Table 2 Review of P-EMC cases: Cases and clinicopathological features
From: Epithelial-myoepithelial carcinoma of the lung: a case report
Year | Author | Predominant component | High mitotic rate/necrosis/Ly,V,N invasion | Ki-67 | p53 | Metastasis | F/U (months) |
|---|---|---|---|---|---|---|---|
1994 | Moran CA et al. [3] | G | −/−/− | NA | NA | Free | FOD(72) |
M | (2–3/10HPF)/+/− | NA | NA | Free | FOD(48) | ||
M | −/−/− | NA | NA | Free | NA | ||
M | (2–3/10HPF)/+/− | NA | NA | Free | Died of surgery(0) | ||
G | −/−/− | NA | NA | Free | NA | ||
M | (5–10/10HPF)/+/− | NA | NA | Free | Recurred LN mets after 2 years | ||
M | (5–10/10HPF)/+/+ | NA | NA | Free | Recurred after 3 years in trachea After CRTx, mets to multiple organs Died of P-EMC. | ||
M | (2–3/10HPF)/−/− | NA | NA | Free | NA | ||
1994 | Nistal et al. [4] | G | Scanty/NA/− | NA | NA | Free | FOD(24) |
1995 | Tsuji et al. [5] | M | Rarely/+/− | NA | NA | Free | FOD(36), died of unrelated disease. |
1997 | Wilson RW et al. [6] | G | −/−/− | NA | NA | Free | FOD(7) |
1998 | Shanks et al. [7] | G | (1/20HPF)/−/− | NA | NA | Free | NA |
1998 | Ryska et al. [8] | G | NA/NA/NA | NA | NA | Free | FOD(13) |
2001 | Fulford LG et al. [9] | G | (1/20HPF)/−/− | 2–10% | NA | Free | FOD(8) |
G | (1/20HPF)/−/− | 1–2% | NA | Free | FOD(60) | ||
M | −/−/− | < 1% | NA | Free | FOD(96) | ||
M | (1/20HPF)/+/− | 1–2% | NA | Free | FOD(84) | ||
2001 | Pelosi et al. [2] | NA | −/−/− | G)1.5%, M)12% | − | Free | FOD(6) |
2003 | Doganay et al. [10] | NA | Few/+/− | G)1%, M)8% | − | Free | FOD(34) |
2004 | Ru et al. [11] | G | A few/NA/− | < 5~20% | + | Free | FOD(8) |
2007 | Chao et al. [12] | NA | −/NA/NA | 2.8 | + | Free | FOD(6) |
2007 | Musulimani et al. [13] | NA | −/NA/NA | NA | NA | Free | recurred bilateral lung lesions, Tumor bearing(48) |
2007 | Chang et al. [14] | G | Rare/NA/NA | < 5% | NA | NA | FOD(31) |
G | Rare/NA/NA | < 5% | NA | NA | FOD(14) | ||
G | Rare/NA/NA | < 5% | NA | NA | FOD(13) | ||
G | Rare/NA/NA | < 5% | NA | NA | FOD(78) | ||
G | Rare/NA/NA | < 5% | NA | Bilateral lung nodules. | No recurrence(5) not changed in appearance on a follow-up CT | ||
2009 | Nguen et al. [15] | NA | Rare/NA/ 1 case: Ly(+), V(+), N(+) | NA | NA | 1/5 case: infiltrated peribronchial tissue and LN metastasis. | FOD(4) |
NA | NA | NA | FOD(12) | ||||
NA | NA | NA | NA | ||||
NA | NA | NA | FOD(12) | ||||
NA | NA | NA | FOD(4) | ||||
2009 | Rosenfeld et al. [16] | NA | Rare~few/−/NA | NA | NA | The biphasic neoplastic cells replaced part of a lymph node. | FOD(12) |
2011 | Nishihara et al. [17] | NA | (−/−/NA)(biopsy) | (10%)(biopsy) | NA | NA/skull metastasis | NA |
2011 | Munoz et al. [18] | G | −/−/− | NA | NA | Free | NA |
2011 | Kang et al. [19] | NA | NA | NA | NA | Free | 1/2 case: recurrence; ipsilateral lung, pneumonectomy |
2012 | Arif et al. [20] | G | (2–3/10HPF)/−/NA | 2–3% | NA | Free | FOD(9) |
2013 | Zhu et al. [21] | NA | NA/NA/NA | NA | NA | Free | 5-year OS, 100%, 1 case: mets to bone within 3 years, Others: FOD(~60) |
2013 | Konoglou et al. [22] | NA | NA/NA/NA | Particularly low | NA | − | FOD(24) |
2014 | Cho et al. [23] | NA | A few/NA/NA | NA | NA | Free | FOD(16) |
2014 | Song et al. [24] | M(> 95%) | −/−/NA | NA | NA | Free | Recurrence(33), Complete pneumonectomy, mets to chest wall(37), Died of P-EMC(117) |
M(30%) | −/+/NA | NA | NA | Free | FOD(75) | ||
M(60%) | −/−/NA | NA | NA | Free | FOD(33) | ||
M(70%) | −/−/NA | NA | NA | Free | FOD(1) | ||
M(40%) | −/−/NA | NA | NA | Free | FOD(10) | ||
2015 | Cha et al. [25] | M | NA/+/− | G) < 1% M) 40% | NA | Hilar LN+subcarinal LN+ | Adj Chemo |
2015 | Tajima et al. [26] | M(70–90%) | A few/−/V(+) | G)1.6%, M)2.8–14.2% | a few + | Free | FOD(4) |
2016 | Shen et al. [27] | NA | NA/NA/NA | NA | NA | Free | FOD(8) |
Current case | G | Rare/+/− | < 5% | NA | Free | FOD(36) | |