Table 1 Reported biliary adenofibromas of the liver (n = 22)
No. | Reference | Age/sex | Tumor size (cm) | p53 | Ki67 (%) | Evidence of malignant transformation | Mutations found |
|---|---|---|---|---|---|---|---|
1 | Tsui et al. [2] | 74/f | 7 | No | |||
2 | Parada et al. [5] | 49/f | 7 | No | |||
3 | Akin and Coskun [4] | Pulmonary metastasis | |||||
4 | Garduno-Lòpez et al. [6] | 68/m | 6 | No | |||
5 | Varnholt et al. [7] | 21/f | 16 | No | |||
6 | Gurrera et al. [8] | 79/m | 5.5 | No | |||
7 | Kai et al. [9] | 40/m | 7 | Negative | 5–10 | Atypias | |
8 | Nguyen et al. [10] | 53/f | 6.5 | Yes | |||
9 | Nakanuma et al. [11] | 69/f | 3.5 | Focally positive | 10–15 | Yes | |
10 | Jacobs et al. [12] | 57/f | 10 | Atypias | |||
11 | Thai et al. [13] | 77/m | 4.8 | Yes | |||
12 | Godambe et al. [14] | 71/f | 6.3 | 50% | 20–50 | Yes | |
13 | Thompson et al. [15] | 71/m | 14.5 | Yes | Nonsense mutation in p16 INK4a | ||
14 | Kaminsky et al. [3] | 37/f | 4.5 | Negative | 50 | Yes | |
15 | Arnason et al. [16] | 83/m | 7 | ||||
16 | 47/f | 16 | 6 | Atypias | Large region gains in chromosome 1q; loss of 1p, 2p, 3q, 6q, 8p, 11p, 12q, 14, 16q | ||
17 | 57/f | 10; 2.5; 1.7 | Positive | < 10 | Atypias | gain of 1q; loss of 11q, 22q, Xq; focal amplifications of CCND1 and ERBB2 | |
18 | 70/f | 12 | Negative | < 8 | Atypias | Gain of 1q, 4p, 5, 8, 12p; losses of 1p, 4q, 6q, 11p, 14q, 17p | |
19 | 74/f | 7 | Negative | 2 | No | No chromosomal changes | |
20 | 46/m | 15 | Patchy positive | < 1 | Atypias | ||
21 | Esteban et al. [17] | 26/f | 2.6 | No | |||
22 | Sturm et al. (2019) (present case) | 63/f | 6.5 | Focally positive | 20–30 | Yes | TP53 and KIT (NM_000546.5: c.215C> G, TP53; NM_000222.2: c.1621A> C, KIT) |