Rapidly progressed neuroendocrine carcinoma in the extrahepatic bile duct: a case report and review of the literature

Kamiya, Mariko; Yamamoto, Naoto; Kamioka, Yuto; Inoue, Hirohide; Yotsumoto, Hirokazu; Murakawa, Masaaki; Aoyama, Toru; Washimi, Kota; Kawachi, Kae; Oshima, Takashi; Ueno, Makoto; Yukawa, Norio; Rino, Yasushi; Masuda, Munetaka; Morinaga, Soichiro

doi:10.1186/s40792-020-00945-3

Surgical Case Reports

Table 1 25 reported cases of primary extrahepatic bile duct neuroendocrine carcinoma

From: Rapidly progressed neuroendocrine carcinoma in the extrahepatic bile duct: a case report and review of the literature

Year	Author	Age/Sex	Location	Symptom	Preoperative diagnosis	Operation	Histology	Size (mm)	Ki 67 Index (%)	LN metastasis	Adjuvant therapy	Recurrence	RFS (months)	Recurrent organ	Outcome
2003	Kuraoka	75M	Bd	jaundice	BDC	PD	SCNEC	45	90	+	ND	+	5	LN	ND
2003	Hazama	60M	Bd	jaundice	SCC	PD	SCNEC	3	ND	+	-	+	11	brain, LN	12M dead
2005	Kaiho	66F	Bd	pain	BDC	PD	SCNEC + a	35	ND	ND	+, ND	+	ND	liver	8M dead
2006	Sato	68M	Bd	jaundice	BDC	PD	LCNEC + a	20	71.4	-	ND	+	2	liver	3M dead
2009	Kohashi	77M	Bd	jaundice	BDC	PD	LCNEC	18	67	-	-	+	3	liver, lung, local	3M dead
2009	Okamura	62M	Bd	abdominal pain, fever	SCC	PD	SCC	30	ND	ND	+, IP	+	8	bone	20M dead
2011	Masui	82M	Bd	jaundice, anorexia	BDC	EHBDR	AECC	25	35	-	-	+	3	liver	6M dead
2012	Takahashi	28F	Bd	pruritus	BDC	PD	NEC	30	89.8	-	-	-	36	none	36M alive
2013	Sasatomi	76M	Bp	jaundice	BDC	H + EHBDR	LCNEC	50	75	+	-	+	0	LN	21days dead
2013	Linder	82M	Bd	jaundice, abdominal pain, weight loss	BDC	PD	MANEC	19	ND	+	-	-	6	none	6M alive
2014	Lee	75M	Bd	jaundice	BDC	EHBDR	MANEC	20	ND	-	-	-	11	none	11M alive
2014	Wysocki	65M	Bp	jaundice, vomit, weight loss	ND	EHBDR	LCNEC + a	36	80	ND	-	ND	ND	ND	5M dead
2014	Park SB	75F	Bd	nausea, jaundice	BDC	EHBDR	LCNEC	27	ND	+	+, 5-FU+CDDP	+	7	liver, local	12M dead
2015	Aigner	61M	Bd	abdominal pain, icterus, nausea, pruritus	SCNEC	EHBDR	SCNEC	27	90	ND	ND	+	3	liver, LN, bone	ND
2015	Kihara	70F	Bp	jaundice	BDC	H + EHBDR	SCNEC	30	70	+	+, CPT-11+CBDCA	-	10	none	10M alive
2016	Priyanka	76M	Bp	jaundice, weight loss	BDC	EHBDR	MANEC	14	90	-	-	ND	ND	ND	ND
2016	Murakami	80M	Bp	jaundice	BDC	EHBDR	LCNEC + a	24	72	+	-	+	2.5	Liver, lung, P	3M dead
2016	Oshiro	72M	Bp	jaundice	BDC	H + EHBDR	LCNEC	30	56.2	+	-	+	3	Liver	7M alive
2017	Izumo	66M	Bd	jaundice, anorexia, fatigue	BDC	PD	MANEC	10	30	+	-	-	30	none	30M alive
2017	Komo	82M	Bd	Liver dysfunction	BDC	PD	MANEC	18	37	-	-	-	7	none	7M alive
2018	Zhang L	62M	Bp	jaundice	BDC	H + EHBDR	NEC	20	80	+	-	+	2	liver	6M dead
2018	Park JY	59M	Bp	jaundice	BDC	EHBDR	LCNEC	62	20	-	+, RT+VP-16+CDDP	-	10	none	10M alive
2019	Zhang HW	60M	Bp	abdominal pain	ND	EHBDR	MANEC	17	70	+	ND	ND	ND	ND	ND
2019	Zhang L	64F	Bd	jaundice, abdominal pain	BDC	PD	MANEC	45	50	ND	-	+	5	liver, lung	12M dead
2020	our case	84M	Bd	jaundice	BDC	PD	SCNEC + a	25	80	+	-	+	1	liver	3M dead

LN lymph node, RFS recurrence-free survival, Bd distal bile duct, Bp perihilar bile duct, BDC bile duct cancer, SCC small-cell carcinoma, ND no data, SCNEC small-cell neuroendocrine carcinoma, PD pancreatoduodenectomy, EHBDR extrahepatic bile duct resection, H+ hemihepatectomy+, +a +adenocarcinoma, LCNEC large-cell neuroendocrine carcinoma, AECC adenoendocrine carcinoma, MANEC mixed adenoneuroendocrine carcinoma, IP irinotecan+cisplatin, 5-FU 5-fluorouracil, CDDP cisplatin, CPT-11 irinotecan, CBDCA carboplatin, RT radiotherapy, VP-16 etoposide, P peritoneal metastasis

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