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Table 1 Reported biliary adenofibromas of the liver (n = 22)

From: A case of biliary adenofibroma of the liver with malignant transformation: a morphomolecular case report and review of the literature

No. Reference Age/sex Tumor size (cm) p53 Ki67 (%) Evidence of malignant transformation Mutations found
1 Tsui et al. [2] 74/f 7    No  
2 Parada et al. [5] 49/f 7    No  
3 Akin and Coskun [4]      Pulmonary metastasis  
4 Garduno-Lòpez et al. [6] 68/m 6    No  
5 Varnholt et al. [7] 21/f 16    No  
6 Gurrera et al. [8] 79/m 5.5    No  
7 Kai et al. [9] 40/m 7 Negative 5–10 Atypias  
8 Nguyen et al. [10] 53/f 6.5    Yes  
9 Nakanuma et al. [11] 69/f 3.5 Focally positive 10–15 Yes  
10 Jacobs et al. [12] 57/f 10    Atypias  
11 Thai et al. [13] 77/m 4.8    Yes  
12 Godambe et al. [14] 71/f 6.3 50% 20–50 Yes  
13 Thompson et al. [15] 71/m 14.5    Yes Nonsense mutation in p16 INK4a
14 Kaminsky et al. [3] 37/f 4.5 Negative 50 Yes  
15 Arnason et al. [16] 83/m 7     
16   47/f 16   6 Atypias Large region gains in chromosome 1q; loss of 1p, 2p, 3q, 6q, 8p, 11p, 12q, 14, 16q
17   57/f 10; 2.5; 1.7 Positive < 10 Atypias gain of 1q; loss of 11q, 22q, Xq; focal amplifications of CCND1 and ERBB2
18   70/f 12 Negative < 8 Atypias Gain of 1q, 4p, 5, 8, 12p; losses of 1p, 4q, 6q, 11p, 14q, 17p
19   74/f 7 Negative 2 No No chromosomal changes
20   46/m 15 Patchy positive < 1 Atypias  
21 Esteban et al. [17] 26/f 2.6    No  
22 Sturm et al. (2019) (present case) 63/f 6.5 Focally positive 20–30 Yes TP53 and KIT (NM_000546.5: c.215C> G, TP53; NM_000222.2: c.1621A> C, KIT)