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Table 1 Summary of cases of neuroendocrine carcinomas arising in Barrett’s esophagus

From: A neuroendocrine carcinoma with a well-differentiated adenocarcinoma component arising in Barrett’s esophagus: a case report and literature review

No. Author Age (y) Sex Chief complaints Reflux symptoms Siewert classification Tumor size (mm) T N M Stage Tumor type Chromogranin Synaptophysin Treatment Postoperative survival
1 Slavin (1994) 63 F Dysphagia and weight loss (+) Type 2 50 1 1 1 IV Pure NEC (+) (−) Esophagogastrectomy Died at 3 months
2 Saw (1997) 43 F Epigastric pain (+) Type 1 25 N.A. N.A. N.A. N.A. NEC with adenocarcinoma (+) (+) Esophagectomy Alive at 36 months
3 Saint Martin (1999) 54 F Dysphagia (+) Type 2 N.A. N.A. N.A. N.A. N.A. Pure NEC (−) (+) Esophagogastrectomy N.A.
4 Chen (2000) 64 M Dysphagia (−) Type 1 40 N.A. N.A. N.A. N.A. Pure NEC N.A. N.A. CRT Alive at 14 months
5 Wilson (2000) 51 M Epigastric discomfort and dysphagia (+) Type 2 40 1b 0 0 IA NEC with adenocarcinoma (−) (+) Esophagogastrectomy N.A.
6 Gonzalez (2003) 75 M Anorexia, weight loss, and dysphagia (+) Type 2 45 2 0 0 IB NEC with adenocarcinoma (−) (+) Esophagogastrectomy N.A.
7 Bibeau (2008) 54 M Epigastric discomfort (+) Type 2 20 2 0 0 IB NEC with adenocarcinoma (+) (+) CRT and esophagectomy Alive at 72 months
8 Markogiannakis (2008) 62 M Epigastric pain, epigastric fullness, dysphagia, anorexia, and weight loss (+) Type 2 25 2 1 0 IIB Pure NEC (+) (−) CRT and esophagogastrectomy N.A.
9 Current report 71 M No symptoms (−) Type 2 10 1b 0 0 IA NEC with adenocarcinoma (+) (+) Proximal gastrectomy Alive at 36 months
  1. N.A. not available, NEC neuroendocrine carcinoma, CRT chemoradiotherapy