Nontuberculous mycobacterial infection after lung transplantation: a report of four cases

Surgical Case Reports

Table 4 Details of very late onset reported cases

0	References		Age	Sex	Reason fot LuTx	LuTx	Time to onset	Symptoms	Chest X-ray findings	Culture	Pathogen	Drug for treatment	Outcome
1	1999	Malouf [3]	55	F	PAH	HL	8.9 years	Cough, sputum, dyspnea, fever	Normal	Sputum	MABSC	Ri + C + Ci	Alive
2			38	M	CHD	HL	4.3 years	Cough, sputum, dyspnea, fever	Bilateral apical infiltrate	BAL	M.avium	R + E + C + Ci	Alive
3			45	F	Empysema	SL	3.6 years	Cough, sputum, dyspnea, fever	Basal infiltrates	BAL	MAC	Ri + C + Ci	Alive
4			32	M	AATD	SL	3.6 years	Cough, dyspnea, fever	Apical and mid-zone infiltrates	Sputum	MAC	Ri + C + Ci	Dead
5			54	M	Empysema	SL	3.7 years	Cough, sputum, dyspnea, fever	Consolidation in midzone	BAL	M.avium	No treatment	Alive
6			48	M	AATD	SL	3.3 years	Cough, sputum, dyspnea, fever	Infiltrate in transpranted lung	Pleural fliud	M.asiaticum	R + E + P	Alive
7	2002	Fairhurst [5]	55	F	PAH	HL	9.0 years	Cough, sputum, dyspnea, fever	–	BAL	MABSC	Ri + C + Ci	Alive
8	2006	Chernenko [6]	40	F	Eisenmenger	HL	9.1 years	Fever, chills	–	Sputum	MABSC	R + C + Ci	Dead
9			48	M	COPD	SL	8.4 years	Fever, chills	–	BAL + sputum	MABSC	R + E + C	Dead
10			53	M	COPD	BL	8.5 years	Sputum	Normal	BAL + sputum	MABSC	R + E + Ci	Alive
11			39	M	CF	BL	9.3 years	Sputum	Nodules	Sputum	MABSC	Ri + C + Ci + E	Alive
12			42	F	LAM	BL	4.1 years	Sputum	Nodules	Sputum	MABSC	AMK + AZ + cefoxitin+Ci	Alive
13	2012	Knoll [8]	28	F	CF	BL	3.2 years	–	–	BAL	M.avium	–	Alive
14	2018	Our study	10	M	PAH	LDLT	6.3 years	None	Apical infiltrates	BAL	M.godnae	no treatment	Alive
15			35	F	BE	LDLT	6.8 years	Fever, sputum	Basal infiltrates	BAL	MABSC	TAZ/PIPC+AZM	Alive
16			41	F	LAM	SL	4.8 years	Sputum	Basal infiltrates	Sputum	MABSC	AZM + IPM + AMK	Alive

AATD α 1-antitrypsin deficiency, AMK amikacin, AZM azithromycin, BAL bronchoalveolar lavage, BE bronchiectasis, BL bilatetal lung, C Clarithromycin, CF cystic fibrosis, CHD congenital heart disease, Ci ciprofloxacin, COPD chronic obstructive pulmonary disease, E Ethambutol, HL heart-lung, IPM imipenem, LAM lymphangioleiomyomatosis, LDLT living donor lung transplantation, P Pyridoxal Phosphate Hydrate, PAH pulmonary arterial hypertension, R rifampicin, Ri Rifabutin, SL single lung, TAZ/PIPC Tazobactam / Piperacillin