Administration of plasma-derived coagulation factor VIII during the perioperative period of mastectomy for breast cancer with acquired von Willebrand syndrome

Surgical Case Reports

Table 1 Perioperative coagulation management on administration of FVIII/VWF concentrates in patients with aVWS

		Therapeutic goal VWF activity	Loading dose	Maintenance dose	Number of doses a day
Minor surgery	Day of surgery	50–100%	40–60 IU/kg	30–40 IU/kg	2
	2–7 days	30–50%		20–30 IU/kg	1–2
Major surgery	Day of surgery to 3 days	100%	30–60 IU/kg	40 IU/kg	2–3
	4–7 days	50–100%		30–40 IU/kg	2
	8–14 days	30–50%		20–30 IU/kg	1–2