BDC H + EHBDR LCNEC 30 56.2 + - + 3 Liver 7M alive
2017 Izumo 66M Bd jaundice, anorexia, fatigue BDC PD MANEC 10 30 + - - 30 none 30M alive
2017 Komo 82M Bd Liver dysfunction BDC PD MANEC 18 37 - - - 7 none 7M alive
2018 Zhang L 62M Bp jaundice BDC H + EHBDR NEC 20 80 + - + 2 liver 6M dead
2018 Park JY 59M Bp jaundice BDC EHBDR LCNEC 62 20 - +, RT+VP-16+CDDP - 10 none 10M alive
2019 Zhang HW 60M Bp abdominal pain ND EHBDR MANEC 17 70 + ND ND ND ND ND
2019 Zhang L 64F Bd jaundice, abdominal pain BDC PD MANEC 45 50 ND - + 5 liver, lung 12M dead
2020 our case 84M Bd jaundice BDC PD SCNEC + a 25 80 + - + 1 liver 3M dead
  1. LN lymph node, RFS recurrence-free survival, Bd distal bile duct, Bp perihilar bile duct, BDC bile duct cancer, SCC small-cell carcinoma, ND no data, SCNEC small-cell neuroendocrine carcinoma, PD pancreatoduodenectomy, EHBDR extrahepatic bile duct resection, H+ hemihepatectomy+, +a +adenocarcinoma, LCNEC large-cell neuroendocrine carcinoma, AECC adenoendocrine carcinoma, MANEC mixed adenoneuroendocrine carcinoma, IP irinotecan+cisplatin, 5-FU 5-fluorouracil, CDDP cisplatin, CPT-11 irinotecan, CBDCA carboplatin, RT radiotherapy, VP-16 etoposide, P peritoneal metastasis