Bevacizumab is associated with delayed anastomotic leak after low anterior resection with preoperative radiotherapy for rectal cancer: a case report

Surgical Case Reports

Table 1 Clinical features of ten patients with delayed anastomotic leak associated with bevacizumab treatment

Report	Age/gender¹	Primary tumor	Preoperative radiation therapy	Previous history of anastomotic leak	Anastomotic complication	Interval between initial surgery and leak (months)	Duration of bevacizumab treatment	Interval between last bevacizumab dose and leak
Adenis et al. [9]	50/F	Rectum	Yes	Yes	Leak ileovaginal fistula	22	1 month (2 doses)	< 1 month
Ley et al. [7]	72/F	Rectum	Yes	No	Leak rectovaginal fistula	30	6 months	< 1 month
August et al. [6]	58/M	Rectum	Yes	Yes	Leak	26	6 weeks (3 doses)	Not described
August et al. [6]	74/F	Rectum	Yes	No	Leak	33	20 weeks	4 months
Bege et al. [8]	46/M	Rectum	Yes	Yes	Leak	52	Not described	1 week
Bege et al. [8]	54/M	Rectum	Yes	Yes	Leak	57	Not described	2 weeks
Bege et al. [8]	51/M	Rectum	Yes	No	Leak	21	Not described	2 weeks
Borzomati et al. [10]	68/M	Rectum	Yes	Yes	Leak	33	24 weeks	2 weeks
O’Hare et al. [11]	56/F	Rectum	Yes	No	Leak	17	6 weeks (3 doses)	1 month
Present patient	78/M	Rectum	Yes	No	Leak	60	3 years (26 doses)	1 month