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Surgical Case Reports
Fig. 3 | Surgical Case Reports

Fig. 3

From: Paget’s disease derived in situ from reserve cell hyperplasia, squamous metaplasia, and squamous cell carcinoma of the esophagogastric junction: a case report

Fig. 3

Microscopic findings. a Hematoxylin and eosin staining of a tumor section, showing neoplastic cells (Paget cells) with a large nucleus and a pale-staining cytoplasm in the lower part of the esophageal epithelium. b, c Reserve cell hyperplasia (b) and squamous metaplasia (c) in the esophagogastric junction. d A squamous cell carcinoma component identified in the same area. e–g Immunohistochemical staining of Paget cells. CK5 expression was not detected in Paget cells (e). CK7 (f) and p53 expression (g) were observed

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