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Table 2 Clinical manifestations of Carney Complex in previous reports

From: Carney complex: a case with thyroid follicular adenoma without a PRKAR1A mutation

 

Carney [4])/1985

n=40

Stratakis [3]/2001

n=338

Correa [5]/2015

n=750

Gender

 Male

40

43

37

 Female

60

57

63

Family history

25

70

70

Clinical manifestations

 Spotty skin pigmentation

65

77

70-80

 Cardiac myxoma

72

53

20-40

 Cutaneous myxoma

45

33

30-50

 Primary pigmented nodular adrenocortical disease (PPNAD)

45

26

25-60

 Large-cell calcifying Sertoli cell tumor or steroid-type tumor or both

56

33

41

 Mammary myxomatosis or fibroadenoma

42

3

20

 Pituitary adenoma (acromegaly)

10

10

75

 Thyroid tumors

0

5

75

 Osteochondromyxoma

0

2

rare

 Psammomatous melanotic schwannoma

5

10

10

 Blue nevus

0

0

75

Mutation of PRKAR1A gene

NA

41

70-80

  1. The table gives the percentage of CNC patients
  2. NA not available