Table 2 Reported cases of hepatocellular adenoma with high levels of serum PIVKA-II
No | Authors (year) | Age (years) | Sex | BMI | Tumor sites in the liver | Maximum tumor size (cm) | PIVKA-II (mAU/mL) | HCA classification | Malignant transformation | Lipofuscin deposition |
|---|---|---|---|---|---|---|---|---|---|---|
1 | Uto et al. [21] | 21 | M | 23.9 | Single, posterior segment | 10 × 8 | 2200 | No data | (−) | (−) |
2 | Ito et al. [22] | 57 | F | – | Single, lateral segment | 10 × 10 × 8 | 3502 | No data | (+) | (−) |
3 | Seyama et al. 23 | 27 | F | – | Multiple, S5, S8, S7 | 12 × 10 (S5) | 6647 | No data | (−) | (−) |
4 | Sakamoto et al. [23] | 21 | M | – | Multiple, S2, S3, S4, S5/7, S7 | 3.6 | 107 | No data | (−) | (−) |
5 | Iguchi et al. [19] | 46 | F | 19.8 | Multiple, lateral segment, S4, S1 | 10 × 8.5 (lateral) | 10,100 | β-catenin (+), but exon 3 (−) | (+) | (−) |
6 | Koya et al. [24] | 34 | M | 26.8 | Single, posterior segment | 7 × 10 | 76.0 | Concurrent Inflammatory+β-catenin activated | (−) | (+) |
7 | Koya et al. [24] | 24 | M | Normal | Single, lateral segment | 7 × 5.5 | 75.4 | Inflammatory | (−) | (−) |
8 | Our case (2019) | 44 | F | 10.9 | Single, segments S4 + S5 | 9 × 4.8 | 3327 | Unclassified | (−) | (+) |