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Table 1 Markers for immunostaining

From: Right trisectionectomy for liver metastasis of granulosa cell tumor: a case report and literature review

 

Marker

Characteristic

Positive

Inhibin-α

Inhibin-α is present in most sex cord-stromal cells, and the sensitivity and specificity of inhibin-α for detecting sex cord-stromal tumors is 56% and 96%, respectively [5].

CD99

CD99 is detected on the cell surface of Ewing’s sarcoma tumors, ependyma, and granulosa cell tumors.

CD56

Neuroendocrine tumors are positive for CD56, and CD56 is a marker for granulosa cell tumors. CD56 is useful in distinguishing between granulosa cell tumors and normal ovarian follicles or endometrioid adenocarcinomas [6].

Negative

SALL4

SALL4 is a marker for germ cell tumors.

AFP

AFP is a fetal protein and a marker for hepatocellular carcinoma, hepatoblastoma, and germ cell tumors.

β-HCG

Villous tumors are positive for HCG.

  1. AFP α-fetoprotein, β-HCG β-human chorionic gonadotropin, SALL4 Sal-like protein 4