Fig. 3

Time series of the esophageal findings on upper endoscopy and CT. a After 6 months of the PBT, mucosal inflammation is noted in the lower esophagus. After 7 months of the PBT, b there is worsening of the esophageal ulcer into full-thickness necrosis, and c CT reveals a wall defect on the right side of the lower esophagus (white arrowheads). CT, computed tomography; PBT, proton beam therapy