From: Carney complex: a case with thyroid follicular adenoma without a PRKAR1A mutation
Clinical features | No. of patients | % |
---|---|---|
Age | mean, 30.3 years (range; 3-73 years) | |
with PRKAR1A mutation | mean, 26.6±20.2 (n=7) | |
without PRKAR1A mutation | mean, 64.3±11.7 (n=3) | |
not available | mean, 27.0±15.5 (n=23) | |
Gender | ||
Male | 7 | 21 |
Female | 26 | 79 |
Family history | ||
yes | 13 | 39 |
no | 20 | 61 |
Chief complaints | ||
subcutaneous or beast tumor | 9 | 27 |
pigment deposition of the skin | 8 | 24 |
Cushing sign | 11 | 33 |
others | 1 | 3 |
no symptom | 4 | 12 |
Clinical manifestations | ||
spotty skin pigmentation | 16 | 49 |
cardiac myxoma | 14 | 42 |
cutaneous myxoma | 13 | 39 |
primary pigmented nodular adrenocortical disease (PPNAD) | 17 | 52 |
large-cell calcifying Sertoli cell tumor or steroid-type tumor or both | 1 | 3 |
mammary myxomatosis or fibroadenoma | 7 | 21 |
pituitary adenoma (acromegaly) | 13 | 39 |
thyroid tumors | 5 | 15 |
osteochondromyxoma | 0 | 0 |
psammomatous melanotic schwannoma | 0 | 0 |
blue nevus | 0 | 0 |
Operation history | ||
none | 6 | 18 |
once | 15 | 46 |
twice | 6 | 18 |
more than three times | 6 | 18 |