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Table 3 Clinical features of 33 Carney Complex patients reported in Japan

From: Carney complex: a case with thyroid follicular adenoma without a PRKAR1A mutation

Clinical features

No. of patients

%

Age

mean, 30.3 years (range; 3-73 years)

 

 with PRKAR1A mutation

mean, 26.6±20.2 (n=7)

 without PRKAR1A mutation

mean, 64.3±11.7 (n=3)

 not available

mean, 27.0±15.5 (n=23)

Gender

 Male

7

21

 Female

26

79

Family history

 yes

13

39

 no

20

61

Chief complaints

 subcutaneous or beast tumor

9

27

 pigment deposition of the skin

8

24

 Cushing sign

11

33

 others

1

3

 no symptom

4

12

Clinical manifestations

 spotty skin pigmentation

16

49

 cardiac myxoma

14

42

 cutaneous myxoma

13

39

 primary pigmented nodular adrenocortical disease (PPNAD)

17

52

 large-cell calcifying Sertoli cell tumor or steroid-type tumor or both

1

3

 mammary myxomatosis or fibroadenoma

7

21

 pituitary adenoma (acromegaly)

13

39

 thyroid tumors

5

15

 osteochondromyxoma

0

0

 psammomatous melanotic schwannoma

0

0

 blue nevus

0

0

Operation history

 none

6

18

 once

15

46

 twice

6

18

 more than three times

6

18