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Fig. 5 | Surgical Case Reports

Fig. 5

From: Dyspnea due to an uncommon vascular tumor: leiomyosarcoma of the infrahepatic vena cava inferior

Fig. 5

Histopathological findings. All staining was carried out on formalin-fixed paraffin-embedded (FFPE) tissue. a Monoclonal antibodies to the Ki67 antigen (Anti-Ki67) were applied to flag cells in the G1, S, G2, and M phase of their cell cycle, but not in the resting phase G0. Despite the fact that intraobserver and interobserver reproducibility of the visual assessment of Ki67 expression in IHC are low [12], there was a consensus that the tumor showed considerable activity. b The tumor cells revealed a specific, strong, and diffuse cytoplasmatic reactivity for antibodies to smooth muscle actin (Anti-α-Actin) as seen in cases of LMS. c The cytoplasmatic reactivity of tumor cells with antibodies to desmin (Anti-Desmin) as shown here might be associated with improved survival as the expression of this antigen can help predict the outcome by segregating moderately differentiated LMS into two groups, those that behave like well-differentiated tumors by expressing desmin and those that behave like poorly differentiated tumors by not expressing it [13]. d Hematoxylin and Eosin (H&E) staining revealed tumor cells with pleomorphic nuclei and eosinophilic cytoplasmata

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