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Table 1 Previously reported cases of esophageal or esophagogastric MANEC

From: A case of mixed adenoneuroendocrine carcinoma (MANEC) arising in Barrett’s esophagus: literature and review

Case

Age

Sex

Location

Treatment

Tumor size (cm)

Tumor depth

LN metastasis

Adjuvant chemotherapy

Recurrence

Prognosis

Author, year

1

64

Male

Ut

Surgery

1.7

T1

N0

None

None

Alive (16 months)

Kitajima, 2013

2

63

Male

EGJ

Surgery

9.7

T3

N2

NAC (CDDP + CPT-11), adjuvant (S-1 + CDDP)

None

Alive (24 months)

Nakai, 2013

3

68

Male

EGJ

ESD

ND

T1

ND

ND

ND

ND

Veits, 2013

4

68

Male

Lt

Surgery

9.5

T4

Positive

ND

ND

ND

Kadhim, 2016

5

57

Male

EGJ

Surgery

ND

T3

N3

Chemoradiation (details ND)

None

Alive (8 months)

Juanmartinena, 2017

6

64

Female

Mt

Surgery

4.0

T2

N1

Platinum and VP-16

Supraclavicular lymph nodes and liver (4 months)

Dead (8 months)

Yuan, 2017

7

62

Male

Mt

Surgery

6.0

T2

N2

Platinum and VP-16

Pleural effusion (2 months)

Dead (19 months)

Yuan, 2017

Our case

70

Male

EGJ

Surgery

2.5

T1

N0

None

None

Alive (4 months)

 
  1. Mt middle esophagus, EGJ esophagogastric junction, Lt lower esophagus, Ut upper esophagus, ESD endoscopic submucosal dissection, NAC neoadjuvant chemotherapy, CDDP cisplatin, VP-16 etoposide, ND not described