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Table 3 Clinical features of 33 Carney Complex patients reported in Japan

From: Carney complex: a case with thyroid follicular adenoma without a PRKAR1A mutation

Clinical features No. of patients %
Age mean, 30.3 years (range; 3-73 years)  
 with PRKAR1A mutation mean, 26.6±20.2 (n=7)
 without PRKAR1A mutation mean, 64.3±11.7 (n=3)
 not available mean, 27.0±15.5 (n=23)
Gender
 Male 7 21
 Female 26 79
Family history
 yes 13 39
 no 20 61
Chief complaints
 subcutaneous or beast tumor 9 27
 pigment deposition of the skin 8 24
 Cushing sign 11 33
 others 1 3
 no symptom 4 12
Clinical manifestations
 spotty skin pigmentation 16 49
 cardiac myxoma 14 42
 cutaneous myxoma 13 39
 primary pigmented nodular adrenocortical disease (PPNAD) 17 52
 large-cell calcifying Sertoli cell tumor or steroid-type tumor or both 1 3
 mammary myxomatosis or fibroadenoma 7 21
 pituitary adenoma (acromegaly) 13 39
 thyroid tumors 5 15
 osteochondromyxoma 0 0
 psammomatous melanotic schwannoma 0 0
 blue nevus 0 0
Operation history
 none 6 18
 once 15 46
 twice 6 18
 more than three times 6 18