Table 1 Summary of cases of neuroendocrine carcinomas arising in Barrett’s esophagus
No. | Author | Age (y) | Sex | Chief complaints | Reflux symptoms | Siewert classification | Tumor size (mm) | T | N | M | Stage | Tumor type | Chromogranin | Synaptophysin | Treatment | Postoperative survival |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | Slavin (1994) | 63 | F | Dysphagia and weight loss | (+) | Type 2 | 50 | 1 | 1 | 1 | IV | Pure NEC | (+) | (−) | Esophagogastrectomy | Died at 3 months |
2 | Saw (1997) | 43 | F | Epigastric pain | (+) | Type 1 | 25 | N.A. | N.A. | N.A. | N.A. | NEC with adenocarcinoma | (+) | (+) | Esophagectomy | Alive at 36 months |
3 | Saint Martin (1999) | 54 | F | Dysphagia | (+) | Type 2 | N.A. | N.A. | N.A. | N.A. | N.A. | Pure NEC | (−) | (+) | Esophagogastrectomy | N.A. |
4 | Chen (2000) | 64 | M | Dysphagia | (−) | Type 1 | 40 | N.A. | N.A. | N.A. | N.A. | Pure NEC | N.A. | N.A. | CRT | Alive at 14 months |
5 | Wilson (2000) | 51 | M | Epigastric discomfort and dysphagia | (+) | Type 2 | 40 | 1b | 0 | 0 | IA | NEC with adenocarcinoma | (−) | (+) | Esophagogastrectomy | N.A. |
6 | Gonzalez (2003) | 75 | M | Anorexia, weight loss, and dysphagia | (+) | Type 2 | 45 | 2 | 0 | 0 | IB | NEC with adenocarcinoma | (−) | (+) | Esophagogastrectomy | N.A. |
7 | Bibeau (2008) | 54 | M | Epigastric discomfort | (+) | Type 2 | 20 | 2 | 0 | 0 | IB | NEC with adenocarcinoma | (+) | (+) | CRT and esophagectomy | Alive at 72 months |
8 | Markogiannakis (2008) | 62 | M | Epigastric pain, epigastric fullness, dysphagia, anorexia, and weight loss | (+) | Type 2 | 25 | 2 | 1 | 0 | IIB | Pure NEC | (+) | (−) | CRT and esophagogastrectomy | N.A. |
9 | Current report | 71 | M | No symptoms | (−) | Type 2 | 10 | 1b | 0 | 0 | IA | NEC with adenocarcinoma | (+) | (+) | Proximal gastrectomy | Alive at 36 months |