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Table 1 Summarized data on published reports concerning ICC with sarcomatous change

From: Primary intrahepatic cholangiocarcinoma with sarcomatous stroma: case report and review of the literature

Author Year Age (years)/ Gender Tumor location Tumor size (cm) Plain CT Enhancement CT T1WI T2WI Treatment Carcinomatous component Sarcomatous component Distribution Transitional feature IHC of carcinomatous component IHC of sarcomatous component Preoperative diagnosis
Sasaki et al. [13] 1991 79/M Left lobe 8 ND ND ND ND None Adenosquamous carcinoma Spindle and pleomorphic cells ND ND Keratin+, EMA+, Vim+ ND
Haratake et al. [14] 1992 59/M Left lobe Fist-sized ND ND ND ND None Poorly adenocarcinoma Spindle cells Intermingled ND EMA+, CEA+, CK+ Vim+ Liver abscess
Nakajima et al. [15] 1993 84/F Hepatic hilum 3.5 ND ND ND ND None Moderately adenocarcinoma Spindle and pleomorphic cells Intermingled + Keratin+, EMA+ Keratin+, EMA+, CA19-9+ ND
43/F Right lobe 14 ND ND ND ND Right lobectomy Moderately adenocarcinoma Spindle cells Intermingled + Keratin+, EMA+ Keratin+, EMA+, Vim+ ND
73/F Left lobe 7 ND ND ND ND Anti-cancer chemotherapy Moderately adenocarcinoma Spindle and pleomorphic cells Intermingled + Keratin+, EMA+ None ND
37/M Left lobe 10 ND ND ND ND None Moderately adenocarcinoma Spindle and pleomorphic cells Intermingled + Keratin+, EMA+ Keratin+, EMA+, Vim+ ND
64/M Left lobe 7.5 ND ND ND ND TAE Poorly adenocarcinoma Spindle and pleomorphic cells Intermingled + Keratin+, EMA+ Keratin+, EMA+ ND
52/M Right lobe 7.5 ND ND ND ND TAE Poorly adenocarcinoma Spindle and pleomorphic cells Intermingled + Keratin+, EMA+ Keratin+, EMA+, CEA+ ND
69/M Left lobe 10 ND ND ND ND Left lobectomy Poorly adenocarcinoma Spindle cells Intermingled + Keratin+, EMA+ None ND
Imazu et al. [16] 1995 77/M Segment 2 6 Low density Ring enhancement Low intensity Low intensity Lateral segmentectomy Glandular formation Spindle cells Intermingled ND Keratin+, CEA+, Vim+, Keratin+, CEA+, Vim+, ICC
Honda et al. [17] 1996 61/F Right lobe Numerous variously sized ND ND ND ND None Moderately to poorly adenocarcinoma Rhabdoid cells Separated (intermingled at the border) + Keratin+ Keratin+, CEA-, Vim+ ICC with peritonitis carcinomatosa
Matsuo et al. [18] 1999 77/F Left lobe 7.7 Low density Ring enhancement Iso- to low intensity Heterogeneous high and low intensity Left lobectomy Moderately to poorly adenocarcinoma Spindle cells Intermingled + EMA+, CK+, CEA+ Vim+, Epithelial markers- Liver abscess
Itamoto et al. [19] 1999 70/M Segment 5/6 10.7 Low density Poor ND ND Right lobectomy Moderately adenocarcinoma Spindle cells Intermingled + CA19-9+, EMA+ Keratin+, Vim- Keratin+, EMA+, Vim-H Recurrent HCC
Shimada et al. [20] 2000 70/M Segment 5 3.4 ND ND ND ND Central bisegmentectomy Poorly adenocarcinoma Spindle cells Intermingled + EMA+, Keratin+, CEA+, Vim+ EMA+, Keratin+, Vim+ ND
55/M Segment 7/8 6.7 ND ND ND ND Partial hepatectomy Moderately to poorly adenocarcinoma Spindle and pleomorphic cells Intermingled + EMA+, Keratin+ EMA+, Keratin+, Vim+ ND
74/F Segment 8 4.0 ND ND ND ND Right lobectomy Poorly adenocarcinoma Spindle cells Intermingled + EMA+, Keratin+, CEA+, Vim+ EMA+, Keratin+, CEA+, Vim+ ND
64/F Segment 4 8.0 ND ND ND ND Left trisegmentectomy Moderately to poorly adenocarcinoma Spindle cells Intermingled + EMA+, Keratin+, CEA+, CA19-9+,AFP+, Vim+ EMA+, Keratin+, CEA+, CA19-9+, Vim+ ND
Kaibori et al. [21] 2003 69/F Lateral segment 20 Low density Ring enhancement ND ND Lateral segmentectomy Moderately adenocarcinoma Spindle and pleomorphic cells Intermingled + ND Vim+, EMA+, CK+ Leiomyosarcoma
Sato et al. [22] 2006 87/M Left lobe 4.0 ND ND ND ND None Moderately adenocarcinoma Round cells Intermingled ND CK7+, CK19+, CAM5.2+, CA19-9+ CK7+, CK19+, CAM5.2+, Vim+ ICC
Tsou et al. [23] 2008 69/F Left lobe 2.5 Low density Ring enhancement ND ND Segmentectomy Well to moderately adenocarcinoma Spindle and pleomorphic cells Intermingled ND ND CK7+, Vim+ ND
Malhotra et al. [24] 2010 60/F Segment 5 20 ND Heterogeneous mass ND ND Lateral segmentectomy Moderately adenocarcinoma Pleomorphic spindle cells Intermingled ND CAM5.2, EMA+, AE1/AE3+, CK7+, CK19+, CEA+ Vim+, Epithelial markers- ND
Inoue et al. [25] 2012 61/M Left lateral segment 20 Heterogeneous mass Ring enhancement ND ND Lateral segmentectomy Moderately adenocarcinoma ND ND + CK7+, CK19+ Vim+, Keratin-1+ GIST
Nakajima et al. [26] 2012 77/F Right lobe 14 Low density Heterogeneous enhancement Low intensity Iso- to high intensity Right hepatic trisegmentectomy and caudate lobectomy Moderately adenocarcinoma Spindle cells and chondrosarcomatous change Intermingled   AE1+ Vim+, Keratin- CCC or cystadenocarcinoma
Watanabe et al. [27] 2014 62/M Hepatic hilum 5.0 Low density Ring enhancement ND ND Extended right hemihepatectomy Moderately to poorly adenocarcinoma Spindle and pleomorphic cells Intermingled ND CK+ CK+, Vim+ ND
Kim et al. [28] 2015 67/F Left lateral segment 4.5 Low density Heterogeneous enhancement ND ND Left lobectomy Well to moderately adenocarcinoma Pleomorphic and spindle cells with osteoclast like giant cell Intermingled ND CK19+ Vim+ ICC
Boonsinsukh et al. [29] 2018 45/M Right lobe 7.0 Low density Mild delayed enhancement ND ND Right hepatectomy Moderately adenocarcinoma Spindle cells Intermingled ND Vim+, AE1/AE3+, CAM5.2+, CK7+ , CK19+ ND ICC
Our case 2018 60/M Caudate lobe 7.5 Low density Heterogeneous enhancement Low intensity Iso- to high intensity Left lobectomy and caudate lobectomy Moderately to poorly adenocarcinoma Spindle cells Separated (intermingled at the border)   CK7+, CK19+, EMA+ S-100+, aSMA+, CD 10+ ICC
  1. CK cytokeratin, CA19-9 carbohydrate antigen 19-9, CT computed tomography, EMA epithelial membrane antigen, ICC intrahepatic cholangiocarcinoma, HCC hepatocellular carcinoma, IHC immunohistochemical, SMA smooth muscle actin, Vim vimentin, ND not described