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Surgical Case Reports
Fig. 5 | Surgical Case Reports

Fig. 5

From: Occupational cholangiocarcinoma diagnosed 18 years after the end of exposure to 1,2-dichloropropane and dichloromethane at a printing company: a case report

Fig. 5

Immunological staining using primary antibodies against γH2AX (a–e), S100P (f–j), and PD-L1 (k–o). Positive expressions of γH2AX and S100P were detected in almost all portions of invasive carcinoma, BilIN, and IPNB in the large bile ducts. Although γH2AX expression was also detected within the non-neoplastic biliary epithelium, similar to BilIN, IPNB, and invasive carcinoma, S100P expression was absent or relatively weak in the non-neoplastic epithelium (a–j). PD-L1 expression was absent in the stromal cells in the tumor at segment 3 of Glisson’s sheath (l) and the non-neoplastic epithelium (o). Positive PD-L1 expression was partially detected in the tumor cells of the enlarged mass in the hepatoduodenal ligament (k), BilIN (m), and IPNB (n)

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