From: Carney complex: a case with thyroid follicular adenoma without a PRKAR1A mutation
Carney [4])/1985 n=40 | Stratakis [3]/2001 n=338 | Correa [5]/2015 n=750 | |
---|---|---|---|
Gender | |||
Male | 40 | 43 | 37 |
Female | 60 | 57 | 63 |
Family history | 25 | 70 | 70 |
Clinical manifestations | |||
Spotty skin pigmentation | 65 | 77 | 70-80 |
Cardiac myxoma | 72 | 53 | 20-40 |
Cutaneous myxoma | 45 | 33 | 30-50 |
Primary pigmented nodular adrenocortical disease (PPNAD) | 45 | 26 | 25-60 |
Large-cell calcifying Sertoli cell tumor or steroid-type tumor or both | 56 | 33 | 41 |
Mammary myxomatosis or fibroadenoma | 42 | 3 | 20 |
Pituitary adenoma (acromegaly) | 10 | 10 | 75 |
Thyroid tumors | 0 | 5 | 75 |
Osteochondromyxoma | 0 | 2 | rare |
Psammomatous melanotic schwannoma | 5 | 10 | 10 |
Blue nevus | 0 | 0 | 75 |
Mutation of PRKAR1A gene | NA | 41 | 70-80 |