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Table 1 Clinical literature review of parathyroid carcinoma in children under 16

From: Parathyroid carcinoma in a 13-year-old girl with a long-term survival

YearSexAgeCa, mg/dLi-PTH, pg/mLSymptomsFamily historyPalpable neck massOperationOutcome
1973 [2]13
1984 [3]M15112.6PancreatitisNoPTx
1984 [1]
This case
F1315.9Bone painNoPTxLung meta at 9, 20 yrs
Local rec at 42 yrs
1993 [4]M1413.2353Bone painYesYesEn bloc resectionNo rec after 2 yrs
1999 [5]M1520.7154Fatigue, nausea, weight lossYesEn bloc resectionNo rec after 1 yr
2002 [6]F814.382Renal stoneYesYesPTxNo rec after 16 ms
2009 [7]M1015.5Anorexia, fatigue, knee painYesNoMediastinal PTx, thymectomyNo rec after 18 ms
2011 [8]F1414.32792ArthralgiaNoHTxNo rec after 18 ms
2012 [9]F1312.08363NoneNoYesEn bloc resectionLung meta after 6 ms
2012 [10]M111630Bowing legs with painPTx→HTx
2015 [11]F1012.22217Abdominal pain, joint deformity
2016 [12]F812.5453NoPTxLocal rec at 5 yrs
Lung meta at 5 yrs
2016 [13]M1417.11164Hip painNoYesEn bloc resectionNo rec after 1 yr
2016 [14]F1413.41013Leg painNoYesEn bloc resectionNo rec after 6 ms
2019 [15]F1515.81170Fever, fatigueNoYesEn bloc resectionNo rec after 2 yrs
2020 [16]M1315.4980Polyuria, polydipsia, leg painNoEn bloc resectionNo rec after 1.5 yrs
2020 [17]M1014.31075Back painPTx
  1. Ca calcium, i-PTH intact parathyroid hormone, BMD bone mineral density, HPT hyperparathyroidism, yr year, m month, PTx parathyroidectomy, HTx hemithyroidectomy, meta metastasis, rec recurrence