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Table 1 Perioperative coagulation management on administration of FVIII/VWF concentrates in patients with aVWS

From: Administration of plasma-derived coagulation factor VIII during the perioperative period of mastectomy for breast cancer with acquired von Willebrand syndrome

  Therapeutic goal VWF activity Loading dose Maintenance dose Number of doses a day
Minor surgery Day of surgery 50–100% 40–60 IU/kg 30–40 IU/kg 2
  2–7 days 30–50%   20–30 IU/kg 1–2
Major surgery Day of surgery to 3 days 100% 30–60 IU/kg 40 IU/kg 2–3
  4–7 days 50–100%   30–40 IU/kg 2
  8–14 days 30–50%   20–30 IU/kg 1–2
  1. IU international unit