Marker | Characteristic | |
---|---|---|
Positive | Inhibin-α | Inhibin-α is present in most sex cord-stromal cells, and the sensitivity and specificity of inhibin-α for detecting sex cord-stromal tumors is 56% and 96%, respectively [5]. |
CD99 | CD99 is detected on the cell surface of Ewing’s sarcoma tumors, ependyma, and granulosa cell tumors. | |
CD56 | Neuroendocrine tumors are positive for CD56, and CD56 is a marker for granulosa cell tumors. CD56 is useful in distinguishing between granulosa cell tumors and normal ovarian follicles or endometrioid adenocarcinomas [6]. | |
Negative | SALL4 | SALL4 is a marker for germ cell tumors. |
AFP | AFP is a fetal protein and a marker for hepatocellular carcinoma, hepatoblastoma, and germ cell tumors. | |
β-HCG | Villous tumors are positive for HCG. |